Analysis of two large pan-cancer datasets highlights ancestry-specific differences in somatic alterations. These data argue for a more ancestry-sensitive approach to personalized medicine for patients with cancer.

The authors use spatial and single-cell transcriptomics to examine spatial dynamics during early human cardiogenesis, yielding insights into the development of the cardiac pacemaker-conduction system, autonomic innervation, heart valves and atrial septum, and heterogeneity of cardiac mesenchymal cells.

This study presents a splice-based selection method that enriches actively editing cells in base editing screening at target loci, reducing the number of unedited cells from over 40% to less than 10%.

Comparative analyses of rice centromeres from 70 high-quality genomes of the Oryza AA group provide insights into rice centromere evolution and genetic factors that shape these genomic regions.

Genomic, transcriptomic and metabolomic analyses from a population of 295 diverse sweet-corn inbred lines provide insights into kernel quality formation mechanisms and the divergence of sweet corn and field corn.

Targeting TGFBR1 in transplantable mouse colorectal tumor organoids improves response to anti-PD-L1 therapy. Mechanistically, TGF-β abrogates clonal expansion of T effector and memory phenotypes and indirectly inhibits T cell activity by regulating immunosuppressive tumor-associated macrophage activity.

Genome-wide CRISPRi screens for modulators of androgen receptor (AR) protein levels using live-cell quantitative endogenous AR fluorescence reporters identify PTGES3 as a new regulator of AR stability and function in prostate cancer.

This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.

Multi-ancestry genome-wide association meta-analyses of polycystic ovary syndrome in women of East Asian and European ancestries identify 94 independent susceptibility regions, including 73 novel loci.

Genome-wide analyses of 10 educational fields identify 17 associated loci. Analysis of genetic clustering across specializations identifies two key dimensions that show genetic overlap with personality traits, behavioral traits and socioeconomic status.

Nature Genetics has joined forces with Nature Communications, Communications Biology and Scientific Reports to create a Collection of papers on 3D genome organization. We reflect on the field and invite submissions addressing fundamental unsolved questions.

Gene implication methods (GIMs) are crucial tools for analyzing genome-wide association studies, but are often ambiguous. We present the LocusCompare2 platform to incorporate six popular GIMs and hundreds of quantitative trait loci datasets, enabling validation across several GIMs and window settings to improve accuracy and reproducibility.