Nature Genetics Nature Genetics is the primary research journal for the genetics community. With a reputation for quality global coverage, Nature Genetics delivers the latest research across the field, including human genetics and genomics, genomics in plant and animal breeding, epigenetics, cancer and genetic technology. With News and Views, Analysis, Perspectives, Letters, Articles and Technical Reports, Nature Genetics is consistently the most frequently cited primary research journal in the field of Genetics and Heredity. http://feeds.nature.com/ng/rss/current Nature Publishing Group en © 2025 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Genetics © 2025 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. [email protected]
  • Nature Genetics https://www.nature.com/uploads/product/ng/rss.png http://feeds.nature.com/ng/rss/current <![CDATA[Author Correction: Prioritizing effector genes at trait-associated loci using multimodal evidence]]> https://www.nature.com/articles/s41588-025-02416-7 <![CDATA[
    See More

    Nature Genetics, Published online: 27 October 2025; doi:10.1038/s41588-025-02416-7

    Author Correction: Prioritizing effector genes at trait-associated loci using multimodal evidence]]> <![CDATA[Author Correction: Prioritizing effector genes at trait-associated loci using multimodal evidence]]> Marijn SchipperChristiaan A. de LeeuwBernardo A. P. C. MacielDouglas P. WightmanNikki HubersDorret I. BoomsmaMichael C. O’DonovanDanielle Posthuma doi:10.1038/s41588-025-02416-7 Nature Genetics, Published online: 2025-10-27; | doi:10.1038/s41588-025-02416-7 2025-10-27 Nature Genetics 10.1038/s41588-025-02416-7 https://www.nature.com/articles/s41588-025-02416-7 <![CDATA[OTX2 awakens the genome of human embryos]]> https://www.nature.com/articles/s41588-025-02254-7 <![CDATA[

    Nature Genetics, Published online: 27 October 2025; doi:10.1038/s41588-025-02254-7

    The transcription factors responsible for initiating embryonic genome activation (EGA) in humans remain largely unknown. A study now characterizes the role of the maternal factor OTX2 in kickstarting human EGA.]]>     <![CDATA[OTX2 awakens the genome of human embryos]]> Sergio Ruiz doi:10.1038/s41588-025-02254-7 Nature Genetics, Published online: 2025-10-27; | doi:10.1038/s41588-025-02254-7 2025-10-27 Nature Genetics 10.1038/s41588-025-02254-7 https://www.nature.com/articles/s41588-025-02254-7     <![CDATA[Mitigating inconsistencies in GWAS follow-up analyses with LocusCompare2]]> https://www.nature.com/articles/s41588-025-02331-x <![CDATA[

    Nature Genetics, Published online: 27 October 2025; doi:10.1038/s41588-025-02331-x

    Gene implication methods (GIMs) are crucial tools for analyzing genome-wide association studies, but are often ambiguous. We present the LocusCompare2 platform to incorporate six popular GIMs and hundreds of quantitative trait loci datasets, enabling validation across several GIMs and window settings to improve accuracy and reproducibility.]]>     <![CDATA[Mitigating inconsistencies in GWAS follow-up analyses with LocusCompare2]]> Fei LiuJunbin GaoYi LinHaiyue MengWei WangYujiao LuoYuan CaoWenjing WangFei GuanPeizhe WangJin TangHae Kyung ImXiaoquan WenBoxiang Liu doi:10.1038/s41588-025-02331-x Nature Genetics, Published online: 2025-10-27; | doi:10.1038/s41588-025-02331-x 2025-10-27 Nature Genetics 10.1038/s41588-025-02331-x https://www.nature.com/articles/s41588-025-02331-x     <![CDATA[A pangenome of maize provides genetic insights into drought resistance]]> https://www.nature.com/articles/s41588-025-02378-w <![CDATA[

    Nature Genetics, Published online: 27 October 2025; doi:10.1038/s41588-025-02378-w

    This study presents 25 new maize genome assemblies and integrates them with 31 publicly available maize genomes to conduct a pangenome analysis that provides genetic insights into drought resistance.]]>     <![CDATA[A pangenome of maize provides genetic insights into drought resistance]]> Shiping YangYijie WangQin HuangMengyuan WangShuhui WangXiaomeng FuChaohui ZhuJinkui ChengShengxue LiuZhirui YangNing YangJianbing YanXiaohong YangFeng Qin doi:10.1038/s41588-025-02378-w Nature Genetics, Published online: 2025-10-27; | doi:10.1038/s41588-025-02378-w 2025-10-27 Nature Genetics 10.1038/s41588-025-02378-w https://www.nature.com/articles/s41588-025-02378-w     <![CDATA[Cellular states associated with metastatic organotropism and survival in patients with pancreatic ductal adenocarcinoma]]> https://www.nature.com/articles/s41588-025-02345-5 <![CDATA[

    Nature Genetics, Published online: 27 October 2025; doi:10.1038/s41588-025-02345-5

    Integrated clinical and single-cell analysis of primary pancreatic tumor samples that later recur in the liver or lung shows that tumor cells at the primary site transcriptionally resemble the normal parenchymal epithelia of the liver or lung, respectively.]]>     <![CDATA[Cellular states associated with metastatic organotropism and survival in patients with pancreatic ductal adenocarcinoma]]> Morteza Chalabi HajkarimMichael MayAmit Dipak AminJacob JamisonSomnath TagoreEdridge D’SouzaLindsay CaprioZachary H. WalshJoy Linyue FanMingxuan ZhangParin ShahSinan AbuzaidAlissa MichelSun DajiangWinston WongNeha ShaikhPriyanka RamaradjBasil BakirMichael D. KlugerJohn ChabotElham AziziHanina HibshooshAnil K. RustgiAlexander G. RaufiGulam A. ManjiBenjamin Izar doi:10.1038/s41588-025-02345-5 Nature Genetics, Published online: 2025-10-27; | doi:10.1038/s41588-025-02345-5 2025-10-27 Nature Genetics 10.1038/s41588-025-02345-5 https://www.nature.com/articles/s41588-025-02345-5     <![CDATA[Maternal factor OTX2 regulates human embryonic genome activation and early development]]> https://www.nature.com/articles/s41588-025-02350-8 <![CDATA[

    Nature Genetics, Published online: 27 October 2025; doi:10.1038/s41588-025-02350-8

    OTX2 binds to and activates genes involved in embryonic genome activation, including TPRX1 and TPRX2. OTX2 knockdown impairs embryonic genome activation and early development, which can be partially rescued by overexpression of TPRX1 and TPRX2.]]>     <![CDATA[Maternal factor OTX2 regulates human embryonic genome activation and early development]]> Qiuyan WangChuanxin ZhangYanna DangJiaqi SunZhuoning ZouCheng LiShuiying MaZongyu LiHui LiuXiaonan MaZhen YangLijuan WangKeliang WuZi-Jiang ChenWei XieHan Zhao doi:10.1038/s41588-025-02350-8 Nature Genetics, Published online: 2025-10-27; | doi:10.1038/s41588-025-02350-8 2025-10-27 Nature Genetics 10.1038/s41588-025-02350-8 https://www.nature.com/articles/s41588-025-02350-8     <![CDATA[Author Correction: An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer]]> https://www.nature.com/articles/s41588-025-02394-w <![CDATA[

    Nature Genetics, Published online: 22 October 2025; doi:10.1038/s41588-025-02394-w

    Author Correction: An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer]]>     <![CDATA[Author Correction: An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer]]> Ming ChenJiangwen ZhangKatia SampieriJohn G. ClohessyLourdes MendezEnrique Gonzalez-BillalabeitiaXue-Song LiuYu-Ru LeeJacqueline FungJesse M. KatonArchita Venugopal MenonKaitlyn A. WebsterChristopher NgMaria Dilia PalumbieriMoussa S. DiolombiSusanne B. BreitkopfJulie Teruya-FeldsteinSabina SignorettiRoderick T. BronsonJohn M. AsaraMireia Castillo-MartinCarlos Cordon-CardoPier Paolo Pandolfi doi:10.1038/s41588-025-02394-w Nature Genetics, Published online: 2025-10-22; | doi:10.1038/s41588-025-02394-w 2025-10-22 Nature Genetics 10.1038/s41588-025-02394-w https://www.nature.com/articles/s41588-025-02394-w     <![CDATA[Pathogenic <i>UNC13A</i> variants cause a neurodevelopmental syndrome by impairing synaptic function]]> https://www.nature.com/articles/s41588-025-02361-5 <![CDATA[

    Nature Genetics, Published online: 22 October 2025; doi:10.1038/s41588-025-02361-5

    Pathogenic variants in UNC13A underlie a novel neurodevelopmental syndrome, with three subtypes defined by distinct genotypes with varying clinical and functional impacts characterized in cellular and animal models.]]>     <![CDATA[Pathogenic <i>UNC13A</i> variants cause a neurodevelopmental syndrome by impairing synaptic function]]> Reza AsadollahiAisha AhmadParanchai BoonsawatJasmine Shahanoor HinzenMareike LohseBoris Bouazza-ArosteguiSiqi SunTillmann UteschJonas D. SommerDragana IlicMurugesh PadmanarayanaKati FischermannsMrinalini RanjanMoritz BollChandran KaAmélie PitonFrancesca MattioliBertrand IsidorKatrin ÕunapKarit ReinsonMonica H. WojcikChristian R. MarshallSaadet Mercimek-AndrewsNaomichi MatsumotoNoriko MiyakeBruno de Oliveira StephanRachel Sayuri HonjoDebora R. BertolaChong Ae KimRoman YusupovHeather C. MeffordJohn ChristodoulouJoy LeeOliver HeathNatasha J. BrownNaomi BakerZornitza StarkMartin DelatyckiNicole J. LakeShimriet ZeidlerLinda ZuurbierSaskia M. MaasChris C. de KruiffFarrah RajabiLance H. RodanStephanie A. CouryKonrad PlatzerHenry OppermannRami Abou JamraSkadi BebloCaroline MaxtonRobert ŚmigielHunter UnderhillHolly DubbsAlyssa RosenKatherine L. HelbigIngo HelbigSarah McKeown RuggieroMark P. FitzgeraldDennis KraemerCarlos E. PradaJeffrey TenneyParul JayakarSylvia RedonJérémie LefrancKevin UguenSimone RaceStephanie EfthymiouReza MaroofianHenry HouldenSandra CoppensNicolas DeconinckBalasubramaniem AshokkumarPerumal VaralakshmiVykunta Raju Gowda KFatemeh EghbalEhsan Ghayoor KarimianiMorteza HeidariJohn NeidhardtMarta Owczarek-LipskaG. Christoph KorenkeMichael J. BamshadPhilippe M. CampeauAnna LehmanLaura G. HendonIngrid M. WentzensenKristin G. MonaghanYanmin ChenAnna SzutoRonald D. CohnPing Yee Billie AuChristoph HübnerFelix BoschannKandamurugu ManickamDaniel C. KoboldtAboulfazl RadGabriela OpreaKristine K. BachmanAndrea H. SeeleyEmanuele AgoliniAlessandra TerraccianoPiscopo CarmeloCaleb BuppBethany GryskoAnnick Rein-RothschildBruria Ben ZeevAmy MargolinJennifer MorrisonAditi DagliElliot StolermanRaymond J. LouieCamerun WashingtonServi J. C. StevensMalou HeijligersFowzan S. AlkurayaJasmin LisfeldAxel NeuFabíola Paoli MonteiroAndré Luiz Santos PessoaAntonio Edvan Camelo-FilhoFernando KokDwight KoeberlKacie RileyLydie BurglenDiane DoummarBénédicte HéronCyril MignotBoris KerenPerrine CharlesCaroline NavaFelix P. BernhardAndrea A. KühnSven ThomsRyan D. MorrieShila MekhoubadEric M. GreenSami J. BarmadaAaron D. GitlerOlaf JahnJeong Seop RheeChristian RosenmundMišo MitkovskiHeinrich StichtHan SunGerald Le GacHolger TaschenbergerNils BroseJeremy S. DittmanAnita RauchNoa Lipstein doi:10.1038/s41588-025-02361-5 Nature Genetics, Published online: 2025-10-22; | doi:10.1038/s41588-025-02361-5 2025-10-22 Nature Genetics 10.1038/s41588-025-02361-5 https://www.nature.com/articles/s41588-025-02361-5