Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in disease. This Expert Recommendation article summarizes ferroptosis regulation and mechanisms and provides recommendations to increase the reproducibility and robustness of ferroptosis research.

Membrane contact sites between organelles facilitate the exchange of ions, lipids and metabolites. This Expert Recommendation highlights recent advances in defining the organelle contactome and discusses challenges and future directions in membrane contact site research.

In this Tools of the Trade article, Okuda and Kessler (Müller-McNicoll and Heilemann labs) discuss how the combination of two novel methods enabled them to study the architecture and interaction of nuclear membraneless organelles.

Two seminal studies from the 1980s catalysed major advances in the trafficking field, when converging research in yeast and mammalian cells revealed the molecular machinery of the secretory pathway.

The discovery of a cis-regulatory element required for xenobiotic gene activation highlighted the crucial role of enhancers in drug metabolism.

Latin American–Caribbean single-cell genomics initiatives are generating inclusive AI-ready data for precision medicine, and empowering the region’s scientists to become researcher leaders.

Christina Termini highlights the importance of the identification of haematopoietic stem cell markers.

The advent of laser-scanning confocal microscopy revolutionized cell biology, offering unprecedented resolution and depth and enabling scientists to visualize cellular structures in 3D.