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. 1996 Jan;142(1):163–171. doi: 10.1093/genetics/142.1.163

Mutations Modulating Raf Signaling in Drosophila Eye Development

B J Dickson 1, A van-der-Straten 1, M Dominguez 1, E Hafen 1
PMCID: PMC1206944  PMID: 8770593

Abstract

The R7 fate is specified during Drosophila eye development by an inductive signal transduced intracellularly via the Raf kinase. We have performed a genetic screen for dominant mutations that alter the efficiency with which cells respond to a constitutively activated Raf kinase. Such mutations may affect genes involved in signal transduction downstream of Raf. We have isolated 44 mutations that define eight genes. One of these encodes a mitogen-activated protein kinase homologue; another is a putative target gene of this signaling pathway. We present the results of this screen in detail, as well as a preliminary genetic analysis of the six loci still to be characterized molecularly.

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Selected References

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