TFIID is a transcription factor complex that is required for RNAPII-mediated transcription of protein-coding genes and some small nuclear RNAs (reviewed in 4). The complex is composed of Spt15p (TATA binding protein; TBP) and 14 TBP-associated factors (TAFs): Taf1p, Taf2p, Taf3p, Taf4p, Taf5p, Taf6p, Taf7p, Taf8p, Taf9p, Taf10p, Taf11p, Taf12p, Taf13p, Taf14p (7, 10). The TFIID complex is required for basal transcription, but some individual subunits regulate the activated transcription of a subset of genes (13, 16, 17, 18, 19).Recognition of promoter DNA by the TFIID complex is required for the formation of the preinitiation complex (PIC) during transcription initiation (3, 6). The interaction between the TFIID complex and the promoter is stabilized by TFIIA (6, 11). The recruitment of TFIID to promoters is dependent on an upstream activating sequence in the promoter region (14). A subset of the TAFs (Taf5p, Taf6p, Taf9p, Taf10p, and Taf12p) are subunits of both TFIID and the the Spt-Ada-Gcn5-acetyltransferase (SAGA) transcriptional regulatory complex, which functions in nucleosomal histone acetylation and chromatin-associated transcriptional activation or repression (5, 8, 9). The results of genome-wide studies indicate that TFIID functions primarily at the TATA-less promoters of stress-repressed housekeeping genes, representing about 90% of the yeast genome, while SAGA predominates at highly-regulated, stress-responsive TATA box-containing genes, representing about 10% of the genome (12, 15).", "date_edited": "2009-10-02"}, "literature_overview": {"primary_count": 22, "additional_count": 38, "review_count": 30, "go_count": 5, "phenotype_count": 2, "disease_count": 0, "interaction_count": 51, "regulation_count": 4, "ptm_count": 9, "funComplement_count": 0, "htp_count": 8, "total_count": 141}, "disease_overview": {"manual_disease_terms": [], "htp_disease_terms": [], "computational_annotation_count": 0, "date_last_reviewed": null}, "ecnumbers": [], "URS_ID": null, "main_strain": "S288C", "genetic_position": 31.0, "regulation_overview": {"regulator_count": 3, "target_count": 0}, "reference_mapping": {"556641": 1, "549611": 2, "550252": 3, "593632": 4, "622591": 5, "470615": 6, "560352": 7, "555555": 8, "542570": 9, "536779": 10, "608643": 11, "545213": 12, "585367": 13, "554485": 14, "467934": 15, "616059": 16, "553618": 17, "609871": 18, "601509": 19, "627302": 20}, "history": [{"category": "Name", "history_type": "LSP", "note": "Name: TAF150", "date_created": "2010-02-16", "references": []}, {"category": "Name", "history_type": "LSP", "note": "Name: TAF2", "date_created": "2000-05-19", "references": [{"id": 556641, "display_name": "Tora L (2002)", "citation": "Tora L (2002) A unified nomenclature for TATA box binding protein (TBP)-associated factors (TAFs) involved in RNA polymerase II transcription. Genes Dev 16(6):673-5", "pubmed_id": 11963920, "link": "/reference/S000071622", "year": 2002, "urls": [{"display_name": "DOI full text", "link": "http://dx.doi.org/10.1101/gad.976402"}, {"display_name": "PubMed", "link": "http://www.ncbi.nlm.nih.gov/pubmed/11963920"}]}]}, {"category": "Name", "history_type": "LSP", "note": "Name: TafII150", "date_created": "2010-02-16", "references": []}, {"category": "Name", "history_type": "LSP", "note": "Name: TSM1", "date_created": "2010-02-16", "references": [{"id": 627302, "display_name": "Ray BL, et al. (1991)", "citation": "Ray BL, et al. (1991) The TSM1 gene of Saccharomyces cerevisiae overlaps the MAT locus. Curr Genet 20(1-2):25-31", "pubmed_id": 1840512, "link": "/reference/S000046664", "year": 1991, "urls": [{"display_name": "DOI full text", "link": "http://dx.doi.org/10.1007/BF00312761"}, {"display_name": "PubMed", "link": "http://www.ncbi.nlm.nih.gov/pubmed/1840512"}]}]}, {"category": "Nomenclature history", "history_type": "LSP", "note": "Nomenclature history: The names of Saccharomyces cerevisiae TBP-associated factor (TAF) genes have been changed to reflect guidelines recently enodorsed by the yeast community and published in Genes and Development. An explanation of the changes and a table with old and new gene names for S. cerevisiae, H. sapiens, D. melanogaster, C. elegans, and S. pombe may be found in the paper.", "date_created": "2002-03-25", "references": [{"id": 556641, "display_name": "Tora L (2002)", "citation": "Tora L (2002) A unified nomenclature for TATA box binding protein (TBP)-associated factors (TAFs) involved in RNA polymerase II transcription. Genes Dev 16(6):673-5", "pubmed_id": 11963920, "link": "/reference/S000071622", "year": 2002, "urls": [{"display_name": "DOI full text", "link": "http://dx.doi.org/10.1101/gad.976402"}, {"display_name": "PubMed", "link": "http://www.ncbi.nlm.nih.gov/pubmed/11963920"}]}]}, {"category": "Mapping", "history_type": "SEQUENCE", "note": "Mapping: Edition 14: TSM1 is also called TAF150", "date_created": "1997-10-20", "references": [{"id": 587084, "display_name": "Cherry JM, et al. (1997)", "citation": "Cherry JM, et al. (1997) Genetic and physical maps of Saccharomyces cerevisiae. Nature 387(6632 Suppl):67-73", "pubmed_id": 9169866, "link": "/reference/S000060841", "year": 1997, "urls": [{"display_name": "PMC full text", "link": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057085/"}, {"display_name": "PubMed", "link": "http://www.ncbi.nlm.nih.gov/pubmed/9169866"}]}]}, {"category": "Sequence change", "history_type": "SEQUENCE", "note": "Sequence change: The systematic sequence was updated in the region between ORFs YCR042C and YCR043C. Note that coordinates listed below are chromosomal coordinates.\r\n
Interaction annotations are curated by BioGRID and
include physical or genetic interactions
observed between at least two genes. An interaction annotation is composed of the
interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type
(e.g., manual or high-throughput), and a reference. Experimental details, phenotype,
modification, and multiple mutant information are included when available.
Source: All physical and genetic interaction annotations listed in SGD are curated by BioGRID.
An interaction is defined as an experimentally observed physical or genetic interaction
between two genes. There may be more than one row listed for the same interactor if the
interaction between it and the given gene was observed in separate studies. All
interactions
listed in SGD are curated by BioGRID.
Increase the total number of rows showing on this page by using the pull-down located below the table, or use the
page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column
header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small
"i" buttons located within a cell for an annotation to view further details about experiment type and any other
genes involved in the interaction.
An interaction is defined as an experimentally observed physical or genetic interaction
between two genes. There may be more than one row listed for the same interactor if the
interaction between it and the given gene was observed in separate studies. All
interactions
listed in SGD are curated by BioGRID.
Increase the total number of rows showing on this page by using the pull-down located below the table, or use the
page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column
header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small
"i" buttons located within a cell for an annotation to view further details about experiment type and any other
genes involved in the interaction.
This diagram displays physical (purple lines) and genetic (green lines) interactions between
the
given gene (yellow circle) and its interactors (gray circles) based on the number of
experiments
supporting each interaction (adjustable using the slider at the bottom). Interactions
between the
interactors for a given gene are also shown.
Click on a gene to go to its specific page within SGD; drag any of the gene objects around within the visualization
for easier viewing; filter by interaction type (genetic or physical) using the radio buttons;
click “Reset” to automatically redraw the diagram; filter the number of interactors displayed by
adjusting the number of experiments supporting a gene's interaction with the given gene by clicking anywhere on the
slider bar or dragging the tab to the desired filter number.
BioGRID |
CYC2008 |
DIP |
GeneMANIA |
IMP |
InterologFinder |
ModelArchive |
TheCellMap
\r\nOld: 204327 TTTATTGAATTAAATAAGACTTGATTTTGTAGCACGATATCCGCAAGAATGATTCACAAC 204386\r\n ||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||||\r\nNew: 205589 TTTATTGAATTAAATAAGACT-GATTTTGTAGCACGATATCCGCAAGAATGATTCACAAC 205647", "date_created": "2005-12-31", "references": []}], "complexes": [{"format_name": "CPX-1642", "display_name": "General transcription factor complex TFIID"}]}
TAF2 / YCR042C Interactions
Genetic Interactions
Genetic Interactions
Evidence ID
Analyze ID
Interactor
Interactor Systematic Name
Interactor
Interactor Systematic Name
Allele
Assay
Annotation
Action
Phenotype
SGA score
P-value
Source
Reference
Note
Physical Interactions
Physical Interactions
Evidence ID
Analyze ID
Interactor
Interactor Systematic Name
Interactor
Interactor Systematic Name
Assay
Annotation
Action
Modification
Source
Reference
Note
Interaction Network
Resources