Deconvolution of Blood Microarray Data Identifies Cellular Activation Patterns in Systemic Lupus Erythematosus
Figure 1
Expression deconvolution was characterized using mixtures of cell lines.
(a) Two-dimensional hierarchical clustering of pure cell line samples and the probesets used as bases in deconvolution show strong segregation of cell lines and clear patterns to support deconvolution. (b) Plotting of proportions of cell lines determined from deconvolution vs. proportions of the cell lines actually mixed shows strong congruence (RMS error = 0.028).