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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes Human disease related genes Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
22
Cytoband
q12.1
Chromosome location (bp)
28687743 - 28742422
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] 1. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition 2. Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly 3....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Cancers of soft tissues and bone Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000077[DNA damage checkpoint signaling] GO:0000086[G2/M transition of mitotic cell cycle] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006281[DNA repair] GO:0006302[double-strand break repair] GO:0006355[regulation of DNA-templated transcription] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049[cell cycle] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016605[PML body] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0030163[protein catabolic process] GO:0031573[mitotic intra-S DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0042176[regulation of protein catabolic process] GO:0042770[signal transduction in response to DNA damage] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0044773[mitotic DNA damage checkpoint signaling] GO:0045893[positive regulation of DNA-templated transcription] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0050821[protein stabilization] GO:0051301[cell division] GO:0090307[mitotic spindle assembly] GO:0090399[replicative senescence] GO:0106310[protein serine kinase activity] GO:1901796[regulation of signal transduction by p53 class mediator]
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Cancers of soft tissues and bone Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000077[DNA damage checkpoint signaling] GO:0000086[G2/M transition of mitotic cell cycle] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006281[DNA repair] GO:0006302[double-strand break repair] GO:0006355[regulation of DNA-templated transcription] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049[cell cycle] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016605[PML body] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0030163[protein catabolic process] GO:0031573[mitotic intra-S DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0042176[regulation of protein catabolic process] GO:0042770[signal transduction in response to DNA damage] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0044773[mitotic DNA damage checkpoint signaling] GO:0045893[positive regulation of DNA-templated transcription] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0050821[protein stabilization] GO:0051301[cell division] GO:0090307[mitotic spindle assembly] GO:0090399[replicative senescence] GO:0106310[protein serine kinase activity] GO:1901796[regulation of signal transduction by p53 class mediator]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of soft tissues and bone Other diseases Others Protein evidence (Ezkurdia et al 2014)
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of soft tissues and bone Other diseases Others Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Cancers of soft tissues and bone Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000077[DNA damage checkpoint signaling] GO:0000086[G2/M transition of mitotic cell cycle] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006281[DNA repair] GO:0006302[double-strand break repair] GO:0006355[regulation of DNA-templated transcription] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049[cell cycle] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016605[PML body] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0030163[protein catabolic process] GO:0031573[mitotic intra-S DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0042176[regulation of protein catabolic process] GO:0042770[signal transduction in response to DNA damage] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0044773[mitotic DNA damage checkpoint signaling] GO:0045893[positive regulation of DNA-templated transcription] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0050821[protein stabilization] GO:0051301[cell division] GO:0090307[mitotic spindle assembly] GO:0090399[replicative senescence] GO:0106310[protein serine kinase activity] GO:1901796[regulation of signal transduction by p53 class mediator]
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Cancers of soft tissues and bone Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000077[DNA damage checkpoint signaling] GO:0000086[G2/M transition of mitotic cell cycle] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0001934[positive regulation of protein phosphorylation] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006281[DNA repair] GO:0006302[double-strand break repair] GO:0006355[regulation of DNA-templated transcription] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0007049[cell cycle] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010332[response to gamma radiation] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016605[PML body] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0019901[protein kinase binding] GO:0030163[protein catabolic process] GO:0031573[mitotic intra-S DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0042176[regulation of protein catabolic process] GO:0042770[signal transduction in response to DNA damage] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0044773[mitotic DNA damage checkpoint signaling] GO:0045893[positive regulation of DNA-templated transcription] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0050821[protein stabilization] GO:0051301[cell division] GO:0070242[thymocyte apoptotic process] GO:0071466[cellular response to xenobiotic stimulus] GO:0071480[cellular response to gamma radiation] GO:0090307[mitotic spindle assembly] GO:0090399[replicative senescence] GO:0106310[protein serine kinase activity] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1903416[response to glycoside] GO:1903926[cellular response to bisphenol A] GO:2000002[negative regulation of DNA damage checkpoint] GO:2000210[positive regulation of anoikis]
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Cancers of soft tissues and bone Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000077[DNA damage checkpoint signaling] GO:0000086[G2/M transition of mitotic cell cycle] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006281[DNA repair] GO:0006302[double-strand break repair] GO:0006355[regulation of DNA-templated transcription] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049[cell cycle] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016605[PML body] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0030163[protein catabolic process] GO:0031573[mitotic intra-S DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0042176[regulation of protein catabolic process] GO:0042770[signal transduction in response to DNA damage] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0044773[mitotic DNA damage checkpoint signaling] GO:0045893[positive regulation of DNA-templated transcription] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0050821[protein stabilization] GO:0051301[cell division] GO:0090307[mitotic spindle assembly] GO:0090399[replicative senescence] GO:0106310[protein serine kinase activity] GO:1901796[regulation of signal transduction by p53 class mediator]
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Cancers of soft tissues and bone Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000077[DNA damage checkpoint signaling] GO:0000086[G2/M transition of mitotic cell cycle] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006281[DNA repair] GO:0006302[double-strand break repair] GO:0006355[regulation of DNA-templated transcription] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049[cell cycle] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016605[PML body] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0030163[protein catabolic process] GO:0031573[mitotic intra-S DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0042176[regulation of protein catabolic process] GO:0042770[signal transduction in response to DNA damage] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0044773[mitotic DNA damage checkpoint signaling] GO:0045893[positive regulation of DNA-templated transcription] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0050821[protein stabilization] GO:0051301[cell division] GO:0090307[mitotic spindle assembly] GO:0090399[replicative senescence] GO:0106310[protein serine kinase activity] GO:1901796[regulation of signal transduction by p53 class mediator]
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of soft tissues and bone Other diseases Others Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of soft tissues and bone Other diseases Others Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of soft tissues and bone Other diseases Others Protein evidence (Ezkurdia et al 2014)
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of soft tissues and bone Other diseases Others Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Cancers of soft tissues and bone Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000077[DNA damage checkpoint signaling] GO:0000086[G2/M transition of mitotic cell cycle] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006281[DNA repair] GO:0006302[double-strand break repair] GO:0006355[regulation of DNA-templated transcription] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049[cell cycle] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016605[PML body] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0030163[protein catabolic process] GO:0031573[mitotic intra-S DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0042176[regulation of protein catabolic process] GO:0042770[signal transduction in response to DNA damage] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0044773[mitotic DNA damage checkpoint signaling] GO:0045893[positive regulation of DNA-templated transcription] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0050821[protein stabilization] GO:0051301[cell division] GO:0090307[mitotic spindle assembly] GO:0090399[replicative senescence] GO:0106310[protein serine kinase activity] GO:1901796[regulation of signal transduction by p53 class mediator]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of soft tissues and bone Other diseases Others Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Cancers of soft tissues and bone Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077[DNA damage checkpoint signaling] GO:0000086[G2/M transition of mitotic cell cycle] GO:0000166[nucleotide binding] GO:0000781[chromosome, telomeric region] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006281[DNA repair] GO:0006302[double-strand break repair] GO:0006355[regulation of DNA-templated transcription] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049[cell cycle] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016605[PML body] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0030163[protein catabolic process] GO:0031573[mitotic intra-S DNA damage checkpoint signaling] GO:0031625[ubiquitin protein ligase binding] GO:0042176[regulation of protein catabolic process] GO:0042770[signal transduction in response to DNA damage] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0044773[mitotic DNA damage checkpoint signaling] GO:0045893[positive regulation of DNA-templated transcription] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0050821[protein stabilization] GO:0051301[cell division] GO:0090307[mitotic spindle assembly] GO:0090399[replicative senescence] GO:0106310[protein serine kinase activity] GO:1901796[regulation of signal transduction by p53 class mediator]
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