The Best Time to Take Omega-3s for Maximum Absorption

Omega-3 fatty acids are an important part of the human diet, and they play a crucial role in many bodily systems, including heart, brain and joint function. These fats—found in a variety of foods like fish, flaxseeds and walnuts—are known for their anti-inflammatory properties and potential to reduce the risk of chronic diseases such as heart disease and even arthritis. Despite the presence of omega-3s in foods, supplementation may be necessary for some people, as omega-3 deficiency has been associated with depression, reduced ability to learn and higher risk of certain types of cancer. If you’re curious about whether a supplement is right for you, talk to a health care professional or registered dietitian. 

If you choose to supplement, it’s important to get the most out of your omega-3 supplement by prioritizing bioavailability. In this article, we delve into advice from registered dietitians on the best time to take omega-3s as well as other factors to consider in order to optimize absorption.

Deciding When to Take Your Omega-3 Supplement

Morning vs. Evening

Keelin Murphy, M.S., RD points out, “There needs to be more research done to give timing recommendations on omega-3 supplements. Mostly because measuring bioavailability is difficult.” She goes on to add, “One study observed better heart-health outcomes when supplementing at dinner, and worse health outcomes when supplementing at breakfast, attributing these results to circadian rhythm and stomach acid oxidation when consumed on an empty stomach”. 

However, Jaime Bachtell-Shelbert, RD brings up an interesting point: “For those who experience reflux and the unwanted fish taste after taking an omega-3s, I recommend a split dose by taking half a dose before breakfast and the other half before dinner.”

Timing Around Meals

Probably most importantly of all, the presence of fat in the digestive system aids in the digestion and absorption of these essential fatty acids. Because omega-3s are fat-soluble, it’s recommended to consume them with a fat-containing meal to enhance their bioavailability.  As Bachtell-Shelbert explains, “It is recommended to take omega-3 supplements immediately before a meal that includes healthy fats. Doing so avoids floating oil in the stomach and promotes mixing with the meal for better digestion.” 

Murphy elaborates, ”Absorption of omega-3s is best when eaten in conjunction with a meal because our body produces the enzymes that break down fat [found in omega-3 supplements]."

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Factors to Consider

Type of Omega-3s

There are three main types of omega-3 fatty acids: EPA, DHA and ALA. EPA and DHA, which are often found in fish oil and algae oil, are typically easier for the body to utilize.

ALA, often found in plant-based sources such as flaxseed, walnuts and chia seeds, needs to be converted into EPA and DHA in the body before it can be used. However, this conversion is fairly inefficient, with only a small amount of ALA turning into EPA and DHA. Because of this, it’s recommended to seek out EPA and DHA in omega-3 supplements if you don’t avoid animal products. 

Supplement Sourcing

As you shop for omega-3 supplements, you’ll notice that sources of these essential fatty acids vary. Research shows that absorption varies depending on the source, so it’s key to keep this top of mind when purchasing. Below are three of the most common omega-3 supplement sources.

• Fish Oil: While fish oil is rich in EPA and DHA, it’s recommended to choose high-quality fish oil to avoid contaminants like heavy metals.
• Krill Oil: Krill oil also provides EPA and DHA but, as Murphy notes, “Krill oil has been shown to be more bioavailable than fish oil.” Additionally, krill oil contains the powerful antioxidant astaxanthin, which has been shown to help reduce oxidative stress.
• Algae Oil: Algae oil, on the other hand, is primarily composed of ALA, with some varieties fortified with EPA. These options are plant-based, making them a good choice for those following a vegetarian or vegan diet. 

Whenever possible, prioritize supplements that are independently verified for safety and label accuracy. 

Your Activity Level

Physical activity level is an important factor to consider when determining omega-3 supplementation needs, as it directly influences the body's demand for this essential fatty acid. For athletes, the anti-inflammatory properties of omega-3s can be particularly beneficial. Murphy notes, “Supplementation with omega-3s has been shown to increase performance, enhance recovery, reduce muscle soreness and lower risk of injury." 

Conversely, less-active individuals may have different omega-3 requirements. However, Murphy adds, “I recommend all of my athletes and most of my non-athlete clients to take fish oil, or some form of omega-3 fatty acid supplement” as most Americans don’t get enough through their typical diets. While anyone can benefit from the cardiovascular and  anti-inflammatory effects, less-active individuals may not require as many omega-3s as those with more active lifestyles. 

Tips for Enhancing Absorption of an Omega-3 Supplement

Take with Food

Research is scarce on what type of food is best to take with omega-3 supplements. However, it is recommended that you take your supplement with food, or around the same time as a meal, and not on an empty stomach.

Stay Consistent

These fatty acids work best when they build up to sufficient levels in the body over time. Regular consumption of these supplements helps to ensure steady levels of omega-3s within the body. Missing doses or taking them more sporadically might reduce their effectiveness and hinder their long-term benefits.

Check for Freshness

Murphy adds, “It’s also important to consider that fish oil and other supplemental sources of omega-3s can go rancid after time. I recommend purchasing new supplements every three to four months to ensure optimal absorption.”

Freshness is crucial because these fatty acids are prone to oxidation, which can reduce their beneficial properties. Oxidized omega-3s can even potentially produce harmful free radicals. Opt for a smaller size bottle if you’re worried about them going bad, and consider storing them in the refrigerator to extend their shelf life. 

Our Expert Take

To maximize the benefits of omega-3 supplements, understanding optimal timing and staying consistent are key. Omega-3s play a vital role in many body systems, and their effectiveness can be influenced by how and when they are taken. Ensuring that supplements are consumed with meals containing healthy fats can help enhance absorption, and regular intake helps maintain adequate levels in the body for long-term benefits. Additionally, prioritizing freshness and avoiding high-fiber meals can further help you utilize these essential fatty acids. Always talk to a health care professional or registered dietitian for personalized advice before trying something new..