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AP-1 in mouse development and tumorigenesis

Oncogene volume 20, pages 2401–2412 (2001)Cite this article

Abstract

Genetically modified mice have provided important insights into the biological functions of the dimeric transcription factor complex AP-1. Extensive analyses of mice and cells with genetically modified Fos or Jun proteins provide novel insights into the physiological functions of AP-1 proteins. Using knock-out strategies it was found that some components, such as c-Fos, FosB and JunD are dispensable, whereas others, like c-Jun, JunB and Fra-1 are essential in embryonic development and/or in the adult organism. Besides the specific roles of AP-1 proteins in developmental processes, we are beginning to obtain a better molecular understanding of the cell-context dependent function of AP-1 in cell proliferation and apoptosis, in bone biology as well as in multistep tumorigenesis.

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Acknowledgements

The authors thank A Fleischmann, A Grigoriadis, K Matsuo, M Sibilia and M Schorpp-Kistner for critical comments on the manuscript. The authors acknowledge the financial support from the EC TMR network.

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  1. Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, Vienna, A-1030, Austria

    Wolfram Jochum, Emmanuelle Passegué & Erwin F Wagner

  2. Institute of Clinical Pathology, University Hospital, Schmelzbergstrasse 12, Zurich, CH-8091, Switzerland

    Wolfram Jochum

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Jochum, W., Passegué, E. & Wagner, E. AP-1 in mouse development and tumorigenesis. Oncogene 20, 2401–2412 (2001). https://doi.org/10.1038/sj.onc.1204389

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