Skip to main content
See More

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Animal biotechnology

Genome-edited farm animals from haploid stem cells

Nature Biotechnology (2025)Cite this article

Subjects

Spermatid-like haploid stem cells produce genome-edited farm animals in one generation.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Generation of genome-edited livestock from spermatid-like haESCs.

References

  1. Yang, L. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-025-02832-4 (2025).

  2. Leeb, M. & Wutz, A. Nature 479, 131–134 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Elling, U. et al. Cell Stem Cell 9, 563–574 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Yi, M., Hong, N. & Hong, Y. Science 326, 430–433 (2009).

    Article  CAS  PubMed  Google Scholar 

  5. Yang, H. et al. Cell 149, 605–617 (2012).

    Article  CAS  PubMed  Google Scholar 

  6. Wan, H. et al. Cell Res. 23, 1330–1333 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Elling, U. et al. Nature 550, 114–118 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Smith, A. Development 144, 365–373 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Antony, J., Oback, F., Chamley, L. W., Oback, B. & Laible, G. Mol. Cell. Biol. 33, 974–983 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Czernik, M., Iuso, D., Toschi, P., Khochbin, S. & Loi, P. Nat. Protoc. 11, 2170–2188 (2016).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Bioeconomy Science Institute, Nelson, New Zealand

    Björn Oback

Authors
  1. Björn Oback
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Björn Oback.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Oback, B. Genome-edited farm animals from haploid stem cells. Nat Biotechnol (2025). https://doi.org/10.1038/s41587-025-02769-8

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41587-025-02769-8

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research