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Clonal haematopoiesis in cardiovascular disease

Prognostic role and novel therapeutic target

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    This Focus issue on atheroimmunology highlights the importance of innate and adaptive immune mechanisms to the pathogenesis of atherosclerosis.

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    This Collection of articles from across the Nature Reviews portfolio explores the transformative role of artificial intelligence in health care, from drug discovery and development, through to applications in the risk stratification, diagnosis, imaging, monitoring, prognostication, and pharmacological and surgical treatment of patients.

  • A diverse group of people

    This ongoing Series of articles highlights the importance of a more diverse, equitable and inclusive cardiovascular workforce in improving the quality of patient care and scientific research.

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  • New evidence from five randomized trials suggests that withholding β-blockers after myocardial infarction (MI) is safe for carefully selected, low-risk patients. However, even if β-blockers are not required to treat ventricular dysfunction, hypertension or arrhythmias, it might still be wiser to continue treatment during the vulnerable period immediately after MI and withdraw treatment several months later.

    • John G. F. Cleland
    Clinical Outlook
  • Women in cardiology have long faced barriers, but their leadership is redefining the field. By turning bias into opportunity and exclusion into inclusion, initiatives such as Women As One are opening doors, advancing equity and shaping a more innovative, representative future for cardiovascular care.

    • Roxana Mehran
    • Karoline Bowman
    • Liesl Zühlke
    Comment
  • In patients with residual inflammation after acute myocardial infarction, antibody-mediated antagonism of the oxidized LDL receptor LOX1 does not induce significant regression of noncalcified atherosclerotic plaque volume over the course of 9 months compared with placebo, according to the GOLDILOX-TIMI 69 trial.

    • Irene Fernández-Ruiz
    Research Highlight
  • Large-scale clinical trials presented at the ESC Congress 2025 support the use of high-dose vaccination for influenza to reduce hospitalization for cardiorespiratory disease in older adults and to improve outcomes in patients who have been hospitalized for acute heart failure.

    • Gregory B. Lim
    Research Highlight
  • In the dynamic landscape of academic medicine, there is an increased interest in refining the traditional mentoring paradigm to address the many unmet challenges associated with gender disparities within academia. We highlight the need to expand the focus of mentorship to include sponsorship and advocacy, and hope that this shift will foster holistic development in mentees.

    • Alessia Gimelli
    • Suvasini Lakshmanan
    Comment

Anticoagulants

Anticoagulant drugs are used to prevent and treat thrombotic disorders in millions of patients worldwide. This Milestone plots the history of anticoagulant drugs, starting with the discovery and clinical trials of heparin and warfarin.
Milestone

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    Sir Run Run Shaw Hospital Affiliated with Zhejiang University School of Medicine

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    The Faculty of Medicine of the University of Zurich invites applications for a Professorship and Chair of Pediatric Cardiac Surgery. The professors...

    Zurich, Canton of Zürich (CH)

    University of Zurich (UZH)

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    Provide clinical care for neonatology patients at 4 Level III/IV NICUs. Academic work (educ., investigation, admin./service, advocacy.

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    University of Utah

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    Columbia University Irving Medical Center, NY Postdoctoral Research Scientist The Wan Lab at Columbia University Medical Center is seeking a Postdo...

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    St Jude Children's Research Hospital

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