Abstract
As key regulators of the cell cycle, the cyclin-dependent kinases must be tightly regulated by extra- and intracellular signals. The activity of cyclin-dependent kinases is controlled by four highly conserved biochemical mechanisms, forming a web of regulatory pathways unmatched in its elegance and intricacy.
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References
Norbury, C. & Nurse, P. A. Rev. Biochem. 61, 441–470 (1992).
Nasmyth, K. Curr. Opin. Cell Biol. 5, 166–179 (1993).
Reed, S. I. Rev. Cell Biol. 8, 529–561 (1992).
Sherr, C. J. Cell 73, 1059–1065 (1993).
Kaffman, A., Herskowitz, I., Tjian, R. & O'Shea, E. K. Science 263, 1153–1156 (1994).
Schneider, K. R., Smith, R. L. & O'Shea, E. K. Science 266, 122–126 (1994).
Lew, J. et al. Nature 371, 423–426 (1994).
Tsai, L.-H., Delalle, I., Caviness, V. S., Chae, T. & Harlow, E. Nature 371, 419–423 (1994).
Espinoza, F. H., Ogas, J., Herskowitz, I. & Morgan, D. O. Science 266, 1388–1391 (1994).
Measday, V., Moore, L., Ogas, J., Tyers, M. & Andrews, B. Science 266, 1391–1395 (1994).
Valay, J. G., Simon, M. & Faye, G. J. molec. Biol. 234, 307–310 (1993).
De Bondt, H. L. et al. Nature 363, 595–602 (1993).
Morgan, D. O. & De Bondt, H. L. Curr. Opin. Cell Biol. 6, 239–246 (1994).
Kobayashi, H. et al. Molec. Biol. Cell 3, 1279–1294 (1992).
Lees, E. M. & Harlow, E. Molec. cell. Biol. 13, 1194–1201 (1993).
Glotzer, M., Murray, A. W. & Kirschner, M. W. Nature 349, 132–138 (1991).
Hershko, A. et al. J. biol. Chem. 269, 4940–4946 (1994).
Pines, J. & Hunter, T. Cell 58, 833–846 (1989).
Pines, J. & Hunter, T. Nature 346, 760–763 (1990).
Lew, D. J., Dulic, V. & Reed, S. I. Cell 66, 1197–1206 (1991).
Amon, A., Irniger, S. & Nasmyth, K. Cell 77, 1037–1050 (1994).
Amon, A., Tyers, M., Futcher, B. & Nasmyth, K. Cell 74, 993–1007 (1993).
Hoffman, I., Clarke, P. R., Marcote, M. J., Karsenti, E. & Draetta, G. EMBO J 12, 53–63 (1993).
Peeper, D. S. et al. EMBO J. 12, 1947–1954 (1993).
Dynlacht, B. D., Flores, O., Lees, J. A. & Harlow, E. Genes Dev. 8, 1772–1786 (1994).
Ducommun, B. et al. EMBO J. 10, 3311–3319 (1991).
Desai, D., Wessling, H. C., Fisher, R. P. & Morgan, D. O. Molec. cell. Biol. 15, 345–350 (1995).
Fesquet, D. et al. EMBO J. 12, 3111–3121 (1993).
Poon, R. Y. C., Yamashita, K., Adamczewski, J. P., Hunt, T. & Shuttleworth, J. EMBO J. 12, 3123–3132 (1993).
Solomon, M, J., Harper, J. W. & Shuttleworth, J. EMBO J. 12, 3133–3142 (1993).
Tassan, J.-P., Schultz, S. J., Bartek, J. & Nigg, E. A. J. Cell biol. 127, 467–478 (1994).
Poon, R. Y. C. et al. J. Cell Sci. 107, 2789–2799 (1994).
Fisher, R. P. & Morgan, D. O. Cell 78, 713–724 (1994).
Matsuoka, M., Kato, J., Fisher, R. P., Morgan, D. O. & Sherr, C. J. Molec. cell. Biol. 14, 7265–7275 (1994).
Makela, T. P. et al. Nature 371, 254–257 (1994).
Krek, W. & Nigg, E. A. EMBO J. 10, 305–316 (1991).
Gu, Y., Rosenblatt, J. & Morgan, D. O. EMBO J. 11, 3995–4005 (1992).
Brown, A. J., Jones, T. & Shuttleworth, J. Molec. Biol. Cell 5, 921–932 (1994).
Atherton-Fessler, S., Parker, L. L., Geahlen, R. L. & Piwnica-Worms, H. Molec. cell. Biol. 13, 1675–1685 (1993).
Solomon, M., Glotzer, M., Lee, T. H., Phillipe, M. & Kirschner, M. Cell 63, 1013–1024 (1990).
Parker, L. L. & Piwnica-Worms, H. Science 257, 1955–1957 (1992).
McGowan, C. H. & Russell, P. EMBO J. 12, 75–85 (1993).
Kornbluth, S., Sebastian, B., Hunter, T. & Newport, J. Molec. Biol. Cell 5, 273–282 (1994).
Atherton-Fessler, S. et al. Molec. Biol. Cell 5, 989–1001 (1994).
Coleman, T. R., Tang, Z. & Dunphy, W. G. Cell 72, 919–929 (1993).
Parker, L. L., Walter, S. A., Young, P. G. & Piwnica-Worms, H. Nature 363, 736–738 (1993).
Wu, L. & Russell, P. Nature 363, 738–741 (1993).
Tang, Z., Coleman, T. R. & Dunphy, W. G. EMBO J. 12, 3427–3436 (1993).
Dunphy, W. G. Trends Cell Biol. 4, 202–207 (1994).
Izumi, T. & Maller, J. L. Molec. Biol. Cell 4, 1337–1350 (1993).
Chang, F. & Herskowitz, I. Cell 63, 999–1011 (1990).
Peter, M., Gartner, A., Horecka, J., Ammerer, G. & Herskowitz, I. Cell 73, 747–60 (1993).
Peter, M. & Herskowitz, I. Science 265, 1228–1231 (1994).
Mendenhall, M. D. Science 259, 216–219 (1993).
Nugroho, T. T. & Mendenhall, M. D. Molec. cell. Biol. 14, 3320–3328 (1994).
Donovan, J. D., Toyn, J. H., Johnson, A. L. & Johnston, L. H. Genes Dev. 8, 1640–1653 (1994).
Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K. & Elledge, S. J. Cell 75, 805–816 (1993).
El-Deiry, W. S. et al. Cell 75, 817–825 (1993).
Xiong, Y. et al. Nature 366, 701–704 (1993).
Gu, Y., Turck, C. W. & Morgan, D. O. Nature 366, 707–710 (1993).
Noda, A., Ning, Y., Venable, S. F., Pereira-Smith, O. M. & Smith, J. R. Expl Cell Res. 211, 90–98 (1994).
Polyak, K. et al. Genes Dev. 8, 9–22 (1994).
Polyak, K. et al. Cell 78, 59–66 (1994).
Toyoshima, H. & Hunter, T. Cell 78, 67–74 (1994).
Serrano, M., Hannon, G. J. & Beach, D. Nature 366, 704–707 (1993).
Hannon, G. J. & Beach, D. Nature 371, 257–261 (1994).
Zhang, H., Hannon, G. J. & Beach, D. Genes Dev. 8, 1750–1758 (1994).
El-Deiry, W. S. et al. Cancer Res. 54, 1169–1174 (1994).
Dulic, V. et al. Cell 76, 1013–1023 (1994).
Kato, J., Matsuoka, M., Polyak, K., Massague, J. & Sherr, C. J. Cell 79, 487–496 (1994).
Firpo, E. J., Koff, A., Solomon, M. J. & Roberts, J. M. Molec. cell. Biol. 14, 4889–4901 (1994).
McKinney, J. D., Chang, F., Heintz, N. & Cross, F. R. Genes Dev. 7, 833–843 (1993).
Schwob, E., Bohm, T., Mendenhall, M. D. & Nasmyth, K. Cell 79, 233–244 (1994).
Parge, H. E., Arvai, A. S., Murtari, D. J., Reed, S. I. & Tainer, J. A. Science 262, 387–395 (1993).
Wang, T. C. et al. Nature 369, 669–671 (1994).
Bonetta, L. Nature 370, 180 (1994).
Wainwright, B. Nature Genet. 8, 3–5 (1994).
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Morgan, D. Principles of CDK regulation. Nature 374, 131–134 (1995). https://doi.org/10.1038/374131a0
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DOI: https://doi.org/10.1038/374131a0
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