MARUbylation is a hybrid post-translational protein modification in which mono-ADP-ribosylation acts as a scaffold for sequential mono- and polyubiquitylation. Recent studies illuminate its substrates, molecular recognition, and emerging roles in DNA repair.
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Kliza, K.W., Gersch, M. ADPr gets a ubiquitin upgrade. Nat Chem Biol (2025). https://doi.org/10.1038/s41589-025-02027-7
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DOI: https://doi.org/10.1038/s41589-025-02027-7
