Extended Data Fig. 9: Cross-trait comparisons of gene effects, related to Fig. 5.
From: Causal modelling of gene effects from regulators to programs to traits
a) Comparison of LoF burden test effect sizes after GeneBayes between IRF and RDW. The solid line corresponds to the first principal component. b) Cross-trait directional relationships of gene effects in the predicted gene-to-program-to-trait model and raw data from the LoF burden test. The left table shows the comparison between MCH and RDW, while the right table shows the comparison between RDW and IRF. For each table, only genes that have strong effects in both traits (|γ| > 0.1) and selected in the predicted model for both traits are considered. For instance, +1 means that the gene has strong effects for both traits in the same direction. MCH and IRF share few genes with strong effects and could not be compared. c) Correlation of regulatory effects on four programs or Shet with γ. For each trait, correlation coefficients were estimated with the multiple regression model. Error bars indicate 95% CI.
