Pdr5p is a member of the ATP-binding cassette (ABC) family of proteins, a large group that are conserved from bacteria to humans (3 and references therein). Overexpression of the human ABC transporter ABCB1/MDR1 (OMIM) is a factor in tumor resistance to drug therapy, and deficient ABC transporter function has been implicated in other human diseases as well (reviewed in 27). S. cerevisiae ABC proteins are often used as a model to study the clinical problem of drug resistance in infectious disease and cancer as well as in pharmaceutical screens for novel drugs (28 and reviewed in 29).", "date_edited": "2007-11-06"}, "literature_overview": {"primary_count": 251, "additional_count": 266, "review_count": 76, "go_count": 11, "phenotype_count": 33, "disease_count": 0, "interaction_count": 80, "regulation_count": 13, "ptm_count": 16, "funComplement_count": 0, "htp_count": 34, "total_count": 682}, "disease_overview": {"manual_disease_terms": [], "htp_disease_terms": [], "computational_annotation_count": 0, "date_last_reviewed": null}, "ecnumbers": [], "URS_ID": null, "main_strain": "S288C", "genetic_position": 85.0, "regulation_overview": {"regulator_count": 21, "target_count": 0, "paragraph": {"text": "PDR5 transcription is upregulated by Pdr1p, Pdr3p, and SWI/SNF in response to xenobiotics; PDR5 transcription is also upregulated by Rtt106p and Ume6p", "date_edited": "2023-10-11", "references": [{"id": 642183, "display_name": "Katzmann DJ, et al. (1996)", "citation": "Katzmann DJ, et al. (1996) Multiple Pdr1p/Pdr3p binding sites are essential for normal expression of the ATP binding cassette transporter protein-encoding gene PDR5. J Biol Chem 271(38):23049-54", "pubmed_id": 8798494, "link": "/reference/S000041650", "year": 1996, "urls": [{"display_name": "DOI full text", "link": "http://dx.doi.org/10.1074/jbc.271.38.23049"}, {"display_name": "PubMed", "link": "http://www.ncbi.nlm.nih.gov/pubmed/8798494"}]}, {"id": 2399958, "display_name": "Nikolov VN, et al. (2022)", "citation": "Nikolov VN, et al. (2022) SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes. Nat Commun 13(1):1968", "pubmed_id": 35413952, "link": "/reference/S000315437", "year": 2022, "urls": [{"display_name": "DOI full text", "link": "http://dx.doi.org/10.1038/s41467-022-29591-z"}, {"display_name": "PMC full text", "link": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005695/"}, {"display_name": "PubMed", "link": "http://www.ncbi.nlm.nih.gov/pubmed/35413952"}]}, {"id": 2370295, "display_name": "Yamada Y (2021)", "citation": "Yamada Y (2021) RPD3 and UME6 are involved in the activation of PDR5 transcription and pleiotropic drug resistance in \u03c10 cells of Saccharomyces cerevisiae. BMC Microbiol 21(1):311", "pubmed_id": 34753419, "link": "/reference/S000310804", "year": 2021, "urls": [{"display_name": "DOI full text", "link": "http://dx.doi.org/10.1186/s12866-021-02373-1"}, {"display_name": "PMC full text", "link": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576940/"}, {"display_name": "PubMed", "link": "http://www.ncbi.nlm.nih.gov/pubmed/34753419"}]}]}}, "reference_mapping": {"647614": 1, "588911": 2, "641028": 3, "638262": 4, "635889": 5, "609355": 6, "645118": 7, "639493": 8, "561250": 9, "544370": 10, "526423": 11, "524983": 12, "506952": 13, "634111": 14, "616928": 15, "637318": 16, "532733": 17, "475668": 18, "552834": 19, "646650": 20, "507274": 21, "527855": 22, "635778": 23, "561389": 24, "642183": 25, "623357": 26, "593793": 27, "501202": 28, "522903": 29, "621337": 30, "638792": 31}, "history": [{"category": "Name", "history_type": "LSP", "note": "Name: PDR5", "date_created": "2000-05-19", "references": [{"id": 647614, "display_name": "Leppert G, et al. (1990)", "citation": "Leppert G, et al. (1990) Cloning by gene amplification of two loci conferring multiple drug resistance in Saccharomyces. Genetics 125(1):13-20", "pubmed_id": 2160400, "link": "/reference/S000039204", "year": 1990, "urls": [{"display_name": "DOI full text", "link": "http://dx.doi.org/10.1093/genetics/125.1.13"}, {"display_name": "PMC full text", "link": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1203995/"}, {"display_name": "PubMed", "link": "http://www.ncbi.nlm.nih.gov/pubmed/2160400"}]}]}, {"category": "Name", "history_type": "LSP", "note": "Name: STS1", "date_created": "2010-02-16", "references": [{"id": 638262, "display_name": "Bissinger PH and Kuchler K (1994)", "citation": "Bissinger PH and Kuchler K (1994) Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance. J Biol Chem 269(6):4180-6", "pubmed_id": 8307980, "link": "/reference/S000042972", "year": 1994, "urls": [{"display_name": "PubMed", "link": "http://www.ncbi.nlm.nih.gov/pubmed/8307980"}]}]}, {"category": "Name", "history_type": "LSP", "note": "Name: YDR1", "date_created": "2010-02-16", "references": [{"id": 638792, "display_name": "Hirata D, et al. (1994)", "citation": "Hirata D, et al. (1994) Saccharomyces cerevisiae YDR1, which encodes a member of the ATP-binding cassette (ABC) superfamily, is required for multidrug resistance. Curr Genet 26(4):285-94", "pubmed_id": 7882421, "link": "/reference/S000042792", "year": 1994, "urls": [{"display_name": "DOI full text", "link": "http://dx.doi.org/10.1007/BF00310491"}, {"display_name": "PubMed", "link": "http://www.ncbi.nlm.nih.gov/pubmed/7882421"}]}]}, {"category": "Name", "history_type": "LSP", "note": "Name: LEM1", "date_created": "2010-02-16", "references": [{"id": 621337, "display_name": "Kralli A, et al. (1995)", "citation": "Kralli A, et al. (1995) LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones. Proc Natl Acad Sci U S A 92(10):4701-5", "pubmed_id": 7753868, "link": "/reference/S000048680", "year": 1995, "urls": [{"display_name": "DOI full text", "link": "http://dx.doi.org/10.1073/pnas.92.10.4701"}, {"display_name": "PMC full text", "link": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC42012/"}, {"display_name": "PubMed", "link": "http://www.ncbi.nlm.nih.gov/pubmed/7753868"}]}]}, {"category": "Nomenclature history", "history_type": "LSP", "note": "Nomenclature history: The name STS1 was once used by Bissinger and Kuchler, 1994. for the gene now referred to as PDR5/YOR153W. The name STS1 is now used for STS1/YIR011C, a protein involved in ubiquitin-dependent protein catabolism.", "date_created": "2003-02-12", "references": [{"id": 638262, "display_name": "Bissinger PH and Kuchler K (1994)", "citation": "Bissinger PH and Kuchler K (1994) Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance. J Biol Chem 269(6):4180-6", "pubmed_id": 8307980, "link": "/reference/S000042972", "year": 1994, "urls": [{"display_name": "PubMed", "link": "http://www.ncbi.nlm.nih.gov/pubmed/8307980"}]}]}, {"category": "Nomenclature conflict", "history_type": "LSP", "note": "Nomenclature conflict: The name STS1 has been used to describe both PDR5/YOR153W, a transporting ATPase involved in multidrug resistance, and STS1/YIR011C, a protein involved in ubiquitin-dependent protein catabolism.", "date_created": "2003-12-09", "references": []}, {"category": "Nomenclature conflict", "history_type": "LSP", "note": "Nomenclature conflict: YDR1 has been used in the literature to refer to both PDR5/YOR153W, which encodes a multi drug transporter, and NCB2/YDR397C, which encodes the beta subunit of a negative regulator of RNA Polymerase II holoenzyme.", "date_created": "2003-12-09", "references": []}, {"category": "Mapping", "history_type": "SEQUENCE", "note": "Mapping: Edition 13: YDR1 has also been used to refer to NCB2/YDR397C on chromosome IV.", "date_created": "1996-09-21", "references": [{"id": 542519, "display_name": "Cherry JM, et al. (1996)", "citation": "Cherry JM, et al. (1996) \"Genetic and Physical Maps of Saccharomyces cerevisiae (Edition 13)\". Pp. 361-364 in 1996 Yeast Genetics and Molecular Biology Meeting Program and Abstracts. Bethesda, MD: The Genetics Society of America", "pubmed_id": null, "link": "/reference/S000076283", "year": 1996, "urls": []}]}, {"category": "Mapping", "history_type": "SEQUENCE", "note": "Mapping: Edition 13: PDR5/YOR153W has also been called STS1. However, it should not be confused with the protein involved in protein transport on chr IX known at STS1/YIR011C.", "date_created": "1996-09-21", "references": [{"id": 542519, "display_name": "Cherry JM, et al. (1996)", "citation": "Cherry JM, et al. (1996) \"Genetic and Physical Maps of Saccharomyces cerevisiae (Edition 13)\". Pp. 361-364 in 1996 Yeast Genetics and Molecular Biology Meeting Program and Abstracts. Bethesda, MD: The Genetics Society of America", "pubmed_id": null, "link": "/reference/S000076283", "year": 1996, "urls": []}]}], "complexes": []},
tabs: {"id": 1285518, "protein_tab": true, "interaction_tab": true, "summary_tab": true, "go_tab": true, "sequence_section": true, "expression_tab": true, "phenotype_tab": true, "literature_tab": true, "wiki_tab": false, "regulation_tab": true, "sequence_tab": true, "history_tab": true, "homology_tab": true, "disease_tab": false}
};
The S. cerevisiae Reference Genome sequence is derived from laboratory strain
S288C. Download DNA or protein sequence, view genomic context and
coordinates. Click "Sequence Details" to view all sequence information for this locus, including that
for other strains.
BLASTN |
BLASTP |
Design Primers |
Restriction Fragment Map |
Restriction Fragment Sizes |
Six-Frame Translation
BLASTN vs. fungi |
BLASTP at NCBI |
BLASTP vs. fungi
Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.
Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.
View all PDR5 alleles in SGD search
GO Annotations consist of four mandatory components: a gene product, a term from one of the three
Gene Ontology (GO) controlled vocabularies
(Molecular Function,
Biological Process, and
Cellular Component), a reference, and an
evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the
literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view
all GO information and evidence for this locus as well as biological processes it shares with other genes.
View computational annotations
Phenotype annotations for a gene are curated single mutant phenotypes that require an observable
(e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background,
and a reference. In addition, annotations are classified as classical genetics or high-throughput
(e.g., large scale survey, systematic mutation set). Whenever possible, allele information and
additional details are provided. Click "Phenotype Details" to view all phenotype annotations and
evidence for this locus as well as phenotypes it shares with other genes.
Interaction annotations are curated by BioGRID and include physical
or genetic interactions observed
between at least two genes. An interaction annotation is composed of the interaction type, name of the
interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a
reference, as well as other experimental details. Click "Interaction Details" to view all interaction
annotations and evidence for this locus, including an interaction visualization.
232 total interactions for 168 unique genes
The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the
given locus, based on experimental evidence. This evidence includes data generated through
high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO
enrichment among regulation Targets, and a regulator/target diagram for the locus.
Expression data are derived from records contained in the
Gene Expression Omnibus (GEO), and are first log2
transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result
there may be a greater number of conditions than datasets represented in a single clickable histogram
bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from
those that are up-regulated (red). Click "Expression Details" to view all expression annotations and
details for this locus, including a visualization of genes that share a similar expression pattern.
A summary of the locus, written by SGD Biocurators following a thorough review of the literature. Links
to gene names and curated GO terms are included within the Summary Paragraphs.
Last Updated: 2007-11-06
All manually curated literature for the specified gene, organized into topics according to their
relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details"
to view all literature information for this locus, including shared literature between genes.
PDR5 / YOR153W Overview
Sequence
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Protein
Alleles
Gene Ontology
Molecular Function
Biological Process
Cellular Component
Phenotype
Classical Genetics
Large-scale Survey
Interaction
Physical Interactions
Genetic Interactions
Regulation
Expression
Summary Paragraph
Literature
Resources