Skip to main page content
U.S. flag
See More

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Aug;8(8):2381-6.
doi: 10.1002/j.1460-2075.1989.tb08367.x.

The spatial and temporal expression pattern of sevenless is exclusively controlled by gene-internal elements

K Basler  1 , P Siegrist, E Hafen
Affiliations

The spatial and temporal expression pattern of sevenless is exclusively controlled by gene-internal elements

K Basler et al. EMBO J. 1989 Aug.

Abstract

The sevenless gene controls the fate of a single photoreceptor cell type in the developing eye of Drosophila. Its RNA and protein accumulate transiently in a subpopulation of cells in the developing eye imaginal disc. We have used P-element transformation with different minigenes and marker gene constructs to identify cis-acting regulatory regions required for the complex sevenless expression pattern. Our results indicate that the upstream region of the sevenless gene is devoid of any detectable regulatory elements and that sequences located 3' to the transcription start site are sufficient to promote the sevenless expression pattern. These gene-internal sequences function in both orientations on heterologous promoters, also when placed at the 3' end of a lacZ reporter gene.

PubMed Disclaimer

References

    1. Trends Genet. 1988 Mar;4(3):74-9 - PubMed
    1. Cell. 1984 Sep;38(2):391-8 - PubMed
    1. Science. 1987 Apr 3;236(4797):55-63 - PubMed
    1. EMBO J. 1986 Jul;5(7):1653-8 - PubMed
    1. Cell. 1985 Jul;41(3):885-97 - PubMed

Publication types

MeSH terms

LinkOut - more resources