Elongator Complex Influences Telomeric Gene Silencing and DNA Damage Response by Its Role in Wobble Uridine tRNA Modification
Figure 7
The tuc2Δ strain is deficient in telomeric gene silencing and show increased HU sensitivity.
(A) The wild type strain (UMY2584) harboring plasmid pRS425 and the tuc2Δ mutant (UMY3804) harboring plasmids pRS425-tK-tQ-tE or pRS425 were assayed as described in Figure 1. (B) The wild type strain (UMY2067) harboring plasmid pRS425 and the tuc2Δ mutant (UMY3442) harboring plasmids pRS425-tK-tQ-tE or pRS425 were assayed as described in Figure 2. Abbreviations for the tRNA genes encoding ,
and
are tK, tQ and tE, respectively.