Deconvolution of Blood Microarray Data Identifies Cellular Activation Patterns in Systemic Lupus Erythematosus
Figure 5
Complete leukocyte deconvolution of healthy or SLE whole blood shows significant differences.
(a) Deconvolved relative abundance of different leukocyte cell types and activation states exhibit statistically significant differences between healthy donors and SLE patients in many (noted by “*”; p-values are 8.6e-07, 3.1e-10, 3.5e-04, 1.5e-09, 1,1e-03, 1.6e-15, 2.2e-16, 6.9e-06, 1.1e-08, respectively). Quantile boxes and tails are 10%ile, 25%ile, 50%ile, 75%ile, and 90%ile. (b) Determination in healthy or SLE blood of relative abundance of total lymphocytes, monocytes, or neutrophils by CBC differential compared to determination of relative abundance by deconvolution. Diagonal lines are y = x, shown for reference, highlight the agreement between the two methods.