Microbiome articles from across Nature Portfolio

Microbiota-derived metabolites shape intestinal health by modulating T cell metabolism. Li et al. show that indole-3-propionic acid (IPA) promotes mitochondrial respiration to suppress pro-inflammatory T cell differentiation, thereby alleviating inflammatory bowel disease in humans and mice.

Drought reshapes microbial communities around wheat roots. Synthetic microbial communities constructed from single-cell-sorted drought-tolerant bacteria provide a promising strategy to enhance crop resilience.

Here, the authors systematically map metaproteomic responses of ex vivo human gut microbiota to common therapeutics, identifying several drug classes inducing strong disruptions to the microbial ecosystem, providing a comprehensive view of how drugs influence gut microbiome function and ecology at the protein level.

A long-read metagenomics method empowers faecal microbiota transplantation studies by precisely tracking bacteria from donors to recipients, distinguishing co-existing strains and revealing genomic changes that may reflect adaptation in the new hosts.

Here, the authors report the effects of provitamin A supplementation, in the form of red palm olein (RPO)-enriched biscuits, on the gut microbiota of vitamin A deficient primary schoolchildren in rural Malaysia.

An approach combining BONCAT, stable isotope probing and metaproteomics showcases the hidden metabolic interconnectivity of microorganisms within an anaerobic digestion community.

The gut microbiota-derived metabolite indole-3-propionic acid (IPA) is found to enhance mitochondrial fatty acid and amino acid oxidation in CD4⁺ T cells. In mice, IPA-mediated metabolic reprogramming of CD4⁺ T cells exerts anti-inflammatory effects and protects against colitis.

Microbiota-derived metabolites shape intestinal health by modulating T cell metabolism. Li et al. show that indole-3-propionic acid (IPA) promotes mitochondrial respiration to suppress pro-inflammatory T cell differentiation, thereby alleviating inflammatory bowel disease in humans and mice.

Drought reshapes microbial communities around wheat roots. Synthetic microbial communities constructed from single-cell-sorted drought-tolerant bacteria provide a promising strategy to enhance crop resilience.

Architects and microbiologists are exploring whether making buildings hospitable to friendly microorganisms can improve human health.

In this study, Van Syoc et al. investigate the human gut mycobiome in the context of primate evolution.

Certain gut bacteria help to extend the reproductive lifespan of female mice, experiments show.