Early life is a critical window for immune development, marked by shifts in cell composition and function. Age and sex influence this process and are associated with epigenetic differences in immune-related DNA methylation, based on analysis of whole blood samples collected at ages 1 vs. 5 from a Canadian longitudinal paediatric cohort

The Human Cell Aging Transcriptome Atlas contains single cell RNA-sequencing data from 3,475 human samples and interactive tools to explore age-related alterations in gene expression and go term enrichment in a diverse set of tissues and cell types.

Deep learning-based interpolation using cryoTIGER enhances angular sampling in cryoET, improving 3D reconstructions, particle localization, and structural recovery without increasing electron dose.

Modelling cardiomyocyte geometry reveals that mitochondrial–sarcoplasmic architecture enhances respiration by facilitating ion and lipid transfer for efficient cardiac metabolism.

The quantitative proteome of Bdellovibrio bacteriovorus during its periplasmic predation on Escherichia coli detected a prey-lytic protease. This proteome is valuable to study this bacterial interaction and find novel antimicrobial enzymes.

Aged C. elegans fed Bacillus subtilis TO-A (BSTOA) maintain mobility and actin integrity and exhibit increased resistance to oxidative stress. These findings implicate BSTOA-induced maintenance of gpx-7 expression as a key mechanism.

FBXL5 deficiency in CD11c⁺ myeloid cells causes iron overload, enhancing NF-κB recruitment to the IL-6 promoter and increasing IL-6 production. This exacerbates neutrophil infiltration and liver injury in mice, while IL-6 neutralization mitigates damage, revealing iron regulation as a therapeutic target.

Localized intrathecal administration of KCC2-expressing AAV9s enhances functional recovery in cervical models of traumatic contusive-compression spinal cord injury by restoring balanced excitatory/inhibitory neurotransmission.

The mechanism by which SIRT5 mediates desuccinylation of MTHFD2 at lysine 44 reveals that SIRT5 influences therapy-induced senescence and chemoresistance in breast cancer cells through regulation of MTHFD2 desuccinylation.

The Bordetella spp. type 3 secretion system effector, BteA, targets epithelial cells and eosinophils to induce IL-1Ra secretion, providing a permissive environment and establishing long-term lung colonization.

Francesco Mattia Rossi is an Associate Professor in the Laboratorio de Neurociencias at the Facultad de Ciencias - Universidad de la República in Montevideo (Uruguay), investigating the mechanisms of neuronal plasticity in the visual cortex. In addition to his faculty role, Dr. Rossi chairs the Federation of Latin American and Caribbean Neuroscience Societies. In this Q&A, he discusses his career journey and his engagement in promoting (neuro)science research and education in Latin America and the Caribbean.

Ingrid Eftedal is a senior scientist at Norwegian University of Science and Technology Department of Circulation and Medical Imaging, Norway, and a leading expert in baromedicine. In this Q&A, we talk about what started her career and the challenges of conducting niche research.

In this interview, marine biologist Jasmin Graham shares about her experience building grassroots change in science, navigating exclusionary spaces and what it means to foster belonging in the ocean sciences.

Audrey Dussutour is a Research Director at the National Center for Scientific Research (Toulouse, France), specializing in the adaptive behaviors of ants and slime molds. She has authored over 70 scientific papers and four award-winning science books. Dr. Dussutour has led two influential citizen science projects: “Raise Your Blob”, engaging 350,000 students, and “Behind the Blob”, mobilizing 15,000 volunteers to study climate change impact on slime molds. Her science communication efforts have been recognized with the National Order of Merit and the first CNRS Medal for scientific outreach. In this Q&A, she discusses the fascinating world of social insects and slime molds, the challenges of pursuing basic research outside mainstream funding priorities, and the importance of science education.

As progress is made in sex-inclusive preclinical research, the author highlights areas of research practice where significant development has been achieved & where more change is needed towards community accepted standards in equitable research

Commentary recommending research directions for cellular agriculture that may lead to more socially desirable directions for the industry.