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| Official Gene Symbol | Other Aliases |
|---|---|
| MTOR | FRAP, FRAP1, FRAP2, RAFT1, RAPT1 |
| Sequence Length (AA) | Molecular Weight (Da) |
|---|---|
| 2549 | 288892 |
| Protein Name |
|---|
| Serine/threonine-protein kinase mTOR |
| Sources | |
|---|---|
|
UniProt PhosphoSitePlus ® GeneCards |
Human Protein Atlas |
| 10 | 20 | 30 | 40 | 50 |
| MLGTGPAAAT | TAATTSSNVS | VLQQFASGLK | SRNEETRAKA | AKELQHYVTM |
| 60 | 70 | 80 | 90 | 100 |
| ELREMSQEES | TRFYDQLNHH | IFELVSSSDA | NERKGGILAI | ASLIGVEGGN |
| 110 | 120 | 130 | 140 | 150 |
| ATRIGRFANY | LRNLLPSNDP | VVMEMASKAI | GRLAMAGDTF | TAEYVEFEVK |
| 160 | 170 | 180 | 190 | 200 |
| RALEWLGADR | NEGRRHAAVL | VLRELAISVP | TFFFQQVQPF | FDNIFVAVWD |
| 210 | 220 | 230 | 240 | 250 |
| PKQAIREGAV | AALRACLILT | TQREPKEMQK | PQWYRHTFEE | AEKGFDETLA |
| 260 | 270 | 280 | 290 | 300 |
| KEKGMNRDDR | IHGALLILNE | LVRISSMEGE | RLREEMEEIT | QQQLVHDKYC |
| 310 | 320 | 330 | 340 | 350 |
| KDLMGFGTKP | RHITPFTSFQ | AVQPQQSNAL | VGLLGYSSHQ | GLMGFGTSPS |
| 360 | 370 | 380 | 390 | 400 |
| PAKSTLVESR | CCRDLMEEKF | DQVCQWVLKC | RNSKNSLIQM | TILNLLPRLA |
| 410 | 420 | 430 | 440 | 450 |
| AFRPSAFTDT | QYLQDTMNHV | LSCVKKEKER | TAAFQALGLL | SVAVRSEFKV |
| 460 | 470 | 480 | 490 | 500 |
| YLPRVLDIIR | AALPPKDFAH | KRQKAMQVDA | TVFTCISMLA | RAMGPGIQQD |
| 510 | 520 | 530 | 540 | 550 |
| IKELLEPMLA | VGLSPALTAV | LYDLSRQIPQ | LKKDIQDGLL | KMLSLVLMHK |
| 560 | 570 | 580 | 590 | 600 |
| PLRHPGMPKG | LAHQLASPGL | TTLPEASDVG | SITLALRTLG | SFEFEGHSLT |
| 610 | 620 | 630 | 640 | 650 |
| QFVRHCADHF | LNSEHKEIRM | EAARTCSRLL | TPSIHLISGH | AHVVSQTAVQ |
| 660 | 670 | 680 | 690 | 700 |
| VVADVLSKLL | VVGITDPDPD | IRYCVLASLD | ERFDAHLAQA | ENLQALFVAL |
| 710 | 720 | 730 | 740 | 750 |
| NDQVFEIREL | AICTVGRLSS | MNPAFVMPFL | RKMLIQILTE | LEHSGIGRIK |
| 760 | 770 | 780 | 790 | 800 |
| EQSARMLGHL | VSNAPRLIRP | YMEPILKALI | LKLKDPDPDP | NPGVINNVLA |
| 810 | 820 | 830 | 840 | 850 |
| TIGELAQVSG | LEMRKWVDEL | FIIIMDMLQD | SSLLAKRQVA | LWTLGQLVAS |
| 860 | 870 | 880 | 890 | 900 |
| TGYVVEPYRK | YPTLLEVLLN | FLKTEQNQGT | RREAIRVLGL | LGALDPYKHK |
| 910 | 920 | 930 | 940 | 950 |
| VNIGMIDQSR | DASAVSLSES | KSSQDSSDYS | TSEMLVNMGN | LPLDEFYPAV |
| 960 | 970 | 980 | 990 | 1000 |
| SMVALMRIFR | DQSLSHHHTM | VVQAITFIFK | SLGLKCVQFL | PQVMPTFLNV |
| 1010 | 1020 | 1030 | 1040 | 1050 |
| IRVCDGAIRE | FLFQQLGMLV | SFVKSHIRPY | MDEIVTLMRE | FWVMNTSIQS |
| 1060 | 1070 | 1080 | 1090 | 1100 |
| TIILLIEQIV | VALGGEFKLY | LPQLIPHMLR | VFMHDNSPGR | IVSIKLLAAI |
| 1110 | 1120 | 1130 | 1140 | 1150 |
| QLFGANLDDY | LHLLLPPIVK | LFDAPEAPLP | SRKAALETVD | RLTESLDFTD |
| 1160 | 1170 | 1180 | 1190 | 1200 |
| YASRIIHPIV | RTLDQSPELR | STAMDTLSSL | VFQLGKKYQI | FIPMVNKVLV |
| 1210 | 1220 | 1230 | 1240 | 1250 |
| RHRINHQRYD | VLICRIVKGY | TLADEEEDPL | IYQHRMLRSG | QGDALASGPV |
| 1260 | 1270 | 1280 | 1290 | 1300 |
| ETGPMKKLHV | STINLQKAWG | AARRVSKDDW | LEWLRRLSLE | LLKDSSSPSL |
| 1310 | 1320 | 1330 | 1340 | 1350 |
| RSCWALAQAY | NPMARDLFNA | AFVSCWSELN | EDQQDELIRS | IELALTSQDI |
| 1360 | 1370 | 1380 | 1390 | 1400 |
| AEVTQTLLNL | AEFMEHSDKG | PLPLRDDNGI | VLLGERAAKC | RAYAKALHYK |
| 1410 | 1420 | 1430 | 1440 | 1450 |
| ELEFQKGPTP | AILESLISIN | NKLQQPEAAA | GVLEYAMKHF | GELEIQATWY |
| 1460 | 1470 | 1480 | 1490 | 1500 |
| EKLHEWEDAL | VAYDKKMDTN | KDDPELMLGR | MRCLEALGEW | GQLHQQCCEK |
| 1510 | 1520 | 1530 | 1540 | 1550 |
| WTLVNDETQA | KMARMAAAAA | WGLGQWDSME | EYTCMIPRDT | HDGAFYRAVL |
| 1560 | 1570 | 1580 | 1590 | 1600 |
| ALHQDLFSLA | QQCIDKARDL | LDAELTAMAG | ESYSRAYGAM | VSCHMLSELE |
| 1610 | 1620 | 1630 | 1640 | 1650 |
| EVIQYKLVPE | RREIIRQIWW | ERLQGCQRIV | EDWQKILMVR | SLVVSPHEDM |
| 1660 | 1670 | 1680 | 1690 | 1700 |
| RTWLKYASLC | GKSGRLALAH | KTLVLLLGVD | PSRQLDHPLP | TVHPQVTYAY |
| 1710 | 1720 | 1730 | 1740 | 1750 |
| MKNMWKSARK | IDAFQHMQHF | VQTMQQQAQH | AIATEDQQHK | QELHKLMARC |
| 1760 | 1770 | 1780 | 1790 | 1800 |
| FLKLGEWQLN | LQGINESTIP | KVLQYYSAAT | EHDRSWYKAW | HAWAVMNFEA |
| 1810 | 1820 | 1830 | 1840 | 1850 |
| VLHYKHQNQA | RDEKKKLRHA | SGANITNATT | AATTAATATT | TASTEGSNSE |
| 1860 | 1870 | 1880 | 1890 | 1900 |
| SEAESTENSP | TPSPLQKKVT | EDLSKTLLMY | TVPAVQGFFR | SISLSRGNNL |
| 1910 | 1920 | 1930 | 1940 | 1950 |
| QDTLRVLTLW | FDYGHWPDVN | EALVEGVKAI | QIDTWLQVIP | QLIARIDTPR |
| 1960 | 1970 | 1980 | 1990 | 2000 |
| PLVGRLIHQL | LTDIGRYHPQ | ALIYPLTVAS | KSTTTARHNA | ANKILKNMCE |
| 2010 | 2020 | 2030 | 2040 | 2050 |
| HSNTLVQQAM | MVSEELIRVA | ILWHEMWHEG | LEEASRLYFG | ERNVKGMFEV |
| 2060 | 2070 | 2080 | 2090 | 2100 |
| LEPLHAMMER | GPQTLKETSF | NQAYGRDLME | AQEWCRKYMK | SGNVKDLTQA |
| 2110 | 2120 | 2130 | 2140 | 2150 |
| WDLYYHVFRR | ISKQLPQLTS | LELQYVSPKL | LMCRDLELAV | PGTYDPNQPI |
| 2160 | 2170 | 2180 | 2190 | 2200 |
| IRIQSIAPSL | QVITSKQRPR | KLTLMGSNGH | EFVFLLKGHE | DLRQDERVMQ |
| 2210 | 2220 | 2230 | 2240 | 2250 |
| LFGLVNTLLA | NDPTSLRKNL | SIQRYAVIPL | STNSGLIGWV | PHCDTLHALI |
| 2260 | 2270 | 2280 | 2290 | 2300 |
| RDYREKKKIL | LNIEHRIMLR | MAPDYDHLTL | MQKVEVFEHA | VNNTAGDDLA |
| 2310 | 2320 | 2330 | 2340 | 2350 |
| KLLWLKSPSS | EVWFDRRTNY | TRSLAVMSMV | GYILGLGDRH | PSNLMLDRLS |
| 2360 | 2370 | 2380 | 2390 | 2400 |
| GKILHIDFGD | CFEVAMTREK | FPEKIPFRLT | RMLTNAMEVT | GLDGNYRITC |
| 2410 | 2420 | 2430 | 2440 | 2450 |
| HTVMEVLREH | KDSVMAVLEA | FVYDPLLNWR | LMDTNTKGNK | RSRTRTDSYS |
| 2460 | 2470 | 2480 | 2490 | 2500 |
| AGQSVEILDG | VELGEPAHKK | TGTTVPESIH | SFIGDGLVKP | EALNKKAIQI |
| 2510 | 2520 | 2530 | 2540 | 2549 |
| INRVRDKLTG | RDFSHDDTLD | VPTQVELLIK | QATSHENLCQ | CYIGWCPFW |
Data source: UniProt
Uniprot Database Entry PhosphoSitePlus ®
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Data source: Panorama
View Details (opens in a new window)
Mol Cell Proteomics. 2016 May;15(5):1622-41. doi: 10.1074/mcp.M116.058354. Epub 2016 Feb 24. Reduced-representation Phosphosignatures Measured by Quantitative Targeted MS Capture Cellular States and Enable Large-scale Comparison of Drug-induced Phenotypes. Abelin JG1, Patel J1, Lu X1, Feeney CM1, Fagbami L1, Creech AL1, Hu R1, Lam D1, Davison D1, Pino L1, Qiao JW1, Kuhn E1, Officer A1, Li J2, Abbatiello S1, Subramanian A1, Sidman R2, Snyder E3, Carr SA1, Jaffe JD4.
View Details (opens in a new window)
Mol Cell Proteomics. 2014 Jul;13(7):1690-704. doi: 10.1074/mcp.M113.036392. Epub 2014 Apr 9. Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mertins P1, Yang F2, Liu T2, Mani DR3, Petyuk VA2, Gillette MA3, Clauser KR3, Qiao JW3, Gritsenko MA2, Moore RJ2, Levine DA4, Townsend R5, Erdmann-Gilmore P5, Snider JE5, Davies SR5, Ruggles KV6, Fenyo D6, Kitchens RT5, Li S5, Olvera N4, Dao F4, Rodriguez H7, Chan DW8, Liebler D9, White F10, Rodland KD2, Mills GB11, Smith RD2, Paulovich AG12, Ellis M5, Carr SA1
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y9-98 (2+) | 6.4 | 4.7 | 5.3 | 7 | 5.5 | 7 | 9.5 | 7.2 | 8.8 | 15 | 15 | 15 |
| y9 (2+) | 5 | 4.8 | 5.8 | 6.9 | 4.6 | 8.6 | 8.5 | 6.6 | 10.4 | 15 | 15 | 15 |
| y8-98 (1+) | 5.6 | 5.8 | 7.8 | 6.8 | 7.3 | 8.4 | 8.8 | 9.3 | 11.5 | 15 | 15 | 15 |
| sum | 5.3 | 4.5 | 5.3 | 5.7 | 5 | 7.3 | 7.8 | 6.7 | 9 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Mol Cell Proteomics. 2016 May;15(5):1622-41. doi: 10.1074/mcp.M116.058354. Epub 2016 Feb 24. Reduced-representation Phosphosignatures Measured by Quantitative Targeted MS Capture Cellular States and Enable Large-scale Comparison of Drug-induced Phenotypes. Abelin JG1, Patel J1, Lu X1, Feeney CM1, Fagbami L1, Creech AL1, Hu R1, Lam D1, Davison D1, Pino L1, Qiao JW1, Kuhn E1, Officer A1, Li J2, Abbatiello S1, Subramanian A1, Sidman R2, Snyder E3, Carr SA1, Jaffe JD4.
View Details (opens in a new window)
Mol Cell Proteomics. 2014 Jul;13(7):1690-704. doi: 10.1074/mcp.M113.036392. Epub 2014 Apr 9. Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mertins P1, Yang F2, Liu T2, Mani DR3, Petyuk VA2, Gillette MA3, Clauser KR3, Qiao JW3, Gritsenko MA2, Moore RJ2, Levine DA4, Townsend R5, Erdmann-Gilmore P5, Snider JE5, Davies SR5, Ruggles KV6, Fenyo D6, Kitchens RT5, Li S5, Olvera N4, Dao F4, Rodriguez H7, Chan DW8, Liebler D9, White F10, Rodland KD2, Mills GB11, Smith RD2, Paulovich AG12, Ellis M5, Carr SA1
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y4 (1+) | 4 | 4 | 4.7 | 5.2 | 10.2 | 10.3 | 6.6 | 11 | 11.3 | 15 | 15 | 15 |
| y6 (1+) | 5.1 | 5 | 4.6 | 6.1 | 6 | 10 | 8 | 7.8 | 11 | 15 | 15 | 15 |
| y8-98 (1+) | 3.4 | 3.5 | 2.5 | 4.6 | 7.3 | 8.2 | 5.7 | 8.1 | 8.6 | 15 | 15 | 15 |
| sum | 3.5 | 3.6 | 3.1 | 3.7 | 7 | 8.8 | 5.1 | 7.9 | 9.3 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y12 (1+) | 57.7 | 17.3 | 13.6 | 56.8 | 37.3 | 25.5 | 81 | 41.1 | 28.9 | 15 | 15 | 15 |
| y7 (1+) | 38.7 | 16.6 | 13.7 | 37.9 | 38.1 | 22.9 | 54.2 | 41.6 | 26.7 | 15 | 15 | 15 |
| b5 (1+) | 51.3 | 16.1 | 13.3 | 47.2 | 40.6 | 25.3 | 69.7 | 43.7 | 28.6 | 15 | 15 | 15 |
| sum | 44.2 | 15.3 | 13.5 | 41.3 | 37.7 | 24.7 | 60.5 | 40.7 | 28.1 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y10 (1+) | 21.1 | 11.8 | 7.9 | 28.7 | 32.5 | 18.4 | 35.6 | 34.6 | 20 | 15 | 15 | 15 |
| y9 (1+) | 23.3 | 10.3 | 6.9 | 26.4 | 32.9 | 17.8 | 35.2 | 34.5 | 19.1 | 15 | 15 | 15 |
| sum | 21.8 | 10.7 | 7.1 | 26.3 | 32.7 | 18 | 34.2 | 34.4 | 19.3 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y10 (1+) | 24.9 | 10.1 | 7.4 | 29.2 | 23.4 | 8.9 | 38.4 | 25.5 | 11.6 | 15 | 15 | 15 |
| y8 (1+) | 22.2 | 8.8 | 7.6 | 24.2 | 23.7 | 9.8 | 32.8 | 25.3 | 12.4 | 15 | 15 | 15 |
| sum | 21.3 | 9.1 | 7.5 | 24.5 | 23.6 | 9.6 | 32.5 | 25.3 | 12.2 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y8 (1+) | 17.9 | 16 | 11.6 | 21.7 | 33.4 | 16.2 | 28.1 | 37 | 19.9 | 15 | 15 | 15 |
| y7 (1+) | 29.4 | 16.9 | 11.5 | 33.7 | 33.1 | 16.8 | 44.7 | 37.2 | 20.4 | 15 | 15 | 15 |
| y6 (1+) | 23.5 | 15.1 | 10.8 | 26.1 | 33.6 | 15.9 | 35.1 | 36.8 | 19.2 | 15 | 15 | 15 |
| y4 (1+) | 29.7 | 15.3 | 11.3 | 34.3 | 34.4 | 16.5 | 45.4 | 37.6 | 20 | 15 | 15 | 15 |
| sum | 23 | 15.5 | 11.3 | 26.5 | 33.5 | 16.2 | 35.1 | 36.9 | 19.8 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y6 (1+) | 22.5 | 12.8 | 13.5 | 23.9 | 15.5 | 13.8 | 32.8 | 20.1 | 19.3 | 16 | 15 | 16 |
| y8 (1+) | 19 | 11.8 | 16.7 | 20 | 13.8 | 15 | 27.6 | 18.2 | 22.4 | 16 | 15 | 16 |
| sum | 20.2 | 12.2 | 12.2 | 22.2 | 14.5 | 11.6 | 30 | 18.9 | 16.8 | 16 | 15 | 16 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y6 (1+) | 34.6 | 13.6 | 8.5 | 44.4 | 15.7 | 10.6 | 56.3 | 20.8 | 13.6 | 16 | 15 | 17 |
| y4 (1+) | 36.5 | 9.4 | 8.9 | 37.9 | 16.9 | 15.3 | 52.6 | 19.3 | 17.7 | 16 | 15 | 17 |
| b3 (1+) | 27.8 | 11.2 | 8 | 22.9 | 13.3 | 9.5 | 36 | 17.4 | 12.4 | 16 | 15 | 17 |
| sum | 25.6 | 9 | 4.8 | 25.3 | 12.9 | 9.8 | 36 | 15.7 | 10.9 | 16 | 15 | 17 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y6 (1+) | 15.7 | 8 | 21 | 16.5 | 9.2 | 21.4 | 22.8 | 12.2 | 30 | 16 | 15 | 17 |
| y20 (3+) | 13.2 | 5.9 | 19.1 | 10.8 | 6.6 | 21.4 | 17.1 | 8.9 | 28.7 | 16 | 15 | 17 |
| sum | 13 | 5.9 | 18.9 | 10.6 | 6.5 | 21.3 | 16.8 | 8.8 | 28.5 | 16 | 15 | 17 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y19 (3+) | 32.1 | 13.7 | 39.1 | 29.4 | 24.6 | 41.2 | 43.5 | 28.2 | 56.8 | 16 | 15 | 16 |
| y20 (3+) | 15.2 | 10 | 37.5 | 24.1 | 19.7 | 41.5 | 28.5 | 22.1 | 55.9 | 16 | 15 | 16 |
| sum | 11.7 | 9.4 | 37.5 | 19.3 | 20.3 | 41.4 | 22.6 | 22.4 | 55.9 | 16 | 15 | 16 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y7 (1+) | 51.2 | 22.1 | 13.4 | 54.2 | 22.9 | 17.9 | 74.6 | 31.8 | 22.4 | 16 | 15 | 17 |
| y21 (2+) | 23.7 | 13.1 | 7.9 | 22.3 | 18.5 | 7.2 | 32.5 | 22.7 | 10.7 | 16 | 15 | 17 |
| b5 (1+) | 47.9 | 18.9 | 10.2 | 44.6 | 17.5 | 11.9 | 65.4 | 25.8 | 15.7 | 16 | 15 | 17 |
| sum | 19.9 | 12 | 7.2 | 20.5 | 16.5 | 6.9 | 28.6 | 20.4 | 10 | 16 | 15 | 17 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y22 (2+) | 27.9 | 13.5 | 28.2 | 27.3 | 17.9 | 27.4 | 39 | 22.4 | 39.3 | 16 | 15 | 16 |
| b5 (1+) | 14.8 | 15.5 | 29.4 | 13.5 | 17.2 | 28.5 | 20 | 23.2 | 40.9 | 16 | 15 | 16 |
| y7 (1+) | 15.3 | 13.4 | 25.7 | 22.9 | 14.6 | 26.4 | 27.5 | 19.8 | 36.8 | 16 | 15 | 16 |
| sum | 14.3 | 12.8 | 26.4 | 14.9 | 14.6 | 26.4 | 20.7 | 19.4 | 37.3 | 16 | 15 | 16 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y4 (1+) | 14.3 | 11.6 | 9.8 | 16.2 | 13.1 | 10 | 21.6 | 17.5 | 14 | 16 | 15 | 16 |
| y6 (1+) | 24 | 15 | 7.8 | 27.8 | 17.3 | 8.3 | 36.7 | 22.9 | 11.4 | 16 | 15 | 16 |
| y11 (1+) | 18.2 | 11.8 | 17 | 17 | 16.1 | 20.7 | 24.9 | 20 | 26.8 | 16 | 15 | 16 |
| sum | 17.2 | 12.5 | 8.9 | 18.6 | 15 | 9.8 | 25.3 | 19.5 | 13.2 | 16 | 15 | 16 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y11 (1+) | 55.6 | 19.8 | 15.2 | 60.8 | 27.2 | 17.6 | 82.4 | 33.6 | 23.3 | 16 | 15 | 17 |
| y6 (1+) | 27.5 | 11.5 | 15.8 | 37.2 | 34.3 | 19.4 | 46.3 | 36.2 | 25 | 16 | 15 | 17 |
| y4 (1+) | 48.4 | 16.3 | 17.1 | 54.8 | 22.9 | 17.7 | 73.1 | 28.1 | 24.6 | 16 | 15 | 17 |
| sum | 30.2 | 10.1 | 13.4 | 36.1 | 22.8 | 14.9 | 47.1 | 24.9 | 20 | 16 | 15 | 17 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y10 (1+) | 38 | 20.4 | 16.7 | 33.9 | 45.3 | 28.3 | 50.9 | 49.7 | 32.9 | 15 | 15 | 15 |
| y8 (1+) | 48.2 | 18.8 | 16.6 | 43.6 | 46 | 29.5 | 65 | 49.7 | 33.8 | 15 | 15 | 15 |
| y7 (1+) | 42.2 | 18.2 | 16.1 | 36.4 | 44.6 | 29 | 55.7 | 48.2 | 33.2 | 15 | 15 | 15 |
| sum | 41.6 | 18.8 | 16.3 | 36 | 45.1 | 28.9 | 55 | 48.9 | 33.2 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
mTORC1-driven protein translation correlates with clinical benefit of capivasertib within a genetically preselected cohort of PIK3CA-altered tumours. Constance A Sobsey, Bjoern C Froehlich, Georgia Mitsa, Sahar Ibrahim, Robert Popp, Rene P Zahedi, Elza C de Bruin, Christoph H Borchers, Gerald Batist
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| b3 (1+) | 17 | 8.9 | 6.8 | 16.6 | 10.6 | 5.7 | 23.8 | 13.8 | 8.9 | 16 | 16 | 17 |
| y10 (1+) | 23.1 | 9.9 | 6.8 | 19.6 | 9.2 | 7.8 | 30.3 | 13.5 | 10.3 | 16 | 16 | 17 |
| y5 (1+) | 15.1 | 9.5 | 6.4 | 17.2 | 9.5 | 4.8 | 22.9 | 13.4 | 8 | 16 | 16 | 17 |
| y8 (1+) | 17.4 | 7.7 | 8.4 | 18.6 | 6 | 8.9 | 25.5 | 9.8 | 12.2 | 16 | 16 | 17 |
| y8 (2+) | 34.5 | 8.8 | 8.2 | 42.7 | 6.7 | 6.2 | 54.9 | 11.1 | 10.3 | 16 | 16 | 17 |
| sum | 7.4 | 3.4 | 2.9 | 7.7 | 3.4 | 4 | 10.7 | 4.8 | 4.9 | 16 | 16 | 17 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| b6 (1+) | 48.6 | 13.5 | 12 | 45.5 | 40.5 | 23.1 | 66.6 | 42.7 | 26 | 14 | 14 | 14 |
| b5 (1+) | 40.6 | 12.9 | 12.5 | 33.5 | 41.9 | 24 | 52.6 | 43.8 | 27.1 | 14 | 14 | 14 |
| y4 (1+) | 77.5 | 27.8 | 14.2 | 98.6 | 34.4 | 22.1 | 125.4 | 44.2 | 26.3 | 14 | 14 | 14 |
| y7 (1+) | 32.3 | 12.4 | 12.6 | 35.5 | 32.9 | 22.3 | 48 | 35.2 | 25.6 | 14 | 14 | 14 |
| y12 (1+) | 45.5 | 17.4 | 11.5 | 49.7 | 38.8 | 22.7 | 67.4 | 42.5 | 25.4 | 14 | 14 | 14 |
| sum | 38.1 | 13.5 | 12 | 36.5 | 38.4 | 22.9 | 52.8 | 40.7 | 25.9 | 14 | 14 | 14 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y10 (1+) | 9.3 | 4.4 | 2.6 | 9 | 4.9 | 3.3 | 12.9 | 6.6 | 4.2 | 15 | 15 | 15 |
| y11 (1+) | 10.4 | 8.4 | 6 | 10.6 | 8.7 | 7.2 | 14.8 | 12.1 | 9.4 | 15 | 15 | 15 |
| y12 (1+) | 6.6 | 4.4 | 2.2 | 6.3 | 4.6 | 3.8 | 9.1 | 6.4 | 4.4 | 15 | 15 | 15 |
| y9 (1+) | 4.9 | 4.7 | 2.5 | 5.2 | 5.3 | 2.9 | 7.1 | 7.1 | 3.8 | 15 | 15 | 15 |
| sum | 3.4 | 3.9 | 1.5 | 3.8 | 4.7 | 2.8 | 5.1 | 6.1 | 3.2 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| b3 (1+) | 22 | 7.4 | 7.9 | 22.4 | 23.9 | 9 | 31.4 | 25 | 12 | 14 | 14 | 14 |
| y5 (1+) | 20 | 6.3 | 7.7 | 21.3 | 23.3 | 9.5 | 29.2 | 24.1 | 12.2 | 14 | 14 | 14 |
| y8 (1+) | 21.7 | 7.1 | 8.1 | 26.3 | 24.6 | 9.4 | 34.1 | 25.6 | 12.4 | 14 | 14 | 14 |
| y10 (1+) | 24.2 | 7 | 8.3 | 28.6 | 24.1 | 9.2 | 37.5 | 25.1 | 12.4 | 14 | 14 | 14 |
| sum | 21.4 | 6.8 | 7.9 | 24 | 24.1 | 9.2 | 32.2 | 25 | 12.1 | 14 | 14 | 14 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y4 (1+) | 23.2 | 14.2 | 12 | 27.5 | 34.1 | 15 | 36 | 36.9 | 19.2 | 14 | 14 | 14 |
| y6 (1+) | 22.1 | 12.3 | 11.9 | 26 | 32.6 | 16.1 | 34.1 | 34.8 | 20 | 14 | 14 | 14 |
| y7 (1+) | 23.1 | 13.4 | 12.4 | 29 | 32 | 15.9 | 37.1 | 34.7 | 20.2 | 14 | 14 | 14 |
| y8 (1+) | 19 | 14 | 12.5 | 22.9 | 33.1 | 15.4 | 29.8 | 35.9 | 19.8 | 14 | 14 | 14 |
| y10 (1+) | 16.3 | 13.5 | 12.6 | 25.8 | 33.1 | 14.5 | 30.5 | 35.7 | 19.2 | 14 | 14 | 14 |
| sum | 20.2 | 13.3 | 12.2 | 24.9 | 32.9 | 15.4 | 32.1 | 35.5 | 19.6 | 14 | 14 | 14 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y11 (1+) | 32.3 | 8.3 | 5 | 18.3 | 10.1 | 5.5 | 37.1 | 13.1 | 7.4 | 15 | 15 | 15 |
| y10 (1+) | 24.3 | 9.3 | 6.5 | 10 | 9.5 | 8.4 | 26.3 | 13.3 | 10.6 | 15 | 15 | 15 |
| y8 (1+) | 25.8 | 8.8 | 6.8 | 6.3 | 6.1 | 6.5 | 26.6 | 10.7 | 9.4 | 15 | 15 | 15 |
| y6 (1+) | 18.9 | 5.9 | 1.8 | 6.7 | 4.8 | 2.5 | 20.1 | 7.6 | 3.1 | 15 | 15 | 15 |
| y4 (1+) | 20.6 | 5.6 | 3 | 8.7 | 4.6 | 3.7 | 22.4 | 7.2 | 4.8 | 15 | 15 | 15 |
| sum | 21.2 | 5.5 | 2.7 | 4.7 | 4.3 | 3.4 | 21.7 | 7 | 4.3 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y18 (2+) | 12.4 | 6.7 | 3.4 | 12.3 | 7 | 4 | 17.5 | 9.7 | 5.2 | 15 | 15 | 15 |
| y19 (2+) | 20.4 | 6.8 | 6.7 | 20.3 | 8.3 | 8.4 | 28.8 | 10.7 | 10.7 | 15 | 15 | 15 |
| y20 (2+) | 4.1 | 4.9 | 4.7 | 4.6 | 6.7 | 4.9 | 6.2 | 8.3 | 6.8 | 15 | 15 | 15 |
| y4 (1+) | 10.9 | 4.1 | 3.6 | 13.9 | 4.7 | 3.8 | 17.7 | 6.2 | 5.2 | 15 | 15 | 15 |
| y6 (1+) | 15.8 | 5.1 | 9.4 | 14.6 | 5.3 | 9.2 | 21.5 | 7.4 | 13.2 | 15 | 15 | 15 |
| sum | 5.6 | 2.5 | 2.4 | 5.8 | 4.1 | 3.2 | 8.1 | 4.8 | 4 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y7 (1+) | 8.3 | 3.7 | 4.6 | 9 | 4.8 | 5.3 | 12.2 | 6.1 | 7 | 15 | 15 | 15 |
| y6 (1+) | 3 | 2.5 | 2.1 | 3.2 | 2.3 | 2.4 | 4.4 | 3.4 | 3.2 | 15 | 15 | 15 |
| y20-98 (2+) | 3.9 | 2.5 | 3.4 | 3.9 | 2.7 | 4.4 | 5.5 | 3.7 | 5.6 | 15 | 15 | 15 |
| y19 (2+) | 9.6 | 6.3 | 2.8 | 10.3 | 5.7 | 2.7 | 14.1 | 8.5 | 3.9 | 15 | 15 | 15 |
| b11 (3+) | 7.2 | 6.5 | 2 | 6.9 | 6.5 | 3.7 | 10 | 9.2 | 4.2 | 15 | 15 | 15 |
| sum | 2.7 | 2.9 | 1.6 | 2.6 | 2.6 | 2.9 | 3.7 | 3.9 | 3.3 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y20 (3+) | 4.1 | 3.9 | 1.7 | 4.2 | 6 | 3.7 | 5.9 | 7.2 | 4.1 | 15 | 15 | 15 |
| y21 (3+) | 13.2 | 7.5 | 4.1 | 12.5 | 8.3 | 5.1 | 18.2 | 11.2 | 6.5 | 15 | 15 | 15 |
| y2 (1+) | 20.7 | 6.6 | 4.9 | 24.4 | 7.8 | 5.3 | 32 | 10.2 | 7.2 | 15 | 15 | 15 |
| y6 (1+) | 10.2 | 5.1 | 4.4 | 10.3 | 6.7 | 4.9 | 14.5 | 8.4 | 6.6 | 15 | 15 | 15 |
| sum | 3.1 | 4 | 1.7 | 3.4 | 6.1 | 3.6 | 4.6 | 7.3 | 4 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y8 (1+) | 26.8 | 8.7 | 11.9 | 24.3 | 12.6 | 12.5 | 36.2 | 15.3 | 17.3 | 15 | 15 | 15 |
| y7 (1+) | 7.8 | 4.4 | 5.2 | 5.6 | 4.9 | 5.1 | 9.6 | 6.6 | 7.3 | 15 | 15 | 15 |
| y21-98 (2+) | 5.3 | 5.8 | 5.9 | 6.9 | 6.7 | 6.6 | 8.7 | 8.9 | 8.9 | 15 | 15 | 15 |
| y20 (2+) | 13.6 | 6.3 | 6.5 | 11.3 | 4.6 | 8.8 | 17.7 | 7.8 | 10.9 | 15 | 15 | 15 |
| b5 (1+) | 14.2 | 4.9 | 5.3 | 14.3 | 5.7 | 6.4 | 20.2 | 7.5 | 8.3 | 15 | 15 | 15 |
| sum | 6 | 3.9 | 3.4 | 5.4 | 4.2 | 3.7 | 8.1 | 5.7 | 5 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y21 (3+) | 3.5 | 4.1 | 2.1 | 4.3 | 5.3 | 3.2 | 5.5 | 6.7 | 3.8 | 15 | 15 | 15 |
| y22 (3+) | 20.3 | 4.8 | 2.8 | 27.1 | 6.9 | 4.3 | 33.9 | 8.4 | 5.1 | 15 | 15 | 15 |
| y23 (3+) | 16.7 | 7.3 | 4.2 | 20.7 | 7.9 | 4.6 | 26.6 | 10.8 | 6.2 | 15 | 15 | 15 |
| y21 (2+) | 14.3 | 10.2 | 7.9 | 15.1 | 10.1 | 9.5 | 20.8 | 14.4 | 12.4 | 15 | 15 | 15 |
| y7 (1+) | 6.1 | 6.1 | 2.9 | 8.6 | 7.1 | 3.8 | 10.5 | 9.4 | 4.8 | 15 | 15 | 15 |
| sum | 2.2 | 3.5 | 1.6 | 3.6 | 5 | 2.9 | 4.2 | 6.1 | 3.3 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y8 (1+) | 16.6 | 9.4 | 5.5 | 14.8 | 8.1 | 4.9 | 22.2 | 12.4 | 7.4 | 15 | 15 | 15 |
| y7 (1+) | 17.2 | 8.9 | 3.1 | 17.5 | 6.3 | 5.7 | 24.5 | 10.9 | 6.5 | 15 | 15 | 15 |
| y6 (1+) | 15.2 | 8.7 | 2.6 | 8.9 | 4.1 | 4.2 | 17.6 | 9.6 | 4.9 | 15 | 15 | 15 |
| y4 (1+) | 16.1 | 8.2 | 2.1 | 6.8 | 5.9 | 2.9 | 17.5 | 10.1 | 3.6 | 15 | 15 | 15 |
| y11 (1+) | 17.7 | 9.8 | 4.7 | 10.3 | 8.3 | 3.9 | 20.5 | 12.8 | 6.1 | 15 | 15 | 15 |
| sum | 15.4 | 8.1 | 2.2 | 6.5 | 5.3 | 3.1 | 16.7 | 9.7 | 3.8 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y14 (2+) | 9.5 | 4.7 | 3.9 | 9.1 | 5.5 | 5 | 13.2 | 7.2 | 6.3 | 15 | 15 | 15 |
| y16 (2+) | 14.3 | 4.8 | 3.2 | 15 | 5.7 | 4 | 20.7 | 7.5 | 5.1 | 15 | 15 | 15 |
| y4 (1+) | 9.1 | 3.7 | 2.8 | 9.1 | 4.5 | 3.2 | 12.9 | 5.8 | 4.3 | 15 | 15 | 15 |
| y6 (1+) | 12.7 | 6.1 | 5.4 | 17.1 | 7.5 | 5.7 | 21.3 | 9.7 | 7.9 | 15 | 15 | 15 |
| y8 (1+) | 20.7 | 8.8 | 6.4 | 17.6 | 5.2 | 7.8 | 27.2 | 10.2 | 10.1 | 15 | 15 | 15 |
| sum | 4.8 | 1.6 | 2.4 | 5.6 | 3.2 | 3.1 | 7.4 | 3.6 | 3.9 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. Cell Reports Methods doi: 10.1016/j.crmeth.2021.100015.
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y3 (1+) | 43.8 | 12.6 | 15.9 | 42.3 | 44.1 | 26.7 | 60.9 | 45.9 | 31.1 | 14 | 14 | 14 |
| y7 (1+) | 44.9 | 14.9 | 15.9 | 39.3 | 45.7 | 26.8 | 59.7 | 48.1 | 31.2 | 14 | 14 | 14 |
| y8 (1+) | 42.4 | 15.5 | 16.4 | 39.3 | 47.1 | 27.3 | 57.8 | 49.6 | 31.8 | 14 | 14 | 14 |
| y10 (1+) | 37.8 | 14.5 | 17.4 | 34.4 | 45.2 | 27.4 | 51.1 | 47.5 | 32.5 | 14 | 14 | 14 |
| sum | 42.7 | 14.2 | 16.2 | 38.3 | 45.3 | 27 | 57.4 | 47.5 | 31.5 | 14 | 14 | 14 |
Data source: Panorama
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| b8 (1+) | 13.4 | 7.5 | 11.9 | 18.2 | 11.8 | 15.8 | 22.6 | 14 | 19.8 | 15 | 15 | 15 |
| b9 (1+) | 13.7 | 8.6 | 11.7 | 18 | 12 | 16 | 22.6 | 14.8 | 19.8 | 15 | 15 | 15 |
| y7 (1+) | 12 | 7.1 | 11.3 | 18.1 | 11 | 15.7 | 21.7 | 13.1 | 19.3 | 15 | 15 | 15 |
| sum | 12.6 | 7.6 | 11.5 | 17.9 | 11.4 | 15.8 | 21.9 | 13.7 | 19.5 | 15 | 15 | 15 |
Data source: Panorama
Data source: Panorama
Broad Institute-Stress Pathway Panel
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y7 (1+) | 26.2 | 3.1 | 4.9 | 36.1 | 4.1 | 5.8 | 44.6 | 5.1 | 7.6 | 15 | 15 | 15 |
| y6 (1+) | 14.1 | 3.7 | 4.4 | 23.4 | 3.3 | 4.9 | 27.3 | 5 | 6.6 | 15 | 15 | 15 |
| y4 (1+) | 50.7 | 4.4 | 4.4 | 57.1 | 4.4 | 5.6 | 76.4 | 6.2 | 7.1 | 15 | 15 | 15 |
| sum | 6.4 | 3.3 | 4.3 | 21 | 3.4 | 5 | 22 | 4.7 | 6.6 | 15 | 15 | 15 |
")
.appendTo(all_in_one_graph)
.click(function (e) {
e.preventDefault();
all_in_one_plot.pan(offset);
});
}
addArrow("left", 55, 40, {left: -100});
addArrow("right", 25, 40, {left: 100});
addArrow("up", 40, 25, {top: -100});
addArrow("down", 40, 55, {top: 100});
// Disable the mouse wheel functionality for panning and zooming
$('#all_in_one_graph canvas.flot-overlay').unmousewheel();
$(all_in_one_graph).bind("plotclick", function (event, pos, item) {
// Splice Junctions
// http://www.uniprot.org/uniprot/P04626#section_features
if ((item != null) && (item.series.data[0][3] != null) && (item.series.data[0][3] == 'splice_junction')) {
var url = 'http://www.uniprot.org/uniprot/' + uniprot_id + '#section_features';
window.open(url, '_blank');
}
// Isoforms
if ((item != null) && (item.series.data[0][4] != null) && (item.series.data[0][4] == 'isoform')) {
var url = 'http://www.uniprot.org/uniprot/' + item.series.data[item.dataIndex][3];
window.open(url, '_blank');
}
// SNPs
if ((item != null) && (item.series.data[0][3] != null) && (item.series.data[0][3] == 'snp')) {
var url = 'http://www.uniprot.org/blast/?about=' + uniprot_id + '[' + item.datapoint[0] + ']';
window.open(url, '_blank');
}
// MRM Assays
if ((item != null) && (item.series.data[0][4] != null) && (item.series.data[0][4] == 'mrm_assay')) {
var this_peptide_sequence = item.series.data[item.dataIndex][3];
var this_protein_id = item.series.data[item.dataIndex][5];
var div_id = '.' + this_protein_id;
// Change our States (URL, title in title bar)
History.replaceState({state: 1}, "MTOR, CPTAC-" + this_protein_id + " - CPTAC Assay Portal", "CPTAC-" + this_protein_id);
// Scroll to assays area
scrollToAnchor('assay_details_anchor');
$('.assay-details-wrapper').hide();
$('#preloader_loading_assay_details').fadeIn(500);
$('#preloader_loading_assay_details').hide();
$(div_id).fadeIn(300);
// Load Disqus commenting
//loadDisqus($('#comments_container_' + this_protein_id), this_peptide_sequence, 'http://assays.cancer.gov/CPTAC-1360/#!' + this_peptide_sequence);
}
});
///////////////////////////////////////////////////////////
// [BEGIN] Highlighted Peptide Sequence Links ///////////////
// Use sequence values from the 'genes_distinct' array
var mouseY;
var mouseX;
$(document).mousemove(function (e) {
mouseX = e.pageX;
mouseY = e.pageY;
});
var starts = JSON.parse('[{"peptide_sequence":"KLHVSTINLQK","manage":1360},{"peptide_sequence":"LHVSTINLQK","manage":1361},{"peptide_sequence":"DLELAVPGTYDPNQPIIR","manage":5753},{"peptide_sequence":"IQSIAPSLQVITSK","manage":5752},{"peptide_sequence":"LFDAPEAPLPSR","manage":5755},{"peptide_sequence":"LTESLDFTDYASR","manage":5754},{"peptide_sequence":"TDSYSAGQSVEILDGVELGEPAHK","manage":5798},{"peptide_sequence":"TDSYSAGQSVEILDGVELGEPAHK","manage":5797},{"peptide_sequence":"TGTTVPESIHSFIGDGLVKPEALNK","manage":5794},{"peptide_sequence":"TGTTVPESIHSFIGDGLVKPEALNK","manage":5793},{"peptide_sequence":"TGTTVPESIHSFIGDGLVKPEALNKK","manage":5796},{"peptide_sequence":"TGTTVPESIHSFIGDGLVKPEALNKK","manage":5795},{"peptide_sequence":"TRTDSYSAGQSVEILDGVELGEPAHK","manage":5800},{"peptide_sequence":"TRTDSYSAGQSVEILDGVELGEPAHK","manage":5799},{"peptide_sequence":"VLGLLGALDPYK","manage":5756},{"peptide_sequence":"LFDAPEAPLPSR","manage":6111},{"peptide_sequence":"DLELAVPGTYDPNQPIIR","manage":5563},{"peptide_sequence":"IQSIAPSLQVITSK","manage":5421},{"peptide_sequence":"LFDAPEAPLPSR","manage":5561},{"peptide_sequence":"LTESLDFTDYASR","manage":5562},{"peptide_sequence":"TDSYSAGQSVEILDGVELGEPAHK","manage":5711},{"peptide_sequence":"TDSYSAGQSVEILDGVELGEPAHK","manage":5423},{"peptide_sequence":"TGTTVPESIHSFIGDGLVKPEALNK","manage":5709},{"peptide_sequence":"TGTTVPESIHSFIGDGLVKPEALNK","manage":5424},{"peptide_sequence":"TGTTVPESIHSFIGDGLVKPEALNKK","manage":5710},{"peptide_sequence":"TGTTVPESIHSFIGDGLVKPEALNKK","manage":5425},{"peptide_sequence":"TRTDSYSAGQSVEILDGVELGEPAHK","manage":5712},{"peptide_sequence":"TRTDSYSAGQSVEILDGVELGEPAHK","manage":5422},{"peptide_sequence":"VLGLLGALDPYK","manage":5560},{"peptide_sequence":"AVLALHQDLFSLAQQCIDK","manage":3134},{"peptide_sequence":"DASAVSLSESK","manage":3133}]');
var last_clicked = false;
$.each(starts, function (index, starts_data) {
// On click event for peptide sequence links in the gene sequence
var this_peptide_sequence = starts_data.peptide_sequence;
var this_protein_id = starts_data.manage;
var div_id = '.' + this_protein_id;
var clickable_class = 'seq-' + this_peptide_sequence;
$('.' + clickable_class).on('click', function () {
$("rect, line, .close").tooltip();
if (last_clicked != this_peptide_sequence) {
$('.detail-modal').attr('style', 'display: none');
last_clicked = false;
}
var div_height = $('.all-details-' + this_peptide_sequence).height();
var offset = (div_height > 25) ? 450 : 390;
$('.all-details-' + this_peptide_sequence).css({'top': mouseY - offset}).fadeIn('fast');
$('.detail-modal .close').on('click', function () {
$('.detail-modal').fadeOut('fast');
});
});
var detail_link_class = this_peptide_sequence + '-' + this_protein_id;
$('.protein-sequence').on('click', '.' + detail_link_class, function () {
// close the pop up
$('.detail-modal').fadeOut('fast');
// Change our States (URL, title in title bar)
History.replaceState({state: 1}, "MTOR, CPTAC-" + this_protein_id + " - CPTAC Assay Portal", "CPTAC-" + this_protein_id);
// Scroll to assays area
scrollToAnchor('assay_details_anchor');
$('.assay-details-wrapper').hide();
$('#preloader_loading_assay_details').fadeIn(500);
$('#preloader_loading_assay_details').hide();
$(div_id).fadeIn(300);
// Load Disqus commenting
//loadDisqus($('#comments_container_' + this_protein_id), this_peptide_sequence, 'http://assays.cancer.gov/CPTAC-1360/#!' + this_peptide_sequence);
});
});
// $("rect, line, .peptide_highlight").tooltip({
// 'container': 'body',
// 'placement': 'top'
// });
// [END] Highlighted Peptide Sequence Links ///////////////
// Tooltips on hover of data points
var previousPoint = null;
$(all_in_one_graph).bind("plothover", function (event, pos, item) {
if (item) {
document.body.style.cursor = 'pointer';
if (previousPoint != item.dataIndex) {
previousPoint = item.dataIndex;
$("#tooltip").remove();
showTooltip(item.pageX, item.pageY, item.series.data[item.dataIndex][2]);
}
} else {
document.body.style.cursor = 'default';
$("#tooltip").remove();
previousPoint = null;
}
});
// Pop-out entire sequence
$('div.sequence').on('mouseenter', '.protein-sequence', function (event) {
$(this).attr('style', 'overflow: visible;');
$('table.sequence').addClass('sequence_table_shadow');
});
$('div.sequence').on('mouseleave', '.protein-sequence', function (event) {
$(this).attr('style', 'overflow: hidden;');
$('table.sequence').removeClass('sequence_table_shadow');
$('.detail-modal').attr('style', 'display: none');
});
// Tooltips
$('.span4 img, .chart-legend, .chart-legend-text').tooltip();
// Show the Assay details for the page id we're on
var details_div_id = $('#outer-wrapper .1360');
$(details_div_id).show();
//loadDisqus($('#comments_container_1360'), 'KLHVSTINLQK', 'http://assays.cancer.gov/CPTAC-1360/#!KLHVSTINLQK');
// History.js
(function (window, undefined) {
// Bind to StateChange Event
History.Adapter.bind(window, 'statechange', function () { // Note: We are using statechange instead of popstate
var State = History.getState(); // Note: We are using History.getState() instead of event.state
});
})(window);
$.ajax({
type: "GET"
, dataType: "html"
, url: "/assays/get_protein_map_svg"
, data: ({uniprot_ac_id: uniprot_id})
, success: function (svg_return) {
d3.select("#proteincartoon").html(svg_return);
}
});
$('#proteincartoon').click(function () {
var win = window.open('http://www.phosphosite.org/uniprotAccAction.do?id=' + uniprot_id, '_blank');
win.focus();
});
});
// FUNCTIONS ///////////////
function scrollToAnchor(aid) {
var aTag = $("a[name='" + aid + "']");
$('html,body').animate({scrollTop: aTag.offset().top}, 'slow');
}
function showTooltip(x, y, contents) {
$("Table data unavailable
'; // Display the preloaders $.each(genes, function (index, gene) { $('div.span12.' + gene.peptide_sequence + '_' + gene.laboratory_abbreviation + ' .loc_lloq_preloader_loading').show(); }); // Send the request via AJAX $.ajax({ url: "/assays/get_plots_table_data" , dataType: "json" , type: "post" , data: {genes: JSON.stringify(genes)} , success: function (data) { if (data) { $.each(data, function (index, single_gene_data) { /* * Build out the LOC/LOQ data table */ if (single_gene_data.lod_loq_comparison_data[0].length) { var crude = (single_gene_data.peptide_standard_purity_types_id == 3) ? true : false; var peptide_sequence = single_gene_data.lod_loq_comparison_data[0][0].peptide; var lod_loq_units = single_gene_data.lod_loq_comparison_data[0][0].lod_loq_units; var crude_style = (crude) ? 'class="crude-header"' : ''; var lod_loq_units_note = (crude) ? 'Response Curves Data Unavailable
'); }); } }); } } }); }
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