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  • RESEARCH BRIEFINGS

Blood cancer driven by ‘one hit’ mutation event undergoes rapid growth

Reconstructions of the ‘evolutionary’ relationships among blood-cell clones from individuals with the blood cancer chronic myeloid leukaemia reveal that the cancer clone grows exceptionally quickly, reaching rates of between 10,000% and 1,000,000% per year. This variability in growth rate could explain differences in responses to cancer treatments.

This is a summary of: Kamizela, A. E. et al. Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia. Nature 640, 982–990 (2025).

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doi: https://doi.org/10.1038/d41586-025-01170-4

‘Expert opinion’ and the figure are published under a CC BY 4.0 licence.

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