ELOVL6 is an acyltransferase involved in the synthesis of saturated and monounsaturated fatty acids. New work finds that inhibition of ELOVL6 function results in mislocalization of oncogenic KRAS from the plasma membrane, which in turn abolishes KRAS-G12V oncogenesis.
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Zhou, Y., Hancock, J.F. Terraforming the KRAS lipid landscape. Nat Chem Biol (2025). https://doi.org/10.1038/s41589-025-01992-3
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DOI: https://doi.org/10.1038/s41589-025-01992-3
