Hydrogen peroxide (H2O2) is a key signaling molecule involved in many processes that affect health and contribute to disease, but tracking its real-time dynamics inside living cells remains challenging. A new set of biosensors now enables accurate, multiparametric monitoring of H2O2 levels without interference from changes in pH or oxygen.
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References
Sies, H. & Jones, D. P. Nat. Rev. Mol. Cell Biol. 21, 363–383 (2020).
Brand, M. D. Crit. Rev. Biochem. Mol. Biol. 55, 592–661 (2020).
Lee, J. D. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-025-01891-7 (2025).
Potekhina, E. S. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-025-02036-6 (2025).
Ning, L. et al. Front. Cell. Dev. Biol. 10, 893468 (2022).
Kim, S. O. Cell 109, 383–396 (2002).
Gauthier, A. et al. Acc. Chem. Res. 55, 31253135 (2022).
Kumagai, A. et al. Cell 153, 1602–1611 (2013).
Eaglesfield, R. et al. Redox Biol. 80, 103502 (2025).
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Fransen, M., Lismont, C. Lighting up hydrogen peroxide. Nat Chem Biol (2025). https://doi.org/10.1038/s41589-025-02022-y
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DOI: https://doi.org/10.1038/s41589-025-02022-y
