Pseudomonas aeruginosa is a functionally versatile bacterium, a leading opportunistic human pathogen and a model organism in microbiology. In this Review, Letizia, Diggle and Whiteley discuss P. aeruginosa’s quorum sensing, biofilm formation, virulence, epidemiology, resistance mechanisms and infection control strategies.

In this Review, Mondo and Grigoriev explore the central role of omics approaches to investigate the biology and evolution of fungi and understand phylogeny and how traits evolved over time within the fungal kingdom.

In this Review, Klasse et al. explore the biogenesis and structure of the HIV-1 envelope glycoprotein (Env) and examine its functional role in viral entry. They also discuss how neutralizing antibodies interact with Env, the evolution of broadly neutralizing antibodies (bnAbs) and strategies to elicit bnAbs through germline-targeting immunogen design.

This study shows that metabolic inactivity confers tolerance against polymyxin antibiotics and proposes a model for polymyxin-mediated killing of metabolically active bacterial cells.

This study reports the identification of cell-surface low-density lipoprotein receptor-related protein 8 (LRP8) as the crucial host factor that mediates tick-borne encephalitis virus entry and infection.

In this study, Van Syoc et al. investigate the human gut mycobiome in the context of primate evolution.

In this Journal Club, Liam Mark Rooney discusses a paper that revealed that microbial communities are capable of emergent, collective behaviour.

This study reports the identification of two prophage-encoded systems involved in anti-phage defence through Abi.

This Genome Watch article explores how metagenomics can be used to investigate viral diversity and track emerging zoonotic disease threats from wildlife.