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Volume 21 Issue 11, November 2025

Research to real world, inspired by the Editorial on p577

Cover design: Amie Fernandez

Editorial

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Q&A

  • To mark the 20th anniversary of Nature Reviews Neurology, we have asked leaders of neurological societies across the world to reflect on progress over the past two decades and consider what the future holds for neurology in their region. Here, we speak to Christopher Chen, President of the Asian and Oceanian Association of Neurology.

    • Ian Fyfe
    • Christopher Chen
    Q&A
  • To mark the 20th anniversary of Nature Reviews Neurology, we have asked leaders of neurological societies across the world to reflect on progress over the past two decades and consider what the future holds for neurology in their region. Here, we speak to Amina Gargouri and Riadh Gouider, President and Honorary President of the Pan-Arab Union of Neurological Societies.

    • Lisa Kiani
    • Amina Gargouri
    • Riadh Gouider
    Q&A
  • To mark the 20th anniversary of Nature Reviews Neurology, we have asked leaders of neurological societies across the world to reflect on progress over the past two decades and consider what the future holds for neurology in their region. Here, we speak to Lawrence Tucker and Augustina Charway-Felli, President and Past President, respectively, of the African Academy of Neurology.

    • Heather Wood
    • Lawrence Tucker
    • Augustina Charway-Felli
    Q&A
  • To mark the 20th anniversary of Nature Reviews Neurology, we have asked leaders of neurological societies across the world to reflect on progress over the past two decades and consider what the future holds for neurology in their region. Here, we speak to Elena Moro, President of the European Academy of Neurology.

    • Ian Fyfe
    • Elena Moro
    Q&A
  • To mark the 20th anniversary of Nature Reviews Neurology, we have asked leaders of neurological societies across the world to reflect on progress over the past two decades and consider what the future holds for neurology in their region. Here, we speak to Fernando Cendes, Vice President of the Pan American Federation of Neurology.

    • Lisa Kiani
    • Fernando Cendes
    Q&A
  • To mark the 20th anniversary of Nature Reviews Neurology, we have asked leaders of neurological societies across the world to reflect on progress over the past two decades and consider what the future holds for neurology in their region. Here, we speak to Natalia S. Rost, President of the American Academy of Neurology.

    • Heather Wood
    • Natalia S. Rost
    Q&A
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Research Highlights

  • A new study presented at the 2025 American Neurological Association Annual Meeting indicates that area postrema syndrome in people with neuromyelitis optica spectrum disorder is related to elevated levels of the gut hormone glucagon-like peptide 1 and its receptor GLP-1R.

    • Heather Wood
    Research Highlight
  • Glioblastomas can shift glucose metabolism from tricarboxylic acid cycle (TCA) oxidation and neurotransmitter synthesis to growth-promoting pathways, according to new research published in Nature.

    • Lisa Kiani
    Research Highlight
  • Cerebellar pathology in people with type 1 spinal muscular atrophy (SMA) might contribute to motor and social communication impairments associated with the disease, according to a recent study published in Brain.

    • Lisa Kiani
    Research Highlight
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Reviews

  • This Review considers the aetiology of health disparities in neurology at an individual, interpersonal, community and societal level, and suggests practical interventions to address the multifactorial issues.

    • Joshua A. Budhu
    • Nicte I. Mejia
    • Altaf Saadi
    Review Article
  • The neuronal ceroid lipofuscinoses, or Batten disease, are a group of fatal inherited neurodegenerative lysosomal storage disorders. Despite having defined genetic causes, the underlying disease mechanisms remain poorly understood and treatments are limited. Cooper and colleagues highlight recent advances in understanding the cell biology and disease pathogenesis, which could inform future therapeutic development.

    • Ewa A. Ziółkowska
    • Keigo Takahashi
    • Jonathan D. Cooper
    Review Article
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Perspectives

  • This Perspective centres on alterations in the fatty acid-ome as the critical feature of lipid aberration in α-synucleinopathies, specifically Parkinson disease. Here, the authors explain the biological and genetic basis for their hypothesis, with an emphasis on the transient binding of α-synuclein to fatty acids of various lipids.

    • Saranna Fanning
    • Dennis Selkoe
    Perspective
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