Nanoparticles articles from across Nature Portfolio

A synthetic peptide nanoparticle and microfluidic chip enable sterility testing of cell- and gene-based therapeutics in under 18 hours, bridging a long-standing safety gap for biopharmaceutical products that cannot undergo terminal sterilization and have limited shelf life.

An engineered nanobody enables modular display of multiple viral epitopes onto a single protein-based nanoparticle, leading to broad-spectrum immunization.

Metal nanoparticles have been made with polymer patches accurately placed on their surfaces — enabling them to self-assemble into otherwise inaccessible 3D structures.

Polymer-coated liposomes specifically target and deliver interleukin-12 to metastatic ovarian cancer, strongly sensitizing the tumours to combination therapy with immune checkpoint inhibitors.

A ROS-chemotactic antioxidative nanoscavenger prevents acute thrombosis by protecting vascular endothelial cells from oxidative stress, while circumventing the bleeding risk associated with current clinical antithrombotic drugs.

Electron-induced light, cathodoluminescence, enables nanoscale optical analysis across disciplines. Here, the authors achieve multicolor cathodoluminescence imaging of sub-15-nm lanthanide nanoparticles and demonstrate its application for bioimaging.

The dynamic behavior of supported metal nanoparticles under reaction conditions plays a crucial role in determining their catalytic performance. Here, time-resolved XRD, PDF, and modulation techniques provide direct evidence of hydrogen-induced breathing and detachment of Pt nanoparticles from an alumina support, uncovering reversible, size-dependent dynamics in both gas and liquid phases.

Concerns associated with the immunogenicity of mRNA lipid nanoparticles containing polyethylene glycol (PEG) are inspiring the development of PEG alternatives.

A synthetic peptide nanoparticle and microfluidic chip enable sterility testing of cell- and gene-based therapeutics in under 18 hours, bridging a long-standing safety gap for biopharmaceutical products that cannot undergo terminal sterilization and have limited shelf life.

An engineered nanobody enables modular display of multiple viral epitopes onto a single protein-based nanoparticle, leading to broad-spectrum immunization.

Metal nanoparticles have been made with polymer patches accurately placed on their surfaces — enabling them to self-assemble into otherwise inaccessible 3D structures.

High-entropy materials offer an exciting realm of possibilities for material discovery and application; however, their nanoscale synthesis is limited by the need for specialized equipment. Now, a simple synthetic strategy employing wax candles enables production of these compositionally complex nanomaterials.