Nature Reviews Microbiology Nature Reviews Microbiology takes a uniquely integrated approach to microbiology, bridging fundamental research on bacteria, archaea, viruses, fungi and protozoan parasites with its clinical, industrial and environmental applications. All Reviews, Perspectives and Progress articles are commissioned from leaders in the field and undergo rigorous peer review, which results in authoritative, timely articles. Articles are carefully edited and the figures redrawn by professional art editors, creating highly readable, visually attractive articles that are accessible to specialists and non-specialists alike. In addition, each issue contains Research Highlights, providing critical summaries of significant recent research papers as well as a monthly update on the latest advances in microbial genomics – in collaboration with the Wellcome Trust Sanger Institute. http://feeds.nature.com/nrmicro/rss/current Nature Publishing Group en © 2025 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Reviews Microbiology © 2025 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. [email protected]
  • Nature Reviews Microbiology https://www.nature.com/uploads/product/nrmicro/rss.gif http://feeds.nature.com/nrmicro/rss/current <![CDATA[Licence to knockdown — the phage gene silencer]]> https://www.nature.com/articles/s41579-025-01253-z <![CDATA[
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    Nature Reviews Microbiology, Published online: 22 October 2025; doi:10.1038/s41579-025-01253-z

    This Genome Watch explores how a new antisense oligomer-based approach enables functional genomics of genetically intractable bacteriophages, revealing essential genes and infection mechanisms without requiring genetic modification.]]> <![CDATA[Licence to knockdown — the phage gene silencer]]> Uri Neri doi:10.1038/s41579-025-01253-z Nature Reviews Microbiology, Published online: 2025-10-22; | doi:10.1038/s41579-025-01253-z 2025-10-22 Nature Reviews Microbiology 10.1038/s41579-025-01253-z https://www.nature.com/articles/s41579-025-01253-z <![CDATA[Bacterial cell envelope-targeting antibiotics]]> https://www.nature.com/articles/s41579-025-01247-x <![CDATA[

    Nature Reviews Microbiology, Published online: 13 October 2025; doi:10.1038/s41579-025-01247-x

    In this Review, Weingarth and colleagues discuss both recently discovered compounds and established envelope-targeting antibiotics, including compounds that target Gram-positive bacteria, more complex Gram-negative bacteria and mycobacterial pathogens, with a particular focus on their drug–target interactions.]]>     <![CDATA[Bacterial cell envelope-targeting antibiotics]]> Charalampos NtallisNathaniel I. MartinAndrew M. EdwardsMarkus Weingarth doi:10.1038/s41579-025-01247-x Nature Reviews Microbiology, Published online: 2025-10-13; | doi:10.1038/s41579-025-01247-x 2025-10-13 Nature Reviews Microbiology 10.1038/s41579-025-01247-x https://www.nature.com/articles/s41579-025-01247-x     <![CDATA[Energizing antibiotic killing]]> https://www.nature.com/articles/s41579-025-01252-0 <![CDATA[

    Nature Reviews Microbiology, Published online: 08 October 2025; doi:10.1038/s41579-025-01252-0

    This study shows that metabolic inactivity confers tolerance against polymyxin antibiotics and proposes a model for polymyxin-mediated killing of metabolically active bacterial cells.]]>     <![CDATA[Energizing antibiotic killing]]> Andrea Du Toit doi:10.1038/s41579-025-01252-0 Nature Reviews Microbiology, Published online: 2025-10-08; | doi:10.1038/s41579-025-01252-0 2025-10-08 Nature Reviews Microbiology 10.1038/s41579-025-01252-0 https://www.nature.com/articles/s41579-025-01252-0     <![CDATA[Viral emergence and pandemic preparedness in a One Health framework]]> https://www.nature.com/articles/s41579-025-01243-1 <![CDATA[

    Nature Reviews Microbiology, Published online: 03 October 2025; doi:10.1038/s41579-025-01243-1

    In this Review, Sikkema and Koopmans examine the drivers of viral emergence and how these insights could inform prevention strategies and the development of risk-targeted One Health early warning surveillance. They discuss tools for diagnostics, surveillance and virus characterization, and propose strengthening integrated One Health strategies for early warning, prevention and control of emerging infections at the human–animal interface.]]>     <![CDATA[Viral emergence and pandemic preparedness in a One Health framework]]> Reina S. SikkemaMarion Koopmans doi:10.1038/s41579-025-01243-1 Nature Reviews Microbiology, Published online: 2025-10-03; | doi:10.1038/s41579-025-01243-1 2025-10-03 Nature Reviews Microbiology 10.1038/s41579-025-01243-1 https://www.nature.com/articles/s41579-025-01243-1     <![CDATA[How tick-borne encephalitis virus gains entry]]> https://www.nature.com/articles/s41579-025-01249-9 <![CDATA[

    Nature Reviews Microbiology, Published online: 02 October 2025; doi:10.1038/s41579-025-01249-9

    This study reports the identification of cell-surface low-density lipoprotein receptor-related protein 8 (LRP8) as the crucial host factor that mediates tick-borne encephalitis virus entry and infection.]]>     <![CDATA[How tick-borne encephalitis virus gains entry]]> Andrea Du Toit doi:10.1038/s41579-025-01249-9 Nature Reviews Microbiology, Published online: 2025-10-02; | doi:10.1038/s41579-025-01249-9 2025-10-02 Nature Reviews Microbiology 10.1038/s41579-025-01249-9 https://www.nature.com/articles/s41579-025-01249-9     <![CDATA[The human gut mycobiome in the context of primate evolution]]> https://www.nature.com/articles/s41579-025-01250-2 <![CDATA[

    Nature Reviews Microbiology, Published online: 02 October 2025; doi:10.1038/s41579-025-01250-2

    In this study, Van Syoc et al. investigate the human gut mycobiome in the context of primate evolution.]]>     <![CDATA[The human gut mycobiome in the context of primate evolution]]> Shimona Starling doi:10.1038/s41579-025-01250-2 Nature Reviews Microbiology, Published online: 2025-10-02; | doi:10.1038/s41579-025-01250-2 2025-10-02 Nature Reviews Microbiology 10.1038/s41579-025-01250-2 https://www.nature.com/articles/s41579-025-01250-2     <![CDATA[<i>Clostridioides difficile</i> pathogenesis and control]]> https://www.nature.com/articles/s41579-025-01242-2 <![CDATA[

    Nature Reviews Microbiology, Published online: 02 October 2025; doi:10.1038/s41579-025-01242-2

    Clostridioides difficile infection is challenging to diagnose and treat and is associated with considerable mortality, morbidity and economic costs worldwide. In this Review, Chilton et al. discuss changes in global epidemiology, breakthroughs in pathogenesis and antibiotic resistance, the role of microbiota dysbiosis and the potential for microbiota-based therapeutics for Clostridioides difficile infection.]]>     <![CDATA[<i>Clostridioides difficile</i> pathogenesis and control]]> Caroline H. ChiltonVirginie VipreyCharmaine NormingtonInes B. MouraAnthony M. BuckleyJane FreemanKerrie DaviesMark H. Wilcox doi:10.1038/s41579-025-01242-2 Nature Reviews Microbiology, Published online: 2025-10-02; | doi:10.1038/s41579-025-01242-2 2025-10-02 Nature Reviews Microbiology 10.1038/s41579-025-01242-2 https://www.nature.com/articles/s41579-025-01242-2     <![CDATA[Making waves: how biofilms find their rhythm]]> https://www.nature.com/articles/s41579-025-01245-z <![CDATA[

    Nature Reviews Microbiology, Published online: 01 October 2025; doi:10.1038/s41579-025-01245-z

    In this Journal Club, Liam Mark Rooney discusses a paper that revealed that microbial communities are capable of emergent, collective behaviour.]]>     <![CDATA[Making waves: how biofilms find their rhythm]]> Liam Mark Rooney doi:10.1038/s41579-025-01245-z Nature Reviews Microbiology, Published online: 2025-10-01; | doi:10.1038/s41579-025-01245-z 2025-10-01 Nature Reviews Microbiology 10.1038/s41579-025-01245-z https://www.nature.com/articles/s41579-025-01245-z