The ICGEB research groups participate in many calls for proposals on topics relevant to their fields of interest and are supported by a vast array of donors: from Governmental bodies to private companies, and charities. Some of the major ongoing projects are shown here, divided under the Sustainable Development Goals that ICGEB strives to address in particular through its Strategic Framework, while cross-cutting actions also cover Gender equality and Youth, South-South Cooperation and Least Developed Countries.
zero hunger
Crop Improvement: Bacteriology
Developing bacterial biofertilizers for Coffea canephora (C. robusta)
Funded by the Ministry of Foreign Affairs and International Cooperation (MAECI), Government of Italy
Biotic and Abiotic Stress: Biopesticides
Enhancing trade through regulatory harmonisation and biopesticide-based residue mitigation in the SADC region
Funded by the Standards and Trade Development Facility (STDF)
Crop Improvement: Nutritional Improvement of Crops
Developing double herbicide tolerant pigeonpen for improved weed management employing two-pronged approach: haplotype mining in native germplasm and CRISPR/Cas9-mediated genome editing tool
Funded by the Department of Biotechnology (DBT), Government of India
Biotic and Abiotic Stress: Plant Stress Biology
Prions as stress sensors in plants: Role of DNA/RNA-binding proteins in regulating stress memory
Funded by the Department of Biotechnology (DBT), Government of India
Crop Improvement: Plant Systems Biology
How does Auxin improve plant salt tolerance?
Funded by the National Research Foundation (NRF), South Africa
Biotic and Abiotic Stress: Plant Transcription Regulation
Study of expression and secretion kinetics of recombinant proteins in Komagataella phaffii
Funded by the Department of Biotechnology (DBT), Government of India
ICGEB CRP and Fellowships
B-INOC AFRICA: Bioinoculants for food security in Africa
Funded by the Ministry of Foreign Affairs and International Cooperation (MAECI), Government of Italy
Additional Resources:
Booklet on ICGEB Agriculture Technology
good health
Cancer
In vivo models to study the role of genetic lesions and microenvironmental signals in driving CLL cell proliferation
Funded by AIRC
Cancer
Metastatic disease: the key to unmet need in oncology – 5 per mille 2019
Funded by AIRC MultiUnit 2020
Cardiovascular Disorders: Cardiovascular Biology
The rolE of the matRix in cAncer protection: leSsons from the hEart and novel therapeutic opportunities – ERASE
Funded by AIRC Investigator Grant 2020
Cancer
Does lung tumour development suppress the presentation of neo-epitopes by type 1 denditric cells?
Funded by AIRC Investigator Grant 2018
Cancer
Characterisation of the functions of the Human Papillomavirus E6 and E7 oncoproteins
Funded by AIRC Investigator Grant 2019
Cancer
The impact of mutant p53 dependent cellular metabolism in cancer
Funded by AIRC
Infectious Diseases
COVID-19+: Community Access Diagnostics laboratory networks
Partners
New England Biolabs, LabGene, IRSS Bobo-Dioulasso (Burkina Faso), Chantal Biya Int. Reference Centre, Ethiopian Biotech Institute (EBTi), Pasteur Institut Abidjan, Kenya Medical Research Institute – KEMRI, University of Maiduguri Teaching Hospital, Institute for Research, Epidemiological Surveillance and Training (IRESSEF), National Institute for Tropical Disease (Sudan), National Microbiology Reference Laboratory – NMRL (Burkina Faso)
Funded by the Bill & Melinda Gates Foundation
Infectious Diseases
EXPANDIA: Expanding Access to Sustainable Diagnostics in Africa
Partners
INAREES (Angola), IRSS-NIRLS (Burkina Faso), CIRCB (Cameroon), Pasteur Institut (Côte d’Ivoire – Ivory Coast), BETin (Ethiopia), KEMRI (Kenya), UMTH (Nigeria), IRESSEF (Senegal), NMRL (Zimbabwe)
Funded by the Bill & Melinda Gates Foundation
Cardiovascular Disorders:
Partners
Medizinische Universität Innsbruck
Kärnten University of Applied Science
Co-funded by the European Union
Rare Diseases
cGAS-STING driven activation of type-I interferone in Wiskott-Aldrich syndrome
Funded by Fondazione Telethon
Rare Diseases
Liver-directed promotierless gene targeting without the use of nucleases as a potential therapy for Fabry disease
Funded by Fondazione Telethon
Infectious Diseases
TBFVnet: surveillance and research on tick-borne aviviruses (TBFV)
Partners
Veterinary Res. Institute – Czech Republic, Chumakov Federal Scientific Centre – Russia, Biomedical Research Centre Slovak Academy of Sciences, Norwegian Institute of Public Health – Norway, Umea University – Sweden
Funded by the Norway Grants Fund
Rare Diseases
Combination of mRNA-LNP and gene-targeting approaches as a potential cure for early-onset severe ornithine transcarbamylase deficiency
Funded by AFM Telethon
Cancer
The Role of Mirnas in AxL-Medicated Docetaxel and Carbazitaxel Resistance
Funded by the National Research Foundation (NRF), South Africa
Cancer
Mechanistic Characterization of the E3 ligase DCUNIDI in Prostate Cancer
Funded by the National Research Foundation (NRF), South Africa
Cardiovascular Disorders: Cardiovascular Biology
INCardio – INnovative therapies for the treatment of Cardiovascular diseases
Partners
Medizinische Universität Innsbruck
Kärnten University of Applied Science
Funded by the European Regional Development Fund and Interreg V-A Italy-Austria
Tuberculosis
DBT- Supported Tuberculosis Aerosol Challenge Facility (DBT-TACF): maintenance and operation
Funded by the Department of Biotechnology (DBT), Government of India
Tuberculosis
Development of saracatinib-based immunomodulatory regimens for treatment of MDR tuberculosis
Funded by the Biotechnology Industry Research Assistance Council (BIRAC), Government of India
Drug resistance
Whole-genome sequencing of MTB clinical strains for determining drug resistance and strain lineage in India: A structured nationwide approach
Funded by the Department of Biotechnology (DBT), Government of India
Tuberculosis
Towards an evidence-based regimen for treating Extra-Pulmonary Tuberculosis (EPTB)
Funded by the Department of Biotechnology (DBT), Government of India
HIV/AIDS
Evaluation of clinical characteristics and risk factors for elevated blood-based KSHV viral load in South African AIDS patients
Funded by the National Research Foundation (NRF), South Africa
Infectious Diseases
KSHV and EBV reactivation and associated tumorigenesis amidst Covid-19
Funded by the Poliomyelitis Research Foundation (PRF), South Africa
Dengue
Translational Research Consortium for establishing platform technologies to support prophylactic and therapeutic strategies for dengue discovery to proof of concept
Funded by the Biotechnology Industry Research Assistance Council (BIRAC), Government of India
Respiratory Diseases
HTS screening to identify human microRNAs able to regulate ATII to ATI trans differentiation
Funded by Danube Labs/Cebina
Immunology: Immunobiology
Understanding the epigenetic regulation of T-cell responses during tuberculosis
Funded by the Department of Biotechnology (DBT), Government of India
Immunology: Immunobiology
Determining the efficacy of bioactive Tuberculinum as adjunct therapy against drug-susceptible and drug-resistant Tuberculosis
Funded by the Central Council For Research In Homoeopathy (CCRH), Government of India
Parasitic Diseases: Malaria Biology
Functional and structural dissection of Plasmodium falciparum novel protein families: Ankyrin repeat domain containing family and RAP Family
Funded by the Department of Biotechnology (DBT), Government of India
Immunology: Structural Immunology
DBT-BioCARe Processing and Monitoring Unit (PMU)
Funded by the Department of Biotechnology (DBT), Government of India
Immunology: Structural Immunology
Establishment of DBT Apex Biotechnology Information Centre (BTIC)
Funded by the Department of Biotechnology (DBT), Government of India
Immunology: Structural Immunology
Drug development project for malaria and tuberculosis
Funded by the Department of Biotechnology (DBT), Government of India
Cancer: Structural Biology
Preclinical evaluation of novel inhibitors for cardiovascular therapy, targeting oxidized low-density lipoprotein receptor (LOX-1)
Funded by the Indian Council of Medical Research (ICMR), Government of India
Cardiovascular Disorders: Molecular Medicine
CardioRiGen
Partner
Azienda Sanitaria Universitaria Integrata Trieste ASUITS (Struttura complessa di Cardiologia)
Funded by Fondazione CRTrieste
Cardiovascular Disorders: Molecular Medicine
Further assessments on the cardioprotective properties of Chrdl1, Fam3b and Fam3c
Funded by Forcefield Therapeutics Ltd
Neurobiology: Molecular Pathology
Full-length RGNEF and/or “RGNEF leucine–rich domain” as a therapeutic target in ALS
Funded by Western Ontario University
Neurobiology: Molecular Pathology
Novel therapeutic targets derived from modulation of RNA metabolism in late onset Pompe disease
Funded by AFM Telethon
Neurobiology: Molecular Pathology
Marie Skłodowska-Curie fellowship for Discovery of new Frontal Temporal Dementia multimodal spectral markers in biofluids
Funded by Research Executive Agency (REA- European Commission)
Biotic and Abiotic Stress: Plant RNAi Biology
Understanding the role of CIB-associated B-satellites in plant – virus interactions
Funded by the Department of Biotechnology (DBT), Government of India
Biotic and Abiotic Stress: Plant Stress Biology
Generating high-depth genomics information for the Himalaya rice cultivars for improving nutritional quality and stress tolerance
Funded by the Department of Biotechnology (DBT), Government of India
Biotic and Abiotic Stress: Plant Transcription Regulation
Structural and functional analysis of arabidopsis mediator complex
Funded by the Department of Biotechnology (DBT), Government of India
Parasitic Diseases: Structural Parasitology
Exploiting diversity-oriented chemical synthesis for combating chronic parasitic infection
Funded by the National Institute of Health and Family Welfare, Government of India
Parasitic Diseases: Structural Parasitology
Advancing hit-to-lead discovery against malaria parasites by targeting protein and nucleic acid synthesis pathways
Funded by the Department of Biotechnology (DBT), Government of India
Medical Biotechnology: Translational Bioinformatics
Establishment of Bioinformatics and computational biology centre for high-throughput data analysis
Funded by the Department of Biotechnology (DBT), Government of India
Recombinant Diagnostics and Vaccines: Translational Health
Sepsis-related mortality in neonates in India: A multi-disciplinary, multi-institutional research program for context-specific solutions
Funded by the Department of Biotechnology (DBT), Government of India
Cancer: Tumour Virology
AIRC Fellowship: The role of HPV onco-protein E7 in the context of oxidative stress and tumorigenesis
Funded by AIRC
Virology: Vector-borne Diseases
Translational research consortia TRC for Chikungunya virus
Funded by the Biotechnology Industry Research Assistance Council (BIRAC), Government of India
Virology: Vector-borne Diseases
Comparative and combined efficacy evaluation of extracts of Nilavembu kudineer and vathasura kudineer
Funded by the Ministry of Ayush, Government of India
Cardiovascular Disorders: Cardiovascular Biology
Coherence – Cross bOrder HEalth REgulatory alliaNCE for advanced therapies
Co-funded by the European Union
Respiratory Diseases: Functional Cell Biology
Funded by the Regione Friuli-Venezia Giulia, Cluster Scienze della Vita and Polo Tecnologico Alto Adriatico Andrea Galvani
quality education
ICGEB Cape Town
ICGEB Special Programme with South African Historically Disadvantaged Institutions (HDIs)
Funded by the Department of Science and Innovation (DSI), South Africa
ICGEB CRP and Fellowships, Trieste
Support for A. Falaschi fellows from developing countries in biology, biophysics, life sciences and biotechnology
Funded by Elettra-Sincrotrone
ICGEB Fellowships
Support for A. Falaschi short-term fellows from Kenya, U.R. Tanzania and Uganda in biotechnology
Funded by the African Institute for Capacity Development (AICAD)
Neurobiology: Molecular Pathology
InfraRed for Frontal Temporal Dementia – IR4FTD
Funded by the European Commission Marie Skłodowska-Curie Actions
Postdoctoral Fellowship
ICGEB CRP and Fellowships
BIOTECHNET – Enhancing biotechnology know-how in the Horn of Africa (AID n.12098)
Funded by the Italian Agency for Development Cooperation (AICS)
ICGEB Fellowships
PACTS UNTBLDC-TWAS-ICGEB Joint Proposal for a ProgrAme of CollaboraTions with LDC-PACTS
Funded by the UN Technology Bank for the Least Developed Countries
Cancer: Cancer Genomics
Professional Development Programme
Funded by the National Research Foundation (NRF), South Africa
Virology: ICGEB Emory-Vaccine Programme
Early-Career fellowship programme
Funded by Wellcome Trust Alliance
ICGEB Fellowships
WESTAR – PhD and Postdoctoral training scheme for WomEn ScienTists in Africa
Funded by the Ministry of Foreign Affairs and International Cooperation (MAECI), Government of Italy
ICGEB Fellowships
EMPOWERing participation of Women Scientists from the Global South in Science Technology and Innovation
Funded by the United Nations Office for South-South Cooperation (UNOSSC)
ICGEB Cape Town
Student Mobility – South African Women in Biotechnology Programme
Funded by the Department of Science and Innovation (DSI), South Africa
Parasitic Diseases: Malaria Biology; Immunology: Structural Immunology
J C Bose fellowship
Funded by the Department of Science and Technology (DST), Government of India
affordable energy
Biofuels and Industrial Biotechnology: Metabolic Engineering
Hydrocarbons from synthetic microbes and scale-up processing
Funded by the Department of Biotechnology (DBT), Government of India
Biofuels and Industrial Biotechnology: Microbial Engineering
Metabolic engineering of escherichia coli for 1,4 butanediol production
Funded by the Bharat Petroleum Corporation Ltd.
Biofuels and Industrial Biotechnology: Microbial Engineering
A novel fungal host platform for high-level expression of heterologous proteins
Funded by The Live Green Group Inc.
Biofuels and Industrial Biotechnology: Microbial Engineering
Strain and protein engineering of Penicillium marneffei for enhanced and efficient celluloytic enzyme production
Funded by the Hindustan Petroleum Corporation Ltd.
industry innovation
life on land
partnership for the goals
CUTTiNG 2020
Funded by the Ministry of Economic Development, Government of Italy
Joint Scientific Cooperation Programme for Research Grants and Fellowships
Funded by the Ministerial Standing Committee on Scientific and Technological Cooperation of the OIC (Organization of Islamic Cooperation) – COMSTECH
Development of the outline for the additional voluntary guidance materials to support the risk assessment of living modified organisms containing engineered gene drives
Funded by the Convention on Biological Diversity
Trainers and Facilitators for IUCN Policy on Synthetic Biology for Nature Conservation Development Process
Funded by the International Union for Conservation of Nature and Natural Resources (IUCN)
BIO-GUARD: A Global initiative to enhance biological security in low-resource settings
Funded by the Norwegian Ministry of Foreign Affairs, the Implementation Support Unit (ISU) of the BWC and the Italian Ministry of Foreign Affairs