| Joshua Dunne | 10/25/2025 | C | Called up from minors (The Buffalo Sabres recalled F Joshua Dunne from the minors.) |
| Tyson Kozak | 10/25/2025 | C | Placed on Injured Reserve (The Buffalo Sabres placed F Tyson Kozak on injured reserve.) |
| Ukko-Pekka Luukkonen | 10/23/2025 | G | Called up from minors (The Buffalo Sabres recalled G Ukko-Pekka Luukkonen from his conditioning assignment.) |
| Joshua Dunne | 10/22/2025 | C | Sent to minors (The Buffalo Sabres sent F Josh Dunne to the minors.) |
| Beck Malenstyn | 10/22/2025 | LW | Called up from minors (The Buffalo Sabres recalled F Beck Malenstyn from the minors.) |
| Zachary Jones | 10/21/2025 | D | Sent to minors (The Buffalo Sabres sent D Zachary Jones to the minors.) |
| Beck Malenstyn | 10/20/2025 | LW | Sent to minors (The Buffalo Sabres sent F Beck Malenstyn to the minors.) |
| Noah Ostlund | 10/19/2025 | C | Called up from minors (The Buffalo Sabres recalled F Noah Ostlund from the minors.) |
| Zachary Jones | 10/19/2025 | D | Called up from minors (The Buffalo Sabres recalled D Zac Jones from the minors.) |
| Justin Danforth | 10/18/2025 | RW | Placed on Injured Reserve (The Buffalo Sabres placed F Justin Danforth on Injured Reserve.) |
| Zach Metsa | 10/16/2025 | D | Called up from minors (The Buffalo Sabres recalled D Zach Metsa from the minors.) |
| Zach Metsa | 10/16/2025 | D | Called up from minors (The Buffalo Sabres recalled D Zach Metsa from the minors.) |
| Ryan Johnson | 10/16/2025 | D | Sent to minors (The Buffalo Sabres assigned D Ryan Johnson to the minors.) |
| Joshua Norris | 10/11/2025 | C | Placed on Injured Reserve (The Buffalo Sabres placed F Joshua Norris on injured reserve.) |
| Owen Power | 10/11/2025 | D | Activated (The Buffalo Sabres activated D Owen Power from injured reserve.) |
| Joshua Dunne | 10/10/2025 | C | Called up from minors (The Buffalo Sabres recalled F Joshua Dunne from the minors.) |
| Alexandar Georgiev | 10/7/2025 | G | Waived (The Buffalo Sabres waived G Alexandar Georgiev.) |
| Carson Meyer | 10/7/2025 | RW | Placed on Injured Reserve (The Buffalo Sabres placed F Carson Meyer on the Injured Reserve.) |
| Owen Power | 10/7/2025 | D | Placed on Injured Reserve (The Buffalo Sabres placed D Owen Power on the Injured Reserves.) |
| Michael Kesselring | 10/6/2025 | D | Placed on Injured Reserve (The Buffalo Sabres placed D Michael Kesselring on the Injured reserve.) |
| Ukko-Pekka Luukkonen | 10/6/2025 | G | Placed on Injured Reserve (The Buffalo Sabres placed G Ukko-Pekka Luukkonen on the Injured Reserve.) |
| Jordan Greenway | 10/6/2025 | LW | Placed on Injured Reserve (The Buffalo Sabres placed F Jordan Greenway on the Injured Reserve.) |
| Colten Ellis | 10/6/2025 | G | Claimed (The Buffalo Sabres claimed G Colten Ellis off waivers from the St. Louis Blues.) From St. Louis |
| Joshua Dunne | 10/5/2025 | C | Sent to minors (The Buffalo Sabres sent F Josh Dunne to the minors.) |
| Radim Mrtka | 10/4/2025 | D | Sent to minors (The Buffalo Sabres sent D Radim Mrtka to the minors.) |
| Zach Metsa | 10/4/2025 | D | Sent to minors (The Buffalo Sabres sent D Zach Metsa to the minors.) |
| Noah Ostlund | 10/4/2025 | C | Sent to minors (The Buffalo Sabres sent F Noah Ostlund to the minors.) |
| Vsevolod Komarov | 10/4/2025 | D | Sent to minors (The Buffalo Sabres sent D Vsevolod Komarov to the minors.) |
| Zach Metsa | 10/3/2025 | D | Called up from minors (The Buffalo Sabres recalled D Zach Metsa from the minors.) |
| Vsevolod Komarov | 9/29/2025 | D | Called up from minors (The Buffalo Sabres recalled D Vsevolod Komarov from the minors.) |
| Jake Leschyshyn | 9/28/2025 | C | Waived (The Buffalo Sabres waived F Jake Leschyshyn.) |
| Zachary Jones | 9/28/2025 | D | Waived (The Buffalo Sabres waived D Zac Jones.) |
| Graham Slaggert | 9/27/2025 | C | Sent to minors (The Buffalo Sabres sent F Graham Slaggert to the minors.) |
| Brendan Warren | 9/27/2025 | LW | Sent to minors (The Buffalo Sabres sent F Brendan Warren to the minors.) |
| Noah Laaouan | 9/27/2025 | D | Sent to minors (The Buffalo Sabres sent D Noah Laaouan to the minors.) |
| Trevor Kuntar | 9/27/2025 | C | Sent to minors (The Buffalo Sabres sent F Trevor Kuntar to the minors.) |
| Redmond Savage | 9/27/2025 | C | Sent to minors (The Buffalo Sabres sent F Redmond Savage to the minors.) |
| Aidan Fulp | 9/27/2025 | D | Sent to minors (The Buffalo Sabres sent D Aidan Fulp to the minors.) |
| Peter Tischke | 9/27/2025 | D | Sent to minors (The Buffalo Sabres sent D Peter Tischke to the minors.) |
| Nikita Novikov | 9/27/2025 | D | Sent to minors (The Buffalo Sabres sent D Nikita Novikov to the minors.) |
| Anton Wahlberg | 9/27/2025 | C | Sent to minors (The Buffalo Sabres sent F Anton Wahlberg to the minors.) |
| Isak Rosen | 9/27/2025 | RW | Sent to minors (The Buffalo Sabres sent F Isak Rosen to the minors.) |
| Vsevolod Komarov | 9/27/2025 | D | Sent to minors (The Buffalo Sabres sent D Vsevolod Komarov to the minors.) |
| Devon Levi | 9/27/2025 | G | Sent to minors (The Buffalo Sabres sent G Devon Levi to the minors.) |
| Jagger Joshua | 9/27/2025 | LW | Sent to minors (The Buffalo Sabres sent F Jagger Joshua to the minors.) |
| Riley Fiddler-Schultz | 9/27/2025 | C | Sent to minors (The Buffalo Sabres sent F Riley Fiddler-Schultz to the minors.) |
| Scott Ratzlaff | 9/27/2025 | G | Sent to minors (The Buffalo Sabres sent G Scott Ratzlaff to the minors.) |
| Tyler Kopff | 9/27/2025 | LW | Sent to minors (The Buffalo Sabres sent F Tyler Kopff to the minors.) |
| Isaac Belliveau | 9/27/2025 | D | Sent to minors (The Buffalo Sabres sent D Isaac Belliveau to the minors.) |
| Zach Metsa | 9/27/2025 | D | Sent to minors (The Buffalo Sabres sent D Zach Metsa to the minors.) |
| Matteo Costantini | 9/27/2025 | C | Sent to minors (The Buffalo Sabres sent F Matteo Costantini to the minors.) |
| Konsta Helenius | 9/27/2025 | C | Sent to minors (The Buffalo Sabres sent F Konsta Helenius to the minors.) |
| Olivier Nadeau | 9/27/2025 | RW | Sent to minors (The Buffalo Sabres sent F Olivier Nadeau to the minors.) |
| Topias Leinonen | 9/27/2025 | G | Sent to minors (The Buffalo Sabres sent G Topias Leinonen to the minors.) |
| Viktor Neuchev | 9/27/2025 | LW | Sent to minors (The Buffalo Sabres sent F Viktor Neuchev to the minors.) |
| Jack Rathbone | 9/27/2025 | D | Waived (The Buffalo Sabres waived D Jack Rathbone.) |
| Noah Laberge | 9/26/2025 | D | Sent to minors (The Buffalo Sabres sent D Noah Laberge to the minors.) |
| Ryerson Leenders | 9/26/2025 | G | Sent to minors (The Buffalo Sabres sent G Ryerson Leenders to the minors.) |
| David Bedkowski | 9/19/2025 | D | Sent to minors (The Buffalo Sabres sent D David Bedkowski to the minors.) |
| Simon-Pier Brunet | 9/19/2025 | D | Sent to minors (The Buffalo Sabres sent D Simon-Pier Brunet to the minors.) |
| Samuel Meloche | 9/19/2025 | G | Sent to minors (The Buffalo Sabres sent G Samuel Meloche to the minors.) |
| Graham Slaggert | 9/17/2025 | C | Signed (The Buffalo Sabres signed F Graham Slaggert to a training camp contract.) |
| Vsevolod Komarov | 9/17/2025 | D | Signed (The Buffalo Sabres signed D Vsevolod Komarov to a training camp contract.) |
| Noah Laaouan | 9/17/2025 | D | Signed (The Buffalo Sabres signed D Noah Laaouan to a training camp contract.) |
| Ryerson Leenders | 9/17/2025 | G | Signed (The Buffalo Sabres signed G Ryerson Leenders to a training camp contract.) |
| Simon-Pier Brunet | 9/17/2025 | D | Signed (The Buffalo Sabres signed D Simon-Pier Brunet to a training camp contract.) |
| Topias Leinonen | 9/17/2025 | G | Signed (The Buffalo Sabres signed G Topias Leinonen to a training camp contract.) |
| Jack Rathbone | 9/17/2025 | D | Signed (The Buffalo Sabres signed D Jack Rathbone to a training camp contract.) |
| Scott Ratzlaff | 9/17/2025 | G | Signed (The Buffalo Sabres signed G Scott Ratzlaff to a training camp contract.) |
| Peter Tischke | 9/17/2025 | D | Signed (The Buffalo Sabres signed D Peter Tischke to a training camp contract.) |
| Zach Metsa | 9/17/2025 | D | Signed (The Buffalo Sabres signed D Zach Metsa to a training camp contract.) |
| Radim Mrtka | 9/17/2025 | D | Signed (The Buffalo Sabres signed D Radim Mrtka to a training camp contract.) |
| Devon Levi | 9/17/2025 | G | Signed (The Buffalo Sabres signed G Devon Levi to a training camp contract.) |
| Aidan Fulp | 9/17/2025 | D | Signed (The Buffalo Sabres signed D Aidan Fulp to a training camp contract.) |
| Trevor Kuntar | 9/17/2025 | C | Signed (The Buffalo Sabres signed F Trevor Kuntar to a training camp contract.) |
| Anton Wahlberg | 9/17/2025 | C | Signed (The Buffalo Sabres signed F Anton Wahlberg to a training camp contract.) |
| Isaac Belliveau | 9/17/2025 | D | Signed (The Buffalo Sabres signed F Isaac Belliveau to a training camp contract.) |
| Konsta Helenius | 9/17/2025 | C | Signed (The Buffalo Sabres signed F Konsta Helenius to a training camp contract.) |
| Olivier Nadeau | 9/17/2025 | RW | Signed (The Buffalo Sabres signed F Olivier Nadeau to a training camp contract.) |
| Redmond Savage | 9/17/2025 | C | Signed (The Buffalo Sabres signed F Redmond Savage to a training camp contract.) |
| Brendan Warren | 9/17/2025 | LW | Signed (The Buffalo Sabres signed F Brendan Warren to a training camp contract.) |
| Isak Rosen | 9/17/2025 | RW | Signed (The Buffalo Sabres signed F Isak Rosen to a training camp contract.) |
| Graham Slaggert | 9/17/2025 | C | Signed (The Buffalo Sabres signed F Graham Slaggert to a training camp contract.) |
| Jagger Joshua | 9/17/2025 | LW | Signed (The Buffalo Sabres signed F Jagger Joshua to a training camp contract.) |
| Jiri Kulich | 9/17/2025 | C | Signed (The Buffalo Sabres signed F Jiri Kulich to a training camp contract.) |
| Mason Geertsen | 9/17/2025 | LW | Signed (The Buffalo Sabres signed F Mason Geertsen to a training camp contract.) |
| Matteo Costantini | 9/16/2025 | C | Signed (The Buffalo Sabres signed F Matteo Costantini to a training camp contract.) |
| Noah Laberge | 9/16/2025 | D | Signed (The Buffalo Sabres signed D Noah Laberge to a training camp contract.) |
| Riley Fiddler-Schultz | 9/16/2025 | C | Signed (The Buffalo Sabres signed F Riley Fiddler-Schultz to a training camp contract.) |
| Samuel Meloche | 9/16/2025 | G | Signed (The Buffalo Sabres signed G Samuel Meloche to a training camp contract.) |
| Yevgeni Prokhorov | 9/16/2025 | G | Sent to minors (The Buffalo Sabres sent to the minors.) |
| David Bedkowski | 9/16/2025 | D | Signed (The Buffalo Sabres signed D David Bedkowski to a training camp contract.) |
| Ryan Rucinski | 9/16/2025 | C | Sent to minors (The Buffalo Sabres sent F Ryan Rucinski to the minors.) |
| Ashton Schultz | 9/16/2025 | C | Sent to minors (The Buffalo Sabres sent F Ashton Schultz to the minors.) |
| Matous Kucharcik | 9/16/2025 | C | Sent to minors (The Buffalo Sabres sent F Matous Kucharcik to the minors.) |
| Melvin Novotny | 9/16/2025 | LW | Sent to minors (The Buffalo Sabres sent F Melvin Novotny to the minors.) |
| Alexandar Georgiev | 9/12/2025 | G | Signed (The Buffalo Sabres signed G Alexandar Georgiev.) |
| Alexandar Georgiev | 9/11/2025 | G | Signed (The Buffalo Sabres signed G Alexandar Georgiev.) |
| Noah Ostlund | 9/9/2025 | C | Activated (The Buffalo Sabres activated F Noah Ostlund from the minors.) |
| Joshua Dunne | 9/9/2025 | C | Activated (The Buffalo Sabres activated F Josh Dunne from the minors.) |
| Devon Levi | 7/31/2025 | G | Signed (The Buffalo Sabres signed G Devon Levi.) |
| Jake Leschyshyn | 7/16/2025 | C | Signed (The Buffalo Sabres signed F Jake Leschyshyn to a two-way contract.) |
| Radim Mrtka | 7/15/2025 | D | Signed (The Buffalo Sabres signed D Radim Mrtka to an entry-level contract.) |
| Bowen Byram | 7/15/2025 | D | Contract extended (The Buffalo Sabres signed D Bowen Byram to a contract extension.) |
| Riley Fiddler-Schultz | 7/2/2025 | C | Signed (The Buffalo Sabres signed F Riley Fiddler-Schultz to an entry-level contract.) |
| Carson Meyer | 7/1/2025 | RW | Signed (The Buffalo Sabres signed F Carson Meyer to a two-way contract.) |
| Mason Geertsen | 7/1/2025 | LW | Signed (The Buffalo Sabres signed D Mason Geertsen.) |
| Zachary Jones | 7/1/2025 | D | Signed (The Buffalo Sabres signed D Zac Jones to a two-way contract.) |
| Zachary Jones | 7/1/2025 | D | Signed (The Buffalo Sabres signed D Zac Jones to a two-way contract.) |
| Zach Metsa | 7/1/2025 | D | Signed (The Buffalo Sabres signed D Zach Metsa to a two-way contract.) |
| Carson Meyer | 7/1/2025 | RW | Signed (The Buffalo Sabres signed F Carson Meyer to a two-way contract.) |
| Ryan McLeod | 7/1/2025 | C | Re-Signed (The Buffalo Sabres re-signed F Ryan McLeod.) |
| Justin Danforth | 7/1/2025 | RW | Signed (The Buffalo Sabres signed F Justin Danforth.) |
| Alex Lyon | 7/1/2025 | G | Signed (The Buffalo Sabres signed G Alex Lyon.) |
| Tyson Kozak | 7/1/2025 | C | Signed (The Buffalo Sabres signed F Tyson Kozak to a standard contract.) |
| Ryan Johnson | 7/1/2025 | D | Signed (The Buffalo Sabres signed D Ryan Johnson.) |
| Sam Lafferty | 7/1/2025 | C | Traded (The Buffalo Sabres traded F Sam Lafferty to the Chicago Blackhawks.) To Chicago |
| Felix Sandstrom | 6/30/2025 | G | Became Unrestricted Free Agent (G Felix Sandstrom elected free agency.) |
| Jacob Bernard-Docker | 6/30/2025 | D | Became Unrestricted Free Agent (D Jacob Bernard-Docker elected free agency.) |
| Bennett MacArthur | 6/30/2025 | LW | Became Unrestricted Free Agent (F Bennett MacArthur elected free agency.) |
| James Reimer | 6/30/2025 | G | Became Unrestricted Free Agent (G James Reimer elected free agency.) |
| Ryan Rucinski | 6/28/2025 | C | Drafted (The Buffalo Sabres drafted F Ryan Rucinski) |
| Yevgeni Prokhorov | 6/28/2025 | G | Drafted (The Buffalo Sabres drafted G Yevgeni Prokhorov) |
| Ashton Schultz | 6/28/2025 | C | Drafted (The Buffalo Sabres drafted Ashton Schultz) |
| Melvin Novotny | 6/28/2025 | LW | Drafted (The Buffalo Sabres drafted F Melvin Novotny) |
| Samuel Meloche | 6/28/2025 | G | Drafted (The Buffalo Sabres drafted G Samuel Meloche) |
| Noah Laberge | 6/28/2025 | D | Drafted (The Buffalo Sabres drafted D Noah Laberge.) |
| Matous Kucharcik | 6/28/2025 | C | Drafted (The Buffalo Sabres drafted F Matous Kucharcik) |
| David Bedkowski | 6/28/2025 | D | Drafted (The Buffalo Sabres drafted D David Bedkowski.) |
| Connor Clifton | 6/28/2025 | D | Traded (The Buffalo Sabres traded D Connor Clifton to the Pittsburgh Penguins) To Pittsburgh |
| Conor Timmins | 6/28/2025 | D | Traded (The Pittsburgh Penguins traded D Conor Timmins to the Buffalo Sabres.) From Pittsburgh |
| Isaac Belliveau | 6/28/2025 | D | Traded (The Pittsburgh Penguins traded D Isaac Belliveau to the Buffalo Sabres.) From Pittsburgh |
| Jack Quinn | 6/27/2025 | RW | Signed (The Buffalo Sabres signed F Jack Quinn.) |
| Radim Mrtka | 6/27/2025 | D | Drafted (The Buffalo Sabres drafted D Radim Mrtka.) |
| Josh Doan | 6/25/2025 | RW | Traded (The Utah Mammoth traded F Josh Doan to the Buffalo Sabres.) From Utah |
| Michael Kesselring | 6/25/2025 | D | Traded (The Utah Mammoth traded D Michael Kesselring to the Buffalo Sabres.) From Utah |
| JJ Peterka | 6/25/2025 | RW | Traded (The Buffalo Sabres traded F JJ Peterka to the Utah Mammoth.) To Utah |
