Scientists can choose between multiple human genome references, and a pangenome reference is coming. Deciding what to use when is not quite straightforward.

Giotto Suite provides a comprehensive, flexible and scalable platform for technology-agnostic spatial omics analysis using R.

Tilt-corrected bright-field scanning transmission electron microscopy offers enhanced cryogenic electron microscopy contrast and substantial improvement in dose efficiency for thick samples such as bacterial cells and large organelles, while still being able to perform single-particle analysis.

PHLOWER leverages single-cell multimodal data to infer complex, multi-branching cell differentiation trajectories.

scooby achieves DNA sequence-based single-cell level modeling of RNA-sequencing coverage and ATAC-sequencing insertion profiles by adapting a deep learning model that predicts bulk RNA-sequencing coverage.

CELLECT learns contrastive embeddings to enable high-fidelity cell tracking.

gReLU advances deep-learning-based modeling and analysis of DNA sequences with comprehensive toolsets and versatile applications.

This Registered Report compares computational methods for single-cell multimodal omics integration and provides recommendations for different tasks and scenarios.

MrVI, based on deep generative modelling, is a unified framework for integrative, exploratory and comparative analyses of large-scale (multi-sample) single-cell RNA-seq datasets.

AI-designed binders can enhance prime editing performance by inhibiting the DNA mismatch repair pathway.

Team news, editorial projects and initiatives, plus a preview of what’s to come in 2026.