Acta Pharmacologica Sinica

Structure genomics of SARS-CoV-2 and its Omicron variant

DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity

Yao Tu
Qing-yun Zhu
Yu-yang Jiang

Article 19 August 2025

Featured

Neuroglia and immune cells play different roles in neuroinflammation and neuroimmune response in post-stroke neural injury and repair

Hui Guo
Wen-cao Liu
Pan-pan Geng
Review Article12 Aug 2025
Novel anti-HER2 nanobody-drug conjugates with enhanced penetration of solid tumor and BBB, reduced systemic exposure and superior antitumor efficacy

Yue Wang
Liang Liu
Ker Yu
Article18 Aug 2025
Sirtuin 6 mitigates thoracic aortic aneurysm progression via maintenance of mitochondria homeostasis in vascular smooth muscle cells

Xiao-ting Yu
Nan Zhao
Ai-juan Qu
Article02 Sept 2025
NADPH acts as an endogenous P2X7 receptor modulator to gate neuroinflammatory responses of microglia

Yu-jie Mou
Feng-min Li
Zheng-hong Qin
Article11 Aug 2025

Current issue

Isoginkgetin, a natural biflavonoid from Ginkgo biloba, inhibits inflammatory response in endothelial cells via suppressing NF-ÎºB activation

Mei-jie Chen
Zhi-dan Zhang
Suo-wen Xu
Correspondence16 Jul 2025
Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseasesâ€”an update

Wei-long Wu
Xiao-xi Gong
Yan Wang
Review ArticleOpen Access19 May 2025
Peptide-MHC I regulatory mechanisms and intervention strategies in anti-tumor T cell immunity

Zhi-chao Zhang
Ying Shen
Wen-bin Zhao
Review Article16 May 2025
Metabolic enzyme-associated protein-protein interactions (mPPIs) in cancer: potential vulnerability for cancer treatment?

Yu-ting Tang
Tian-yi Chen
Ying Shen
Review Article20 Jun 2025
A rat Satb1 truncation causes neurodevelopmental abnormalities recapitulating the symptoms of patients with SATB1 mutations

Zhi-bin Hu
Wei-tang Liu
Yu-qiang Ding
ArticleOpen Access26 Jun 2025
G-protein coupled receptor kinase 2 mediates rheumatoid arthritis-induced depression-like behaviors via the hippocampal CRHR1 signaling pathway

Qian Meng
Meng-hui Guo
Wei Wei
Article21 Jul 2025

Volume 46 Issue 12

Contents

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Announcements

Editorial Excellence

Acta Pharmacologica Sinica, among the top 25% qualifying journals, is recognized for its exceptional editorial excellence, based on data collected from the 2024 Journal Author Satisfaction survey. Congratulations to the Acta Pharmacologica Sinica editors!

Browse articles

Modest improvement of metabolic and behavioral deficits with long-term ambroxol treatment in a Pink1^{âˆ’/âˆ’}SNCA^A53T double mutant mouse model of Parkinsonâ€™s disease

Luisa Franck
Lucie Valek
Irmgard Tegeder
ArticleOpen Access08 Dec 2025
GluD1 at the synaptic crossroads: from domain structure to circuit dysfunction

Poojashree B. Chettiar
Shashank M. Dravid
Review ArticleOpen Access04 Dec 2025
AI-driven breakthroughs in ion channel drug discovery: the future is now

Ming-yue Zheng
Zhao-bing Gao
Perspective02 Dec 2025
Adapter protein 2-modulated \({{{\rm{\mu }}}}\)-opioid receptor trafficking in paraventricular thalamus contributes to fentanyl contextual addiction memory in mice

Yu-jie Li
Ruo-song Chen
Zhi-qiang Liu
Article01 Dec 2025
Roles and related underlying mechanisms of mitochondrial RNA modification in cancer progression

Ling-zhi Wang
Tao-yu Yang
Jun-ming He
Review Article01 Dec 2025
ATM promotes bone metastatic propensity of breast cancer by inducing osteoclastogenesis via the NFÎºB-CCL2 pathway

Ming-yang Qin
Yuan-hui Liu
Rong Xu
Article01 Dec 2025
Serotonin receptor 4 in the ventral CA3 regulates agomelatine-induced anxiolytic-like behaviors

Xiang-hu Liu
Muhammad Naveed
Jing Zhang
Article01 Dec 2025
Graph-based deep learning approach for high-throughput protein-DNA interaction scoring

Yi-hao Zhao
Ying Wang
Yu Kang
Article01 Dec 2025
Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis

Yao Chen
Wen-qing Shi
Jian-ge Zhang
Article10 Nov 2025

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