A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress
Figure 3
Principal component analysis (PCA) of changes in the levels of tRNA modifications caused by exposure to MMS, H2O2, NaOCl, and NaAsO2.
Toxicant-induced changes in the relative quantities of 23 tRNA ribonucleoside modifications (Table S2) were subjected to PCA following mean centering and normalization of the fold-change data.