News from The Human Protein AtlasThe latest news from the Human Protein Atlas.https://www.proteinatlas.org/newsOptineurin as a key player in GOMEDThe ability to degrade intracellular proteins in a controlled manner is an important cellular function. It is utilized to remove and recycle unnecessary, damaged and/or harmful components, which is an essential ability to maintain cellular homeostasis and health. The most well-known routes to selective degradation of proteins are proteasomal degradation and selective autophagy. In both pathways, proteins targeted for degradation are marked polyubiquitination (polyUb), with chains that are linked at lysine K48 and K63, respectively.https://www.proteinatlas.org/news/2025-10-22/optineurin-as-a-key-player-in-gomedWed, 22 Oct 2025 00:00:00Multiplex tissue image of the month - CYLC1 in testisSperm head structural protein cylicin 1 (gene: CYLC1) is visualized in late stage spermatogenesis with multiplex immunohistochemistry (mIHC/IF).https://www.proteinatlas.org/news/2025-10-15/multiplex-tissue-image-of-the-month-cylc1-in-testisWed, 15 Oct 2025 00:00:00Pan-disease atlas maps molecular fingerprints of health, disease and agingA new study has mapped the distinct molecular "fingerprints" that 59 diseases leave in an individual's blood protein - which would enable blood tests to discern troubling signs from those that are more common. Publishing today in Science, an international team of researchers mapped how thousands of proteins in human blood shift as a result of aging and serious diseases, such as cancer and cardiovascular and autoimmune diseases.https://www.proteinatlas.org/news/2025-10-09/pan-disease-atlas-maps-molecular-fingerprints-of-health-disease-and-agingThu, 9 Oct 2025 00:00:00Voltage-gated ion channels in the spotlight Ion channels are pore-forming membrane proteins that selectively facilitate the rapid, passive movement of specific ions across various cell membranes and play an important role in many of our organ systems. In the Human Protein Atlas, the voltage-gated ion channels are represented by more than 100 genes from nine different subcategories based on their selectivity and the ions they conduct.https://www.proteinatlas.org/news/2025-10-04/voltage-gated-ion-channels-in-the-spotlightSat, 4 Oct 2025 00:00:00Human Protein Atlas study on primary cilia published in CellIn the journal Cell, researchers publish a deep analysis of the HPA primary cilia section, first introduced in HPA v24. The HPA subcellular resource portrays primary cilia as the most heterogeneous organelles, customized by the cell for fine-tuned environmental sensing, and inspires many new views on this tiny antenna.https://www.proteinatlas.org/news/2025-09-25/human-protein-atlas-study-on-primary-cilia-published-in-cellThu, 25 Sep 2025 00:00:00