Our theoretical and computational work is designed to integrate and abstract rapidly accumulating heterogeneous datasets, to propose critical tests of multiscale regulatory mechanisms, and to guide our own genetic and imaging experiments. Our research is organized around three main themes: the mechanistic modeling of pattern formation and morphogenesis; the synthesis and decomposition of developmental trajectories; and the modeling of human developmental defects. Current projects focus on small cell clusters (motivated by our work on early embryos and animal germline development), graph dynamics in rearranging cell networks (motivated by problems of epithelial morphogenesis), and the effects of activating mutations in signaling enzymes (motivated by our work on a large class of human developmental abnormalities).
Developmental Dynamics Lab
During development, highly ordered structures emerge as cells collectively coordinate with each other. While recent advances have clarified how individual…
PRX LifeThe formation and maintenance of the finite mammalian ovarian reserve are critical for fertility and species survival. Genetic and developmental…
Annual Review of GeneticsSignaling pathways induce stereotyped transcriptional changes as stem cells progress into mature cell types during embryogenesis. Signaling perturbations are necessary…
Developmental Biology
