Extended Data Fig. 8: Domain architectures support FUGAsseM function predictions in Faecalibacterium prausnitzii and Bacteroides thetaiotaomicron.
From: Predicting functions of uncharacterized gene products from microbial communities
(a) Proteins predicted with viral life cycle (GO:0019058) showed similar domain architectures with the previously annotated proteins, clustering into two main phage clusters. (b) Similarly, proteins predicted with defend response to virus (GO:0051607) exhibited domain patterns characteristic of two distinct CRISPR systems. Proteins shown were also strongly coexpressed (Fig. 6c). (c) In B. thetaiotaomicron, proteins predicted with cellular carbohydrate catabolic process (GO:0044275) contained glycosyl hydrolase and outer membrane—key components of the starch utilization system for carbohydrate metabolism. Domain architectures of randomly selected 25 B. thetaiotaomicron’s proteins predicted with GO:0044275 (strongly coexpressed in Fig. 6e) are shown.
