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Sun, Oct 125:00 pm UTCLucas Oil Stadium
Track OnCBS Sports
Arizona
Cardinals
ARI
Last 5 ATS
W/L1-5
ATS4-3
O/U4-3-0
FINAL SCORE
27
-
31
Indianapolis
Colts
IND
Last 5 ATS
W/L5-1
ATS5-2
O/U4-3-0
SPREAD
MONEYLINE
OVER/UNDER
Last 5 ATS
1-5
Win /Loss
5-1
4-3
Spread
5-2
4-3-0
Over / Under
4-3-0
SPREAD
MONEYLINE
OVER/UNDER

Simulation Picks

SPREAD
ARI @ IND
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Maximize Your Odds of Winning with SportsLine Model and Our Top-Rated Picks

MONEYLINE
ARI @ IND
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OVER / UNDER
ARI @ IND
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33%
PUBLIC
67%
MONEY
7%
PUBLIC
93%
MONEY
Over46%
PUBLIC
Under54%
Over
MONEY
Under

Understanding Public and Money

Think of 'Public' as the percentage of people betting on each side and 'Money' as how much money is being bet. When there's a big difference between the 'Public' and 'Money' data, it usually means that the more serious bettors (referred to as 'Sharp Money') are favoring a particular side.

Expert Picks

Avatar
ReceptionsMichael Pittman Over 4.5 Total Receptions -140
LOSS
Unit1.0
+178
40-32 in Last 72 NFL Player Props Picks
Prop's Analysis:

FanDuel. Michael Pittman cleared this line in four of five games, with the only miss being four catches when he was matched up with Patrick Surtain. He’ll face off against a much softer secondary today - the Cardinals have allowed the fifth most receiver catches per game. And with Arizona missing both Kyler Murray and James Conner, I don’t see their offense sustaining long drives today.

Pick Made: Oct 12, 4:33 pm UTC on FanDuel
SpreadIndianapolis -9 -110
LOSS
Unit1.0
+721
14-6 in Last 20 NFL ATS Picks
+386
5-1 in Last 6 ARI ATS Picks
Bruce's Analysis:

Had we been a bit more clairvoyant here we might have been able to get Indy -6.5 instead of -9, as the spread has moved up with news of Kyler Murray likely missing action for the Cards. Ex-Colt (and ex-lots of others) Jacoby Brissett will be summoned from the bullpen in relief. Arizona seems snakebit, however, the first team since the merger to lose three consecutive games on last-second field goals. Will they come close again on Sunday? Maybe not, as the situation seems to be fraying, and the Colts have developed a real knockout punch this season, with a win margin of better than 20 ppg. As that's the case, even this enhanced number won't dissuade our interest. Play Colts

Pick Made: Oct 12, 6:49 am UTC on BetMGM
Avatar
Receiving YardsMarvin Harrison Jr. Over 48.5 Total Receiving Yards -115
LOSS
Unit1.0
+2418.5
43-24 in Last 67 NFL Player Props Picks
Daniel's Analysis:

I’m right in line with Sia Nejad again (we cashed on Tet McMillan last week) for another receiving yards prop. One of the bigger storylines you’ll see around this game is Marvin Harrison Jr’s first game in Indianapolis, where his father spent his legendary hall of fame career. Harrison Jr. soared over this line in each of the last 2 weeks, and has recorded a 30+ yard grab in 3/5 games. The Cardinals will start backup QB Jacoby Brissett, who is a capable veteran that can still get Harrison Jr. the ball. Arizona are +9.5 underdogs, and will likely be playing from behind and forced to go pass-heavy. These factors make Harrison Jr. worth a play this week.

Pick Made: Oct 12, 4:31 am UTC on BetMGM
Avatar
Receiving YardsMarvin Harrison Jr. Over 48.5 Total Receiving Yards -115
LOSS
Unit1.0
Sia's Analysis:

Too much talent and too good of an expected game script to have a receiving line south of 50 yards. Harrison has surpassed this line in each of his last two games. His targets per game are lower than I'd like, but a lot of that has been game script related. In trailing game scripts (Seattle) he was peppered with 10 targerts. I expect a trailing game script here against an average secondary. If you're narrative shopping, this is where Dad played and "Junior" has already been asked about that and embraced it. Note that if Jacoby Brissett starts I do not consider that a downgragde as it relates to this prop.

Pick Made: Oct 10, 4:09 pm UTC on BetMGM

Team Injuries

Arizona Cardinals
Monday, Oct 20, 2025
Avatar
QB
Kyler Murray
FootQuestionable
Avatar
RB
Emari Demercado
AnkleQuestionable
Avatar
SAF
Kitan Crawford
AnkleQuestionable
Indianapolis Colts
Monday, Oct 20, 2025
Avatar
DE
Samson Ebukam
Knee - MCLQuestionable
Avatar
WR
Ashton Dulin
ChestQuestionable
Avatar
RB
Tyler Goodson
GroinQuestionable
Avatar
WR
Josh Downs
ConcussionQuestionable
Sunday, Oct 19, 2025
Avatar
DE
Tyquan Lewis
GroinQuestionable
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