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TFIID is a transcription factor complex that is required for RNAPII-mediated transcription of protein-coding genes and some small nuclear RNAs (reviewed in 4). The complex is composed of Spt15p (TATA binding protein; TBP) and 14 TBP-associated factors (TAFs): Taf1p, Taf2p, Taf3p, Taf4p, Taf5p, Taf6p, Taf7p, Taf8p, Taf9p, Taf10p, Taf11p, Taf12p, Taf13p, Taf14p (7, 10). The TFIID complex is required for basal transcription, but some individual subunits regulate the activated transcription of a subset of genes (13, 16, 17, 18, 19).Recognition of promoter DNA by the TFIID complex is required for the formation of the preinitiation complex (PIC) during transcription initiation (3, 6). The interaction between the TFIID complex and the promoter is stabilized by TFIIA (6, 11). The recruitment of TFIID to promoters is dependent on an upstream activating sequence in the promoter region (14). A subset of the TAFs (Taf5p, Taf6p, Taf9p, Taf10p, and Taf12p) are subunits of both TFIID and the the Spt-Ada-Gcn5-acetyltransferase (SAGA) transcriptional regulatory complex, which functions in nucleosomal histone acetylation and chromatin-associated transcriptional activation or repression (5, 8, 9). The results of genome-wide studies indicate that TFIID functions primarily at the TATA-less promoters of stress-repressed housekeeping genes, representing about 90% of the yeast genome, while SAGA predominates at highly-regulated, stress-responsive TATA box-containing genes, representing about 10% of the genome (12, 15).", "date_edited": "2009-10-02"}, "literature_overview": {"primary_count": 22, "additional_count": 38, "review_count": 30, "go_count": 5, "phenotype_count": 2, "disease_count": 0, "interaction_count": 51, "regulation_count": 4, "ptm_count": 9, "funComplement_count": 0, "htp_count": 8, "total_count": 141}, "disease_overview": {"manual_disease_terms": [], "htp_disease_terms": [], "computational_annotation_count": 0, "date_last_reviewed": null}, "ecnumbers": [], "URS_ID": null, "main_strain": "S288C", "genetic_position": 31.0, "regulation_overview": {"regulator_count": 3, "target_count": 0}, "reference_mapping": {"556641": 1, "549611": 2, "550252": 3, "593632": 4, "622591": 5, "470615": 6, "560352": 7, "555555": 8, "542570": 9, "536779": 10, "608643": 11, "545213": 12, "585367": 13, "554485": 14, "467934": 15, "616059": 16, "553618": 17, "609871": 18, "601509": 19, "627302": 20}, "history": [{"category": "Name", "history_type": "LSP", "note": "Name: TAF150", "date_created": "2010-02-16", "references": []}, {"category": "Name", "history_type": "LSP", "note": "Name: TAF2", "date_created": "2000-05-19", "references": [{"id": 556641, "display_name": "Tora L (2002)", "citation": "Tora L (2002) A unified nomenclature for TATA box binding protein (TBP)-associated factors (TAFs) involved in RNA polymerase II transcription. Genes Dev 16(6):673-5", "pubmed_id": 11963920, "link": "/reference/S000071622", "year": 2002, "urls": [{"display_name": "DOI full text", "link": "http://dx.doi.org/10.1101/gad.976402"}, {"display_name": "PubMed", "link": "http://www.ncbi.nlm.nih.gov/pubmed/11963920"}]}]}, {"category": "Name", "history_type": "LSP", "note": "Name: TafII150", "date_created": "2010-02-16", "references": []}, {"category": "Name", "history_type": "LSP", "note": "Name: TSM1", "date_created": "2010-02-16", "references": [{"id": 627302, "display_name": "Ray BL, et al. (1991)", "citation": "Ray BL, et al. (1991) The TSM1 gene of Saccharomyces cerevisiae overlaps the MAT locus. Curr Genet 20(1-2):25-31", "pubmed_id": 1840512, "link": "/reference/S000046664", "year": 1991, "urls": [{"display_name": "DOI full text", "link": "http://dx.doi.org/10.1007/BF00312761"}, {"display_name": "PubMed", "link": "http://www.ncbi.nlm.nih.gov/pubmed/1840512"}]}]}, {"category": "Nomenclature history", "history_type": "LSP", "note": "Nomenclature history: The names of Saccharomyces cerevisiae TBP-associated factor (TAF) genes have been changed to reflect guidelines recently enodorsed by the yeast community and published in Genes and Development. An explanation of the changes and a table with old and new gene names for S. cerevisiae, H. sapiens, D. melanogaster, C. elegans, and S. pombe may be found in the paper.", "date_created": "2002-03-25", "references": [{"id": 556641, "display_name": "Tora L (2002)", "citation": "Tora L (2002) A unified nomenclature for TATA box binding protein (TBP)-associated factors (TAFs) involved in RNA polymerase II transcription. Genes Dev 16(6):673-5", "pubmed_id": 11963920, "link": "/reference/S000071622", "year": 2002, "urls": [{"display_name": "DOI full text", "link": "http://dx.doi.org/10.1101/gad.976402"}, {"display_name": "PubMed", "link": "http://www.ncbi.nlm.nih.gov/pubmed/11963920"}]}]}, {"category": "Mapping", "history_type": "SEQUENCE", "note": "Mapping: Edition 14: TSM1 is also called TAF150", "date_created": "1997-10-20", "references": [{"id": 587084, "display_name": "Cherry JM, et al. (1997)", "citation": "Cherry JM, et al. (1997) Genetic and physical maps of Saccharomyces cerevisiae. Nature 387(6632 Suppl):67-73", "pubmed_id": 9169866, "link": "/reference/S000060841", "year": 1997, "urls": [{"display_name": "PMC full text", "link": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057085/"}, {"display_name": "PubMed", "link": "http://www.ncbi.nlm.nih.gov/pubmed/9169866"}]}]}, {"category": "Sequence change", "history_type": "SEQUENCE", "note": "Sequence change: The systematic sequence was updated in the region between ORFs YCR042C and YCR043C. Note that coordinates listed below are chromosomal coordinates.\r\n

\r\nOld:   204327 TTTATTGAATTAAATAAGACTTGATTTTGTAGCACGATATCCGCAAGAATGATTCACAAC 204386\r\n              ||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||||\r\nNew:   205589 TTTATTGAATTAAATAAGACT-GATTTTGTAGCACGATATCCGCAAGAATGATTCACAAC 205647", "date_created": "2005-12-31", "references": []}], "complexes": [{"format_name": "CPX-1642", "display_name": "General transcription factor complex TFIID"}]}


	
	
	
    
    
	
    TAF2 Gene Ontology | SGD
    
	
	
	
	
	








	
Gene Ontology Help

TAF2 / YCR042C Gene Ontology

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations.


Summary
Chromatin-binding RNA polymerase II transcription initiation factor involved in assembly of preinitiation complex; subunit of transcription factor TFIID
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

chromatin binding, DNA-templated transcription, biosynthetic process, transcription by RNA polymerase II, RNA polymerase II transcription regulator complex, transcription factor TFIID complex, transcription regulator complex

Manually Curated

Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.


Biological Process

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Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

Molecular Function

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Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

Cellular Component

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Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

High-throughput

GO annotations from high-throughput experiments are based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned to terms from all three controlled vocabularies of the Gene Ontology.


Biological Process

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Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

Molecular Function

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Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

Cellular Component

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Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

Computational

Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).


Biological Process

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Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

Molecular Function

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Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

Cellular Component

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Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

Shared Annotations

This diagram displays manually curated and high-throughput GO terms (green squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of GO terms shared (adjustable using the slider at the bottom).


Reset

Click on a gene or Biological Process GO term name to go to its specific page within SGD; drag any of the gene or GO term name objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share GO Biological Process terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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