NFL Insider Tom Pelissero reports that San Francisco 49ers quarterback Brock Purdy and wide receiver Ricky Pearsall will be out for Sunday's matchup against the Houston Texans.

Quarterback Brock Purdy will miss his fourth straight game and sixth in the past seven weeks for the San Francisco 49ers with a toe injury. Coach Kyle Shanahan said Friday that Purdy was ruled out this week against the Houston Texans but will travel for the game as his condition has improved. Purdy skipped the past two road trips for San Francisco.

The 49ers' top quarterback has missed five of seven games this season so far. Here's the latest on his status for Week 8.

49ers quarterback Brock Purdy has been ruled out again this week.

The San Francisco 49ers will be without two key offensive starters once again as they take on an excellent Houston Texans defense in Week 8.

Deommodore Lenoir and Luke Gifford are officially questionable

San Francisco 49ers quarterback Brock Purdy continues progressing from his turf toe injury.

The "GMFB" hosts preview what to expect in the Week 8 matchup between the San Francisco 49ers and Houston Texans.

49ers starting quarterback Brock Purdy remained a limited participant in Thursday's practice.