Nature, Published online: 08 November 2025; doi:10.1038/d41586-025-03380-2
The co-discoverer of the structure of DNA helped to strengthen a US research institute and wrote a classic textbook, but also earned a reputation for racist and sexist comments.]]>Nature, Published online: 07 November 2025; doi:10.1038/d41586-025-03665-6
First image from Vera C. Rubin telescope reveals a previously unnoticed feature of galaxy M61 that may explain its mysterious properties.]]>Nature, Published online: 07 November 2025; doi:10.1038/d41586-025-03518-2
Dimming of the starlight from RZ Piscium reveals that 24 unseen bodies are whizzing around the star.]]>Nature, Published online: 07 November 2025; doi:10.1038/d41586-025-03664-7
The repository is taking steps to tackle a surge in low quality, AI-generated content.]]>Nature, Published online: 07 November 2025; doi:10.1038/d41586-025-03623-2
Researchers feel that pressures to publish are increasing, but the time and resources available to do research are decreasing, according to a survey by Elsevier.]]>Nature, Published online: 07 November 2025; doi:10.1038/d41586-025-03600-9
A life well lived.]]>Nature, Published online: 07 November 2025; doi:10.1038/d41586-025-03485-8
Vicarious trauma is an occupational risk for some researchers. But there are strategies to cope.]]>Nature, Published online: 07 November 2025; doi:10.1038/d41586-025-03653-w
Trend flies in face of Trump-administration policies, but could yet see a rapid decrease, especially in science fields.]]>Nature, Published online: 06 November 2025; doi:10.1038/s41586-025-09817-y
Author Correction: The emergence of transcriptional identity in somatosensory neurons]]>Nature, Published online: 06 November 2025; doi:10.1038/s41586-025-09789-z
Author Correction: TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2]]>Nature, Published online: 06 November 2025; doi:10.1038/s41586-025-09832-z
An ATP-gated molecular switch orchestrates human messenger RNA export]]>Nature, Published online: 06 November 2025; doi:10.1038/d41586-025-03399-5
Sociologist Patricia Kingori is helping to expose contract cheating by scholars in high-income countries.]]>Nature, Published online: 06 November 2025; doi:10.1038/d41586-025-03626-z
A high-resolution digital map nearly doubles the known length of the ancient road network.]]>Nature, Published online: 06 November 2025; doi:10.1038/d41586-025-03641-0
A collection of studies that chart how mammalian brain cells grow and differentiate is a ‘very valuable’ tool for neuroscientists.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09830-1
Myriad Aryne Derivatives from Carboxylic Acids]]>Nature, Published online: 05 November 2025; doi:10.1038/d41586-025-03642-z
Growth rings in fossilized bones suggest the diminutive dinosaur, Nanotyrannus, would never grow up to become a T. rex — plus, a small breast cancer prevention trial shows promise.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09665-w
A multipass optical parametric amplifier leverages dispersion-engineered dielectric mirrors to overcome the gain versus bandwidth trade-off and achieve broadband amplification with high gain within a compact device.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09710-8
The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung adenocarcinoma, suggesting its potential as a therapeutic target in lung cancer.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09718-0
Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lunapark protein and is modulated by nutrient status.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09567-x
A method using subtree pruning and regrafting-based tree assessment (SPRTA), which considers evolutionary relationships between lineages, enhances interpretability of phylogenetic analyses such as those of SARS-CoV-2 variants.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09706-4
Vector-stimuli-responsive magnetorheological fibrous materials can be mass-produced, which can be assembled into yarns and woven into a variety of fabrics with actuation and stiffening abilities.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09652-1
Recent studies integrating multi-omics data with cell atlases across development for brains of humans and model organisms are revealing conserved and divergent patterns of brain development at the molecular and cellular levels, and linking these to complex behavioural and neuropsychiatric phenotypes.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09709-1
Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09716-2
The Fair Human-Centric Image Benchmark (FHIBE, pronounced ‘Feebee’)—an image dataset that implements best practices for consent, privacy, compensation, safety, diversity and utility—can be used responsibly as a fairness evaluation dataset for many human-centric computer vision applications.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09683-8
High-resolution satellites reveal major uncertainties in methane emissions from global waste sites, highlighting the need to reconcile observed and reported data, with actionable insights to improve estimates and guide targeted mitigation efforts.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09698-1
Synthetic fibril strain 1B is a pathogen that is capable of self-replication and inducing glial cytoplasmic inclusions in vivo in mice, and the structural features of 1B may underlie the pathology of individuals with multiple-system atrophy.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09662-z
PU.1low CD28-expressing microglia may act as suppressive cells in Alzheimer’s disease, mitigating its progression by reducing neuroinflammation and amyloid plaque load, indicating potential immunotherapeutic approaches for treatment.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09721-5
The combination of computational design, laboratory-based screening and biophysical validation enables the de novo generation of variable heavy-chain antibody fragments and antibodies that precisely target chosen disease-related molecules.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09033-8
Lineage tracing in human tissue samples from gestational weeks 16 to 24 provides insight into lineage relationships between cortical cell types and shows a switch in progenitor output from glutamatergic to GABAergic neurons.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09644-1
A high-resolution transcriptomic and epigenomic cell-type atlas of the developing mouse visual cortex from embryonic to postnatal development is presented, providing a real-time dynamic molecular map associated with individual cell types and specific developmental events.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09677-6
Structures of GDP-bound MOR–Gi conformational states combined with pharmacological assays show an inverse correlation between ligand efficacy and GDP affinity, where agonists decrease GDP affinity, promoting GTP exchange, and antagonists increase GDP affinity, dampening activation, thus providing structural and mechanistic insights into G protein activation.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09592-w
An analysis of cell-type diversity in brain samples from a variety of mammalian species, both during development and in adult animals, reveals that the TAC3 initial class of striatal interneurons is conserved across placental mammals and is homologous to Th striatal interneurons in rodents.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09696-3
An investigation of plant receptor-like kinases identifies regions of these proteins that control whether immune or symbiotic signalling pathways are activated, with minimal changes to specific residues in one of these regions being sufficient to alter signalling specificity.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09731-3
A previously unsampled deep lineage in central Argentina was discovered that had distinctive genetic drift by 8,500 bp and persisted as the main Native American ancestry component in the region up to the present day.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09684-7
Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing epithelial–stromal remodelling and suppression of luminal progenitors.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09708-2
NextBrain is an open source, probabilistic atlas of the entire human brain, assembled using artificial-intelligence-enabled registration and segmentation methods to reconstruct the multimodal serial histology of five human half brains, and which can be used to automatically segment brain MRI scans into 333 regions.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09663-y
A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09668-7
Seismic data from the Turkana Depression in East Africa show that areas of thinned lithosphere are not necessarily persistent weak zones where extension and magmatic provinces will develop.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09703-7
Genetic association tests prioritize candidate genes based on different criteria.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09687-4
A materials platform using tantalum as a base layer and silicon as the substrate to construct superconducting qubits enables device performance improvements such as millisecond lifetimes and coherence times, as well as high time-averaged quality factors.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09296-1
Long-distance migration and dispersion is a common characteristic of nearly all classes of telencephalic GABAergic neurons, which diversify extensively after birth in the cortex and striatum, but show limited postnatal changes in the septum, preoptic area and pallidum.]]>Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09755-9
Adenosine signalling is identified as the central mechanism of action of the antidepressant effects of ketamine and electroconvulsive therapy, and newly developed analogues of ketamine exhibit improved antidepressant efficacy with reduced side effects.]]>Nature, Published online: 05 November 2025; doi:10.1038/d41586-025-03540-4
Scientists are developing antibodies to track the evolution of these viruses and better treat infections.]]>Nature, Published online: 05 November 2025; doi:10.1038/d41586-025-03265-4
Parting gifts.]]>Nature, Published online: 05 November 2025; doi:10.1038/d41586-025-03449-y
It is challenging to generate ultrashort laser pulses at high powers, but repeatedly overlapping light pulses in a crystal can efficiently amplify a weak signal.]]>Nature, Published online: 05 November 2025; doi:10.1038/d41586-025-03654-9
Failures to scale and retain the economic benefits of research in the United Kingdom are killing the country’s science sector, say lawmakers. Plus, how AI might influence how we define creativity and the biggest black-hole outburst ever seen.]]>Nature, Published online: 05 November 2025; doi:10.1038/d41586-025-03617-0
Although China needs to strengthen its leadership in artificial intelligence, semiconductors and energy, say researchers.]]>Nature, Published online: 05 November 2025; doi:10.1038/d41586-025-03581-9
The time points beyond which individual Antarctic ice shelves could no longer exist in their current form have been estimated under several anthropogenic emission scenarios. These projections take into account uncertainties related to ice, atmosphere and ocean processes, including those concerning poorly understood processes such as ice fracturing and iceberg formation.]]>Nature, Published online: 05 November 2025; doi:10.1038/d41586-025-03624-1
A non-invasive imaging technique can translate scenes in your head into sentences. It could help to reveal how the brain interprets the world.]]>Nature, Published online: 05 November 2025; doi:10.1038/d41586-025-03568-6
A high-quality image data set shows that tech companies can obtain informed consent and avoid data bias without breaking the bank.]]>Nature, Published online: 05 November 2025; doi:10.1038/d41586-025-03570-y
Chatbots and AI models are challenging ideas about who — or what — can create art, music and more.]]>Nature, Published online: 05 November 2025; doi:10.1038/d41586-025-03450-5
A large consortium of researchers has mapped how brain cells establish diverse identities throughout neurodevelopment and across species.]]>Nature, Published online: 04 November 2025; doi:10.1038/d41586-025-03559-7
Safeguards for virology must be designed in partnership with the public]]>Nature, Published online: 04 November 2025; doi:10.1038/d41586-025-03616-1
When will Africa have a Nobel prize in medicine?]]>Nature, Published online: 04 November 2025; doi:10.1038/d41586-025-03614-3
Can AI predict and limit online hate?]]>Nature, Published online: 04 November 2025; doi:10.1038/d41586-025-03615-2
China should undertake more risky research to close the Nobel gap]]>Nature, Published online: 04 November 2025; doi:10.1038/d41586-025-03516-4
Footage from a lone camera incidentally located metres from a fault provides data on slippage duration and motion.]]>Nature, Published online: 04 November 2025; doi:10.1038/d41586-025-03455-0
Crop prices correlate with an 11-year solar period, and a meteor detonates over Ireland, in this week’s pick from the Nature archive.]]>Nature, Published online: 04 November 2025; doi:10.1038/d41586-025-03597-1
A ‘superflare’ 10 trillion times brighter than the Sun is confirmed as the record-holder for luminosity.]]>Nature, Published online: 04 November 2025; doi:10.1038/d41586-025-03569-5
Sanae Takaichi has pledged to make the country ‘strong and prosperous’ again; success hinges on breaking barriers for women in science.]]>Nature, Published online: 04 November 2025; doi:10.1038/d41586-025-03567-7
Delegates to the climate conference in Brazil must accelerate commitments to rapidly developing a low-carbon economy. There is no Planet B.]]>Nature, Published online: 04 November 2025; doi:10.1038/d41586-025-03560-0
Extreme weather threatens the extraction of critical minerals required to produce clean energy.]]>Nature, Published online: 04 November 2025; doi:10.1038/d41586-025-03574-8
A focus on national security alone is limiting people’s access to key materials.]]>Nature, Published online: 04 November 2025; doi:10.1038/d41586-025-03412-x
Limited COVID-19 surveillance data are hampering vaccination and health strategies, researchers say.]]>Nature, Published online: 04 November 2025; doi:10.1038/d41586-025-03627-y
How the world can fight climate change without the help of the United States. Plus, the benefits of walks long and short and whether attitudes to controversial ‘CRISPR babies’ are changing.]]>Nature, Published online: 04 November 2025; doi:10.1038/d41586-025-03323-x
A course on disruptive innovation, and a supportive professional network, helped to unleash João Paulo Longo’s entrepreneurship skills.]]>Nature, Published online: 03 November 2025; doi:10.1038/s41586-025-09815-0
Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome]]>Nature, Published online: 03 November 2025; doi:10.1038/s41586-025-09813-2
Accelerating the discovery of multicatalytic cooperativity]]>Nature, Published online: 03 November 2025; doi:10.1038/d41586-025-03576-6
Charlene Yeong works as a veterinarian with animals from zoos and those native to Singapore.]]>Nature, Published online: 03 November 2025; doi:10.1038/d41586-025-03573-9
A thoroughly researched account of the history and relationships that shaped the scientist who co-discovered the structure of DNA.]]>Nature, Published online: 03 November 2025; doi:10.1038/d41586-025-03571-x
With the US government absent from the COP30 global climate summit, it will be up to others to avert catastrophe.]]>Nature, Published online: 03 November 2025; doi:10.1038/d41586-025-03619-y
Researchers are preparing to trial the personalized base-editing therapy that saved a baby boy last year in at least five more children. Plus, get to know the real Francis Crick and what tree rings reveal about ancient coffins.]]>Nature, Published online: 03 November 2025; doi:10.1038/d41586-025-03572-w
As machines get better at data analysis and writing tasks, doctoral training must evolve to make the most of artificial-intelligence outputs.]]>Nature, Published online: 03 November 2025; doi:10.1038/d41586-025-03596-2
A modest increase in physical activity can delay cognitive decline by three years — or more.]]>Nature, Published online: 03 November 2025; doi:10.1038/d41586-025-03575-7
From NASA to the National Institutes of Health, federal agencies conduct research that universities cannot. Agency scientists speak out about the irreplaceable facilities, institutional knowledge and training opportunities that the country is losing.]]>