Acta Pharmacologica Sinica APS (Acta Pharmacologica Sinica) publishes high quality content in all areas of pharmacology and the life sciences. Topics of particular interest include, but are not limited to, anticancer pharmacology, cardiovascular and pulmonary pharmacology, clinical pharmacology, drug discovery, gastrointestinal and hepatic pharmacology, genitourinary, renal and endocrine pharmacology, immunopharmacology and inflammation, molecular and cellular pharmacology, neuropharmacology, pharmaceutics and pharmacokinetics. http://feeds.nature.com/aps/rss/current Nature Publishing Group en © 2025 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Acta Pharmacologica Sinica © 2025 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. [email protected]
  • Acta Pharmacologica Sinica https://www.nature.com/uploads/product/aps/rss.png http://feeds.nature.com/aps/rss/current <![CDATA[Targeting the 5-HT<sub>1B</sub>-YAP positive feedback loop protects against disturbed flow-induced atherogenesis in mice]]> https://www.nature.com/articles/s41401-025-01672-x <![CDATA[
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    Acta Pharmacologica Sinica, Published online: 01 November 2025; doi:10.1038/s41401-025-01672-x

    Targeting the 5-HT1B-YAP positive feedback loop protects against disturbed flow-induced atherogenesis in mice]]> <![CDATA[Targeting the 5-HT<sub>1B</sub>-YAP positive feedback loop protects against disturbed flow-induced atherogenesis in mice]]> Min-chun JiangHuan-yu DingChak Kwong ChengDong-qin CaiHai-xia GuanJian KuangRonald Ching Wan MaYin XiaXiao-qiang YaoLi WangYu Huang doi:10.1038/s41401-025-01672-x Acta Pharmacologica Sinica, Published online: 2025-11-01; | doi:10.1038/s41401-025-01672-x 2025-11-01 Acta Pharmacologica Sinica 10.1038/s41401-025-01672-x https://www.nature.com/articles/s41401-025-01672-x <![CDATA[Galangin 3-methyl ether alleviates mouse hypertrophic cardiomyopathy via targeting HDAC2 and subsequently inactivating the PI3K-AKT signaling pathway]]> https://www.nature.com/articles/s41401-025-01676-7 <![CDATA[

    Acta Pharmacologica Sinica, Published online: 01 November 2025; doi:10.1038/s41401-025-01676-7

    Galangin 3-methyl ether alleviates mouse hypertrophic cardiomyopathy via targeting HDAC2 and subsequently inactivating the PI3K-AKT signaling pathway]]>     <![CDATA[Galangin 3-methyl ether alleviates mouse hypertrophic cardiomyopathy via targeting HDAC2 and subsequently inactivating the PI3K-AKT signaling pathway]]> Ke ZhangTao XuXin-yu HengJian-zhen LeiDe-shen HanShao-hong HuangMei-qi HeLin PuYue-yue WuNing SunHai YangChao Ye doi:10.1038/s41401-025-01676-7 Acta Pharmacologica Sinica, Published online: 2025-11-01; | doi:10.1038/s41401-025-01676-7 2025-11-01 Acta Pharmacologica Sinica 10.1038/s41401-025-01676-7 https://www.nature.com/articles/s41401-025-01676-7     <![CDATA[Lung memory B cells ameliorate Alzheimer’s disease-like pathology in 5×FAD mice through the CXCL12-CXCR4 axis]]> https://www.nature.com/articles/s41401-025-01667-8 <![CDATA[

    Acta Pharmacologica Sinica, Published online: 17 October 2025; doi:10.1038/s41401-025-01667-8

    Lung memory B cells ameliorate Alzheimer’s disease-like pathology in 5×FAD mice through the CXCL12-CXCR4 axis]]>     <![CDATA[Lung memory B cells ameliorate Alzheimer’s disease-like pathology in 5×FAD mice through the CXCL12-CXCR4 axis]]> Yan-li ZhangShi-xin DingMin CaoShu-ying ZhangYue LiZe WangYu-xi JinSi-jia ChenYi-miao WangCharles MarshallJing-ping ShiJun-ying GaoWei-xi FengYin CaoMing XiaoGang Hu doi:10.1038/s41401-025-01667-8 Acta Pharmacologica Sinica, Published online: 2025-10-17; | doi:10.1038/s41401-025-01667-8 2025-10-17 Acta Pharmacologica Sinica 10.1038/s41401-025-01667-8 https://www.nature.com/articles/s41401-025-01667-8     <![CDATA[Zinc pyrithione functions as a small-molecule STING agonist to exert antitumor immunotherapy effects]]> https://www.nature.com/articles/s41401-025-01674-9 <![CDATA[

    Acta Pharmacologica Sinica, Published online: 17 October 2025; doi:10.1038/s41401-025-01674-9

    Zinc pyrithione functions as a small-molecule STING agonist to exert antitumor immunotherapy effects]]>     <![CDATA[Zinc pyrithione functions as a small-molecule STING agonist to exert antitumor immunotherapy effects]]> Man ZhaoZu-yi JinWei-zhen FanPeng-fei QiangZhi-hua ZhengGuo-feng LiLiang HongMin Li doi:10.1038/s41401-025-01674-9 Acta Pharmacologica Sinica, Published online: 2025-10-17; | doi:10.1038/s41401-025-01674-9 2025-10-17 Acta Pharmacologica Sinica 10.1038/s41401-025-01674-9 https://www.nature.com/articles/s41401-025-01674-9     <![CDATA[An engineered IL-21 variant is a potent antitumor candidate for antitumor immunotherapy]]> https://www.nature.com/articles/s41401-025-01652-1 <![CDATA[

    Acta Pharmacologica Sinica, Published online: 17 October 2025; doi:10.1038/s41401-025-01652-1

    An engineered IL-21 variant is a potent antitumor candidate for antitumor immunotherapy]]>     <![CDATA[An engineered IL-21 variant is a potent antitumor candidate for antitumor immunotherapy]]> Hui WuYa-ping ChengYu-long LiuRuo-han ZhuLi-wen JiMing-kai WangQuan-xiao LiZhao-ling ShenTian-lei YingYan-ling Wu doi:10.1038/s41401-025-01652-1 Acta Pharmacologica Sinica, Published online: 2025-10-17; | doi:10.1038/s41401-025-01652-1 2025-10-17 Acta Pharmacologica Sinica 10.1038/s41401-025-01652-1 https://www.nature.com/articles/s41401-025-01652-1     <![CDATA[Inhibiting mPGES-2 impedes renal cyst growth in mice with polycystic kidney disease]]> https://www.nature.com/articles/s41401-025-01664-x <![CDATA[

    Acta Pharmacologica Sinica, Published online: 17 October 2025; doi:10.1038/s41401-025-01664-x

    Inhibiting mPGES-2 impedes renal cyst growth in mice with polycystic kidney disease]]>     <![CDATA[Inhibiting mPGES-2 impedes renal cyst growth in mice with polycystic kidney disease]]> Dan-dan ZhongCheng HuLan-lan ZhaoYan ShenRu-meng ZhangYing LiuBu-hui LiuWen SuBao-xue YangHui XiongDong GuoDong SunYing-ying ZouYing Sun doi:10.1038/s41401-025-01664-x Acta Pharmacologica Sinica, Published online: 2025-10-17; | doi:10.1038/s41401-025-01664-x 2025-10-17 Acta Pharmacologica Sinica 10.1038/s41401-025-01664-x https://www.nature.com/articles/s41401-025-01664-x     <![CDATA[Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis]]> https://www.nature.com/articles/s41401-025-01669-6 <![CDATA[

    Acta Pharmacologica Sinica, Published online: 13 October 2025; doi:10.1038/s41401-025-01669-6

    Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis]]>     <![CDATA[Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis]]> Jue WangWei-wei LiuQiong-lian HuangHan-juan NingJian-yi WangXiang-hui Han doi:10.1038/s41401-025-01669-6 Acta Pharmacologica Sinica, Published online: 2025-10-13; | doi:10.1038/s41401-025-01669-6 2025-10-13 Acta Pharmacologica Sinica 10.1038/s41401-025-01669-6 https://www.nature.com/articles/s41401-025-01669-6     <![CDATA[Retraction Note: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2]]> https://www.nature.com/articles/s41401-025-01685-6 <![CDATA[

    Acta Pharmacologica Sinica, Published online: 09 October 2025; doi:10.1038/s41401-025-01685-6

    Retraction Note: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2]]>     <![CDATA[Retraction Note: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2]]> Yan-tao HanXue-hong ChenHui GaoJun-li YeChun-bo Wang doi:10.1038/s41401-025-01685-6 Acta Pharmacologica Sinica, Published online: 2025-10-09; | doi:10.1038/s41401-025-01685-6 2025-10-09 Acta Pharmacologica Sinica 10.1038/s41401-025-01685-6 https://www.nature.com/articles/s41401-025-01685-6