Fig. 6: Selected examples of specific newly predicted function annotations spanning pathways and functions in the human gut microbiome.
From: Predicting functions of uncharacterized gene products from microbial communities
a–h, Examples of newly predicted high-confidence annotations ranged across housekeeping process (a), species-specific functions (b), common gut taxa (c,d) and less studied species with numerous novel proteins (e–h), demonstrating strong correlation between transcripts of uncharacterized protein families (that is, SU, RH and NH) and characterized families (that is, SC) for diverse BP terms in the HMP2. Each node represents a protein family that was assigned to the corresponding term from preserved annotations or by FUGAsseM’s prediction with the stringent threshold. Nodes are linked when the correlation coefficient of the transcripts exceeds the 90th percentile of all MTX-based correlations per species per term. The width of each edge represents the correlation coefficient. Edges are colored on the basis of the prediction importance of MTX-based coexpression in FUGAsseM’s integrated models, where coexpression importance < 0.1 represents a ‘weak’ contribution, importance > 0.5 represents a ‘strong’ contribution and other edges represent a ‘moderate’ contribution from coexpression.
