See More

SNQ2 basal levels of expression are positively regulated by Pdr1p, Pdr3p, and Stb5p, through the binding of these transcription factors to pleiotropic drug response elements (PDREs) present in the SNQ2 promoter (7, 12, 13, and 14). SNQ2 expression is also drug-induced by Yrr1p (15, 16) and heat-shock-induced by the AP-1 transcription factors Yap1p and Cad1p (17).

Snq2p is a member of the ATP-binding cassette (ABC) family of proteins, a large group that are conserved from bacteria to humans (1, 4). Overexpression of the human ABC transporter ABCB1/MDR1 (OMIM) is a factor in tumor resistance to drug therapy, and deficient ABC transporter function has been implicated in other human diseases as well (reviewed in 4). S. cerevisiae ABC proteins are often used as a model to study the clinical problem of drug resistance in infectious disease and cancer as well as in pharmaceutical screens for novel drugs (18 and reviewed in 19).", "date_edited": "2011-01-13"}, "literature_overview": {"primary_count": 76, "additional_count": 142, "review_count": 38, "go_count": 6, "phenotype_count": 8, "disease_count": 0, "interaction_count": 46, "regulation_count": 16, "ptm_count": 12, "funComplement_count": 0, "htp_count": 33, "total_count": 327}, "disease_overview": {"manual_disease_terms": [], "htp_disease_terms": [], "computational_annotation_count": 0, "date_last_reviewed": null}, "ecnumbers": [], "URS_ID": null, "main_strain": "S288C", "regulation_overview": {"regulator_count": 17, "target_count": 0}, "reference_mapping": {"599472": 1, "588911": 2, "555750": 3, "593793": 4, "552527": 5, "587469": 6, "649272": 7, "524983": 8, "634111": 9, "639493": 10, "475668": 11, "642623": 12, "561386": 13, "641147": 14, "599254": 15, "562183": 16, "623357": 17, "501202": 18, "522903": 19}, "history": [{"category": "Name", "history_type": "LSP", "note": "Name: SNQ2", "date_created": "2000-05-19", "references": [{"id": 599472, "display_name": "Servos J, et al. (1993)", "citation": "Servos J, et al. (1993) Gene SNQ2 of Saccharomyces cerevisiae, which confers resistance to 4-nitroquinoline-N-oxide and other chemicals, encodes a 169 kDa protein homologous to ATP-dependent permeases. Mol Gen Genet 236(2-3):214-8", "pubmed_id": 8437567, "link": "/reference/S000056063", "year": 1993, "urls": [{"display_name": "DOI full text", "link": "http://dx.doi.org/10.1007/BF00277115"}, {"display_name": "PubMed", "link": "http://www.ncbi.nlm.nih.gov/pubmed/8437567"}]}]}], "complexes": []}, tabs: {"id": 1266766, "protein_tab": true, "interaction_tab": true, "summary_tab": true, "go_tab": true, "sequence_section": true, "expression_tab": true, "phenotype_tab": true, "literature_tab": true, "wiki_tab": false, "regulation_tab": true, "sequence_tab": true, "history_tab": true, "homology_tab": true, "disease_tab": false} }; SNQ2 | SGD

AboutBlogDownloadExploreHelpGet Data

SNQ2 / YDR011W Overview

Standard Name
SNQ2 1
Systematic Name
YDR011W
SGD ID
SGD:S000002418
Feature Type
ORF , Verified
Description
Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species 2 3 4 5 6
Name Description
Sensitivity to 4-NitroQuinoline-N-oxide 1
Comparative Info
Sequence Details

Sequence

The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.

Analyze Sequence

S288C only

BLASTN | BLASTP | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation

S288C vs. other species

BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi

S288C vs. other strains

Strain Alignment | Variant Viewer

Protein Details

Protein

Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.

Length (a.a.)
1501
Mol. Weight (Da)
168770.1
Isoelectric Point
7.67
Median Abundance (molecules/cell)
4095 +/- 2614

Alleles

Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.

View all SNQ2 alleles in SGD search

Gene Ontology Details

Gene Ontology

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.

Summary
Plasma membrane ABC-type xenobiotic transporter; involved in cation homeostasis

View computational annotations

Molecular Function

Manually Curated

Biological Process

Manually Curated

Cellular Component

Manually Curated
Phenotype Details

Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.

Interaction Details

Interaction

Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.

165 total interactions for 147 unique genes

Physical Interactions

  • Affinity Capture-MS: 43
  • Affinity Capture-RNA: 9
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • Co-fractionation: 3
  • PCA: 33
  • Protein-RNA: 1

Genetic Interactions

  • Dosage Growth Defect: 1
  • Dosage Lethality: 2
  • Dosage Rescue: 2
  • Negative Genetic: 49
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 2
  • Positive Genetic: 6
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1
Regulation Details

Regulation

The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.

Regulators
17
Targets
0
Expression Details

Expression

Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.

Summary Paragraph

A summary of the locus, written by SGD Biocurators following a thorough review of the literature. Links to gene names and curated GO terms are included within the Summary Paragraphs.

Last Updated: 2011-01-13

Literature Details

Literature

All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.

Primary
76
Additional
142
Reviews
38

Resources

AlphaFold Protein Structure | Entrez Gene | Entrez RefSeq Protein | FungiDB | Search all NCBI | TCDB | UniParc | UniProtKB