Oncogene Oncogene aims to make substantial advances in our knowledge of processes that contribute to cancer by publishing outstanding research. Oncogene propagates work that challenges standard conjecture and builds on previous studies, in particular those that lead to establishing new paradigms in the etio-pathogenesis, diagnosis, treatment, or prevention of cancers, and in processes that drive metastatic spread, and provide important insights into cancer biology beyond what has been revealed thus far. Areas covered by Oncogene include, but are not limited to, the cellular and molecular biology of cancer including resistance to cancer therapies, and development of better approaches to improving survival. Across cancer biology, we have a broad remit encompassing the life sciences and biomedicine, from the most fundamental and theoretical work, through to translational, applied, and clinical research. http://feeds.nature.com/onc/rss/current Nature Publishing Group en © 2025 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Oncogene © 2025 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. [email protected]
  • Oncogene https://www.nature.com/uploads/product/onc/rss.gif http://feeds.nature.com/onc/rss/current <![CDATA[USP10 promotes cell proliferation and gemcitabine resistance in pancreatic cancer by the regulation of IGF2BP3-STEAP3]]> https://www.nature.com/articles/s41388-025-03654-z <![CDATA[
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    Oncogene, Published online: 11 December 2025; doi:10.1038/s41388-025-03654-z

    USP10 promotes cell proliferation and gemcitabine resistance in pancreatic cancer by the regulation of IGF2BP3-STEAP3]]> <![CDATA[USP10 promotes cell proliferation and gemcitabine resistance in pancreatic cancer by the regulation of IGF2BP3-STEAP3]]> Yong-Ling LiangCheng-Rui ZhongJia-Yan WuZe-Jin LinZhu LinTai-Jun YiZhi-Ping ChenHui-Lin JinJian-Dong YuZe-Yu LinYun-Le WanGuo-Lin Li doi:10.1038/s41388-025-03654-z Oncogene, Published online: 2025-12-11; | doi:10.1038/s41388-025-03654-z 2025-12-11 Oncogene 10.1038/s41388-025-03654-z https://www.nature.com/articles/s41388-025-03654-z <![CDATA[Role of a transmembrane protein, epithelial membrane protein 1, in the pathogenesis of pancreatic ductal adenocarcinoma]]> https://www.nature.com/articles/s41388-025-03633-4 <![CDATA[

    Oncogene, Published online: 10 December 2025; doi:10.1038/s41388-025-03633-4

    Role of a transmembrane protein, epithelial membrane protein 1, in the pathogenesis of pancreatic ductal adenocarcinoma]]>     <![CDATA[Role of a transmembrane protein, epithelial membrane protein 1, in the pathogenesis of pancreatic ductal adenocarcinoma]]> Akihisa OhnoNao FujimoriKazuhide MatsumotoShojiro HajiOsamu SugaharaAyumu TakenoTakeo YamamotoAkihiko SuenagaShotaro KakehashiTakahiro UedaMasatoshi MurakamiKatsuhito TeramatsuKeijiro UedaTakamasa OonoYoshinao OdaKeiichi I. NakayamaYoshihiro Ogawa doi:10.1038/s41388-025-03633-4 Oncogene, Published online: 2025-12-10; | doi:10.1038/s41388-025-03633-4 2025-12-10 Oncogene 10.1038/s41388-025-03633-4 https://www.nature.com/articles/s41388-025-03633-4     <![CDATA[circSETD3 confers radiotherapy resistance in nasopharyngeal carcinoma by attenuating ER stress-induced autophagy and apoptosis via PDIA6 upregulation]]> https://www.nature.com/articles/s41388-025-03652-1 <![CDATA[

    Oncogene, Published online: 08 December 2025; doi:10.1038/s41388-025-03652-1

    circSETD3 confers radiotherapy resistance in nasopharyngeal carcinoma by attenuating ER stress-induced autophagy and apoptosis via PDIA6 upregulation]]>     <![CDATA[circSETD3 confers radiotherapy resistance in nasopharyngeal carcinoma by attenuating ER stress-induced autophagy and apoptosis via PDIA6 upregulation]]> Pingjuan XiangLe TangYi ZhangJuana Jessica MendozaQijia YanLei ShiBo XiangZhaoyang ZengPan ChenDan WangWei Xiong doi:10.1038/s41388-025-03652-1 Oncogene, Published online: 2025-12-08; | doi:10.1038/s41388-025-03652-1 2025-12-08 Oncogene 10.1038/s41388-025-03652-1 https://www.nature.com/articles/s41388-025-03652-1     <![CDATA[Molecular stratification of esophageal adenocarcinoma: implications for prognosis and treatment strategy]]> https://www.nature.com/articles/s41388-025-03650-3 <![CDATA[

    Oncogene, Published online: 08 December 2025; doi:10.1038/s41388-025-03650-3

    Molecular stratification of esophageal adenocarcinoma: implications for prognosis and treatment strategy]]>     <![CDATA[Molecular stratification of esophageal adenocarcinoma: implications for prognosis and treatment strategy]]> Rita PintoIngrid Vikan SjurgardHeidi PharoTom MalaHege Marie VedeldGuro Elisabeth Lind doi:10.1038/s41388-025-03650-3 Oncogene, Published online: 2025-12-08; | doi:10.1038/s41388-025-03650-3 2025-12-08 Oncogene 10.1038/s41388-025-03650-3 https://www.nature.com/articles/s41388-025-03650-3     <![CDATA[RBM8A confers oxaliplatin resistance in gastric cancer by maintaining EGFR mRNA stability]]> https://www.nature.com/articles/s41388-025-03655-y <![CDATA[

    Oncogene, Published online: 07 December 2025; doi:10.1038/s41388-025-03655-y

    RBM8A confers oxaliplatin resistance in gastric cancer by maintaining EGFR mRNA stability]]>     <![CDATA[RBM8A confers oxaliplatin resistance in gastric cancer by maintaining EGFR mRNA stability]]> Yichun MaYing XiangMei YangYanmei ZhuYani PanNannan ZhangXueni FuPing JiangYinya PanHai WuQiong YanWenjun LiHongji TaoShangtao MaoYufei TaoJiale LiLinzhe SuGuangtao GaoFangmei AnZhangding WangGuifang Xu doi:10.1038/s41388-025-03655-y Oncogene, Published online: 2025-12-07; | doi:10.1038/s41388-025-03655-y 2025-12-07 Oncogene 10.1038/s41388-025-03655-y https://www.nature.com/articles/s41388-025-03655-y     <![CDATA[Correction: Activated MAFB in ovarian cancer promotes cytoskeletal remodeling and immune microenvironment suppression by interfering with m6A modifications through WTAP competition]]> https://www.nature.com/articles/s41388-025-03656-x <![CDATA[

    Oncogene, Published online: 05 December 2025; doi:10.1038/s41388-025-03656-x

    Correction: Activated MAFB in ovarian cancer promotes cytoskeletal remodeling and immune microenvironment suppression by interfering with m6A modifications through WTAP competition]]>     <![CDATA[Correction: Activated MAFB in ovarian cancer promotes cytoskeletal remodeling and immune microenvironment suppression by interfering with m6A modifications through WTAP competition]]> Qinke LiSiying ZhangMin WangQiang YiHang XuJinlong WangZhu Yang doi:10.1038/s41388-025-03656-x Oncogene, Published online: 2025-12-05; | doi:10.1038/s41388-025-03656-x 2025-12-05 Oncogene 10.1038/s41388-025-03656-x https://www.nature.com/articles/s41388-025-03656-x     <![CDATA[Unveiling EMC6 as a novel pathogenic determinant in hepatocellular carcinoma: orchestration of lipid metabolism through regulation of lipid droplet-associated enzyme HSD17B13]]> https://www.nature.com/articles/s41388-025-03649-w <![CDATA[

    Oncogene, Published online: 03 December 2025; doi:10.1038/s41388-025-03649-w

    Unveiling EMC6 as a novel pathogenic determinant in hepatocellular carcinoma: orchestration of lipid metabolism through regulation of lipid droplet-associated enzyme HSD17B13]]>     <![CDATA[Unveiling EMC6 as a novel pathogenic determinant in hepatocellular carcinoma: orchestration of lipid metabolism through regulation of lipid droplet-associated enzyme HSD17B13]]> Yun ZhangChanyu XiongZhilin JiangXiao WangZihao WangJunyao ChenQiong LiYangyang LuoXudan YangChen ChuShikai ZhuXianjun ZhuYu Zhou doi:10.1038/s41388-025-03649-w Oncogene, Published online: 2025-12-03; | doi:10.1038/s41388-025-03649-w 2025-12-03 Oncogene 10.1038/s41388-025-03649-w https://www.nature.com/articles/s41388-025-03649-w     <![CDATA[Targeted methylation of cg24067911 suppresses colorectal cancer metastasis through BCL6-ATXN1-CDH1 axis]]> https://www.nature.com/articles/s41388-025-03638-z <![CDATA[

    Oncogene, Published online: 02 December 2025; doi:10.1038/s41388-025-03638-z

    Targeted methylation of cg24067911 suppresses colorectal cancer metastasis through BCL6-ATXN1-CDH1 axis]]>     <![CDATA[Targeted methylation of cg24067911 suppresses colorectal cancer metastasis through BCL6-ATXN1-CDH1 axis]]> Lu-Ping YangJia-Qian HuangChiu-Wing YeungQi-Hua ZhangXiao-Li WeiQi-Nian WuZi-Xin QinYa-Shang ZhengYu-Hong XuMeng YangKai-Ying ZhangZhi-Jun ZuoZhen-Yong QuanLang ZhaoDong-Yang HeJia LiuRui-Hua XuHui-Yan Luo doi:10.1038/s41388-025-03638-z Oncogene, Published online: 2025-12-02; | doi:10.1038/s41388-025-03638-z 2025-12-02 Oncogene 10.1038/s41388-025-03638-z https://www.nature.com/articles/s41388-025-03638-z