Older adults can be affected by multiple chronic medical conditions, including liver disease. This Review provides a comprehensive overview of age-related pathophysiological changes in the liver and discusses interventions and treatment options for older patients.

In this Review, Pasricha and Kulkarni describe the role of dopaminergic signalling pathways in the central nervous system and periphery, and their role in gastrointestinal health and disease. In addition, they discuss emerging evidence and future directions.

In this Perspective article, Huwyler, Binz and colleagues discuss the future of long-term normothermic machine perfusion for livers and propose a staged assessment approach for ex situ perfused organs.

After the regulatory rejection of obeticholic acid, peroxisome proliferator-activated receptor (PPAR) agonists have emerged as the leading second-line candidates for primary biliary cholangitis, pending definitive approval. Of these, only bezafibrate — a low-cost, widely available generic — has demonstrated long-term efficacy, a fact largely disregarded.

Submucosal endoscopy creates a new space to implant bioelectronics in a ‘scarless’ way, establishing a reliable interface between device and tissue that remains stable for months in the gastrointestinal tract. Submucosal bioelectronics, combining diagnostic and therapeutic functions, hold great promise as powerful tools to advance both fundamental understanding and clinical management of gastrointestinal disease.