Mark Kilgard's talk focuses on advancements in GPU-accelerated 2D graphics and web rendering, highlighting NVIDIA's approach to optimizing path rendering using a 'stencil, then cover' method for improved efficiency and quality. The presentation covers various applications, rendering standards, and the benefits of integrating resolution-independent graphics into web content. It aims to demonstrate how modern GPUs can significantly enhance rendering processes for both 3D and 2D content, making them essential for interactive visual computing.