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Viewing protein evolution through the lens of complex systems theory may offer new insights into the principles driving biological adaptation. In this Comment we explore how characteristics such as sensitivity to initial conditions and self-organization are observed in protein evolution and discuss how machine learning can help model these dynamics to guide protein engineering.
Chemical biology approaches have enhanced metabolism research through the detection of key metabolites and altering enzymatic reactions. This themed issue features a collection of articles that explore emerging research areas in the continual interplay between chemical biology and metabolism.
