| C | Out (Kozak did not return to Friday's (Oct. 24) game against the Maple Leafs.) | 10/24 |
| D | Out (Bryson did not play in for Friday's (Oct. 24) game against Toronto.) | 10/18 |
| RW | Injured Reserve (The Buffalo Sabres placed F Justin Danforth on Injured Reserve on Saturday (Oct. 18).) | 10/15 |
| C | Injured Reserve (The Buffalo Sabres said on Monday (Oct. 13) that Norris will likely be sidelined for around eight weeks, per Bill Hoppe of the Olean Times Herald.) | 10/9 |
| D | Injured Reserve (The Sabres said on Friday (Oct. 24) that Kesselring could return to play by next week.) | 10/3 |
| LW | Injured Reserve (The Sabres said on Friday (Oct. 24) that Greenway is doing better, but has no time frame yet.) | 9/17 |
| RW | Injured Reserve (The Buffalo Sabres placed F Carson Meyer on injured reserve on Monday (Oct. 6).) | 3/12 |
