Deconvolution of Blood Microarray Data Identifies Cellular Activation Patterns in Systemic Lupus Erythematosus
Figure 7
Significant relationships exist between activation patterns of different cell populations.
Visual analysis of T or NK cell types' abundance from individual donors of the main cohort reveals further patterns. (a) Plotting of resting vs. activated NK cells shows that activation of NK cells occurs to all NK cells simultaneously. (b) Plotting of resting vs. activated T helper cells shows that likewise activation of T cells occurs to all T cells simultaneously. (c) Plotting of activated NK cells vs. activated T helper cells shows that most patients' populations of these two cells appear to lie along a negatively sloped line. Linear least squares fitting to those samples yields a line of slope −1.00078. (d) Levels of resting and activated monocytes show a negative relationship with each other in both SLE and healthy donors.