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Modulation of Macrophage Activation State Protects Tissue from Necrosis during Critical Limb Ischemia in Thrombospondin-1-Deficient Mice

Figure 2

Clinical necrosis is reduced in tsp-1−/− mice.

(A) Pictures show mice either protected from necrosis (left) or affected by necrosis (right). (B) Cumulative incidence of necrosis was followed during 21 days after ischemia in both wt and tsp-1−/− mice and represented as Kaplan-Meier estimates (n = 19; p<0.05 tsp-1−/− vs. wt).

Figure 2

doi: https://doi.org/10.1371/journal.pone.0003950.g002